protected override void Context()
{
_context = A.Fake <IExecutionContext>();
var expressionProfile = DomainHelperForSpecs.CreateExpressionProfile <IndividualEnzyme>();
(_molecule, _) = expressionProfile;
_protein = _molecule.DowncastTo <IndividualProtein>();
_result = new QueryExpressionResults(_expressionResults);
_simulationSubject = A.Fake <ISimulationSubject>();
sut = new EditIndividualMoleculeExpressionInSimulationSubjectFromQueryCommand(_molecule, _result, _simulationSubject);
A.CallTo(() => _simulationSubject.AllExpressionParametersFor(_molecule)).Returns(_allExpressionParameters);
}
protected override void Context()
{
_parameter = DomainHelperForSpecs.NormalDistributedParameter();
_oldPercentile = _parameter.Percentile;
_parameter.Id = "tralala";
_executionContext = A.Fake <IExecutionContext>();
A.CallTo(() => _executionContext.Get <IParameter>(_parameter.Id)).Returns(_parameter);
A.CallTo(() => _executionContext.BuildingBlockContaining(_parameter)).Returns(A.Fake <IPKSimBuildingBlock>());
_percentile = 0.4;
_parameter.IsFixedValue = true;
sut = new SetParameterPercentileCommand(_parameter, _percentile);
}
protected override void Context()
{
base.Context();
var para1 = DomainHelperForSpecs.ConstantParameterWithValue(1).WithName("para1").WithDimension(A.Fake <IDimension>());
var para2 = DomainHelperForSpecs.ConstantParameterWithValue(2).WithName("para1").WithDimension(A.Fake <IDimension>());
A.CallTo(() => _executionContext.BuildingBlockContaining(para1)).Returns(A.Fake <IPKSimBuildingBlock>());
A.CallTo(() => _executionContext.BuildingBlockContaining(para2)).Returns(A.Fake <IPKSimBuildingBlock>());
_parameters = new List <IParameter> {
para1, para2
};
A.CallTo(() => _executionContext.Resolve <IParameterTask>()).Returns(sut);
}
private void addPkAParameters(Model.Compound compound, int index, double pkA, CompoundType compoundType)
{
var pkaParameter = DomainHelperForSpecs.ConstantParameterWithValue(pkA).WithName(CoreConstants.Parameters.ParameterPKa(index));
pkaParameter.ValueOrigin.UpdateFrom(_pkaValueOrigin);
A.CallTo(() => _valueOriginMapper.MapToSnapshot(pkaParameter.ValueOrigin)).Returns(_snapshotValueOrigin);
compound.Add(pkaParameter);
var compoundTypeParameter = DomainHelperForSpecs.ConstantParameterWithValue((int)compoundType).WithName(Constants.Parameters.ParameterCompoundType(index));
compoundTypeParameter.ValueOrigin.UpdateFrom(_pkaValueOrigin);
A.CallTo(() => _valueOriginMapper.MapToSnapshot(compoundTypeParameter.ValueOrigin)).Returns(_snapshotValueOrigin);
compound.Add(compoundTypeParameter);
}
protected override void Context()
{
_molecule = new IndividualEnzyme
{
DomainHelperForSpecs.ConstantParameterWithValue(0).WithName(CoreConstants.Parameters.ONTOGENY_FACTOR),
DomainHelperForSpecs.ConstantParameterWithValue(0).WithName(CoreConstants.Parameters.ONTOGENY_FACTOR_GI)
};
_ontogeny = new DatabaseOntogeny();
_ontogenyRepository = A.Fake <IOntogenyRepository>();
_entityPathResolver = new EntityPathResolverForSpecs();
sut = new MoleculeOntogenyVariabilityUpdater(_ontogenyRepository, _entityPathResolver);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_curve);
_anotherRepository = DomainHelperForSpecs.ObservedData();
_y2Column = _anotherRepository.AllButBaseGrid().First();
_y2Column.QuantityInfo.Path = new[] { "D", "E", "F" };
_context = new SimulationAnalysisContext(new[] { _dataRepository, _anotherRepository, }, new SnapshotContext());
_snapshot.CurveOptions.Color = Color.Aqua;
_snapshot.X = _y2Column.PathAsString;
}
protected override async Task Context()
{
await base.Context();
_individualParameter = DomainHelperForSpecs.ConstantParameterWithValue(1).WithName("IndParam");
_individualParameterTemplate = DomainHelperForSpecs.ConstantParameterWithValue(1).WithName("IndParam");
_individualParameter.BuildingBlockType = PKSimBuildingBlockType.Individual;
_individualParameter.Origin.BuilingBlockId = _individual.Id;
_individualParameter.Origin.ParameterId = "IndParamTemplateId";
_individualParameterChanged = DomainHelperForSpecs.ConstantParameterWithValue(2).WithName("IndParamChanged");
_individualParameterChangedTemplate = DomainHelperForSpecs.ConstantParameterWithValue(10000).WithName("IndParamChanged");
_individualParameterChanged.BuildingBlockType = PKSimBuildingBlockType.Individual;
_individualParameterChanged.Origin.BuilingBlockId = _individual.Id;
_individualParameterChanged.Origin.ParameterId = "IndParamChangedTemplateId";
_simulationParameter = DomainHelperForSpecs.ConstantParameterWithValue(2).WithName("SimParam");
_simulationParameter.BuildingBlockType = PKSimBuildingBlockType.Simulation;
_protocolParameter = DomainHelperForSpecs.ConstantParameterWithValue(2).WithName("ProtocolParam");
_protocolParameter.BuildingBlockType = PKSimBuildingBlockType.Protocol;
_protocolParameter.Origin.BuilingBlockId = _protocol.Id;
_protocolParameter.Origin.ParameterId = "ProtocolParamTemplateId";
_rootContainer.Add(_individualParameter);
_rootContainer.Add(_individualParameterChanged);
_rootContainer.Add(_simulationParameter);
_rootContainer.Add(_protocolParameter);
_localizedParameters = new[] { _individualChangedParameterSnapshot, _simulationParameterSnapshot, _protocolParameterSnapshot };
A.CallTo(() => _parameterMapper.LocalizedParametersFrom(A <IEnumerable <IParameter> > .That.Matches(x => x.ContainsAll(new[] { _individualParameterChanged, _simulationParameter, _protocolParameter }))))
.Returns(_localizedParameters);
A.CallTo(() => _executionContext.Get <IParameter>(_individualParameterChanged.Origin.ParameterId)).Returns(_individualParameterChangedTemplate);
A.CallTo(() => _executionContext.Get <IParameter>(_individualParameter.Origin.ParameterId)).Returns(_individualParameterTemplate);
_protocolTemplateBuildingBlock = new SimpleProtocol {
Id = "ProtTemplateId"
};
_project.AddBuildingBlock(_protocolTemplateBuildingBlock);
var allIndividualTemplateParameters = new PathCacheForSpecs <IParameter>();
A.CallTo(() => _containerTask.CacheAllChildren <IParameter>(_individual)).Returns(allIndividualTemplateParameters);
allIndividualTemplateParameters.Add(_individualParameterTemplate.Name, _individualParameterTemplate);
allIndividualTemplateParameters.Add(_individualParameterChangedTemplate.Name, _individualParameterChangedTemplate);
A.CallTo(() => _entityPathResolver.PathFor(_individualParameterTemplate)).Returns(_individualParameterTemplate.Name);
A.CallTo(() => _entityPathResolver.PathFor(_individualParameterChangedTemplate)).Returns(_individualParameterChangedTemplate.Name);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_dataRepository);
_baseGrid = new BaseGrid("baseGrid", DomainHelperForSpecs.TimeDimensionForSpecs());
_mappedDataColumn = new DataColumn("DataColumn", DomainHelperForSpecs.ConcentrationDimensionForSpecs(), _baseGrid);
_mappedRelatedColumn = new DataColumn("RelatedColumn", DomainHelperForSpecs.ConcentrationDimensionForSpecs(), _baseGrid);
_mappedDataColumn.AddRelatedColumn(_mappedRelatedColumn);
A.CallTo(() => _dataColumnMapper.MapToModel(_snapshot.BaseGrid, A <SnapshotContextWithDataRepository> ._)).Returns(_baseGrid);
A.CallTo(() => _dataColumnMapper.MapToModel(_snapshot.Columns.First(), A <SnapshotContextWithDataRepository> ._)).Returns(_mappedDataColumn);
}
protected override void Context()
{
_formulaTypeMapper = A.Fake <IParameterToFomulaTypeMapper>();
_executionContext = A.Fake <IExecutionContext>();
_entityPathResolver = A.Fake <IEntityPathResolver>();
_favoriteTask = A.Fake <IFavoriteTask>();
_parameterTask = new ParameterTask(_entityPathResolver, _executionContext, _favoriteTask);
sut = new ParameterUpdater(_formulaTypeMapper, _parameterTask);
_sourceParameter = DomainHelperForSpecs.ConstantParameterWithValue(0);
_sourceParameter.BuildingBlockType = PKSimBuildingBlockType.Individual;
_targetParameter = DomainHelperForSpecs.ConstantParameterWithValue(1);
_targetParameter.BuildingBlockType = PKSimBuildingBlockType.Individual;
A.CallTo(() => _executionContext.BuildingBlockContaining(_targetParameter)).Returns(A.Fake <IPKSimBuildingBlock>());
}
protected override Task Context()
{
_descriptorConditionMapper = A.Fake <DescriptorConditionMapper>();
_explicitFormulaMapper = A.Fake <ExplicitFormulaMapper>();
_moleculeListMapper = A.Fake <MoleculeListMapper>();
_objectBaseFactory = A.Fake <IObjectBaseFactory>();
_dimensionRepository = A.Fake <IDimensionRepository>();
_logger = A.Fake <ILogger>();
_dimension = DomainHelperForSpecs.TimeDimensionForSpecs();
_amountObserver = new AmountObserverBuilder {
Dimension = _dimension
};
_containerObserver = new ContainerObserverBuilder {
Dimension = _dimension
};
_formula = new OSPSuite.Core.Domain.Formulas.ExplicitFormula("1+2");
_amountObserver.Formula = _formula;
_containerObserver.Formula = _formula;
_moleculeListSnapshot = new MoleculeList();
_snapshotFormula = new ExplicitFormula();
_newMoleculeList = new OSPSuite.Core.Domain.Builder.MoleculeList();
_newMoleculeList.AddMoleculeNameToExclude("A");
_newMoleculeList.AddMoleculeName("B");
_newMoleculeList.ForAll = false;
_newFormula = new OSPSuite.Core.Domain.Formulas.ExplicitFormula("New");
sut = new ObserverMapper(
_descriptorConditionMapper,
_explicitFormulaMapper,
_moleculeListMapper,
_objectBaseFactory,
_dimensionRepository,
_logger);
A.CallTo(() => _explicitFormulaMapper.MapToSnapshot(_formula)).Returns(_snapshotFormula);
A.CallTo(() => _explicitFormulaMapper.MapToModel(_snapshotFormula)).Returns(_newFormula);
A.CallTo(() => _moleculeListMapper.MapToSnapshot(_amountObserver.MoleculeList)).Returns(_moleculeListSnapshot);
A.CallTo(() => _moleculeListMapper.MapToSnapshot(_containerObserver.MoleculeList)).Returns(_moleculeListSnapshot);
A.CallTo(() => _moleculeListMapper.MapToModel(_moleculeListSnapshot)).Returns(_newMoleculeList);
A.CallTo(() => _dimensionRepository.DimensionByName(_dimension.Name)).Returns(_dimension);
A.CallTo(() => _objectBaseFactory.Create <AmountObserverBuilder>()).Returns(new AmountObserverBuilder());
A.CallTo(() => _objectBaseFactory.Create <ContainerObserverBuilder>()).Returns(new ContainerObserverBuilder());
return(_completed);
}
protected override void Context()
{
base.Context();
var container = new Container();
_parameter = DomainHelperForSpecs.ConstantParameterWithValue(_oldValue)
.WithId("Id")
.WithDimension(_dimension)
.WithName("P1");
_parameter.BuildingBlockType = PKSimBuildingBlockType.Simulation;
container.Add(_parameter);
_parameter.DisplayUnit = _unit;
sut = new SetParameterValueCommand(_parameter, _valueToSet);
}
protected override void Context()
{
base.Context();
_para1 = DomainHelperForSpecs.ConstantParameterWithValue(_value1).WithName(CoreConstants.Parameter.EHC_ENABLED).WithDimension(A.Fake <IDimension>());
_para1.Editable = true;
_para2 = DomainHelperForSpecs.ConstantParameterWithValue(_value2).WithName("para2").WithDimension(A.Fake <IDimension>());
_para2.Editable = true;
_para3 = DomainHelperForSpecs.ConstantParameterWithValue(_value3).WithName(CoreConstants.Parameter.PARTICLE_DISPERSE_SYSTEM).WithDimension(A.Fake <IDimension>());
_para3.Editable = true;
A.CallTo(_executionContext).WithReturnType <IPKSimBuildingBlock>().Returns(A.Fake <IPKSimBuildingBlock>());
_parameterToScale.Add(_para1);
_parameterToScale.Add(_para2);
_parameterToScale.Add(_para3);
}
protected override void Context()
{
base.Context();
_para1 = DomainHelperForSpecs.ConstantParameterWithValue(_value1).WithName("para1").WithDimension(A.Fake <IDimension>());
_para1.Editable = true;
_para2 = DomainHelperForSpecs.ConstantParameterWithValue(_value2).WithName("para2").WithDimension(A.Fake <IDimension>());
_para2.Editable = true;
_para3 = DomainHelperForSpecs.ConstantParameterWithValue(_value3).WithName("para3").WithDimension(A.Fake <IDimension>());
_para3.Editable = false;
A.CallTo(() => _executionContext.BuildingBlockContaining(_para1)).Returns(A.Fake <IPKSimBuildingBlock>());
A.CallTo(() => _executionContext.BuildingBlockContaining(_para2)).Returns(A.Fake <IPKSimBuildingBlock>());
_parameterToScale.Add(_para1);
_parameterToScale.Add(_para2);
_parameterToScale.Add(_para3);
}
protected override void Context()
{
base.Context();
_protein = A.Fake <IndividualProtein>();
_protein.QueryConfiguration = "toto";
_exp1 = new MoleculeExpressionContainer().WithName("exp1");
_exp2 = new MoleculeExpressionContainer().WithName("exp2");
_expInfo1 = A.Fake <ExpressionContainerInfo>();
_expInfo2 = A.Fake <ExpressionContainerInfo>();
A.CallTo(() => _protein.AllExpressionsContainers()).Returns(new[] { _exp1, _exp2 });
_proteinContent = 10;
A.CallTo(() => _protein.ReferenceConcentration).Returns(DomainHelperForSpecs.ConstantParameterWithValue(_proteinContent));
A.CallTo(() => _expressionContainerMapper.MapFrom(_exp1)).Returns(_expInfo1);
A.CallTo(() => _expressionContainerMapper.MapFrom(_exp2)).Returns(_expInfo2);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_advancedParameter);
_parameter = DomainHelperForSpecs.ConstantParameterWithValue(5);
_mappedAdvancedParameter = new AdvancedParameter {
DistributedParameter = DomainHelperForSpecs.NormalDistributedParameter()
};
_pathCache = new PathCacheForSpecs <IParameter> {
{ _advancedParameter.ParameterPath, _parameter }
};
A.CallTo(() => _advancedParameterFactory.Create(_parameter, DistributionTypes.ById(_snapshot.DistributionType))).Returns(_mappedAdvancedParameter);
}
protected override void Context()
{
base.Context();
_para1 = DomainHelperForSpecs.ConstantParameterWithValue(_value1).WithName(Constants.Parameters.EHC_ENABLED);
_para1.Editable = true;
_para2 = DomainHelperForSpecs.ConstantParameterWithValue(_value2).WithName("para2");
_para2.Editable = true;
_para3 = DomainHelperForSpecs.ConstantParameterWithValue(_value3).WithName(Constants.Parameters.PARTICLE_DISPERSE_SYSTEM);
_para3.Editable = true;
_parameterToScale.Add(_para1);
_parameterToScale.Add(_para2);
_parameterToScale.Add(_para3);
_setCommand = A.Fake <IPKSimCommand>();
A.CallTo(() => _parameterTask.SetParameterValue(_para2, _value2 * _factor, true)).Returns(_setCommand);
}
protected override void Context()
{
base.Context();
_ddiRatioSimulation = new IndividualSimulation();
//Simulate calculated results by setting the DataRepository
_ddiRatioSimulation.DataRepository = _simulation.DataRepository;
_pkAnalysis = new PKAnalysis();
_pkAnalysis.Add(DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(Constants.PKParameters.C_max));
_pkAnalysis.Add(DomainHelperForSpecs.ConstantParameterWithValue(2).WithName(Constants.PKParameters.AUC_inf));
A.CallTo(() => _globalPKAnalysisRunner.RunForDDIRatio(_simulation)).Returns(_ddiRatioSimulation);
A.CallTo(() => _pkAnalysisTask.CalculateFor(_ddiRatioSimulation, _peripheralVenousBloodPlasma)).Returns(new IndividualPKAnalysis(_peripheralVenousBloodPlasma, _pkAnalysis));
}
protected override void Context()
{
base.Context();
_parameter = A.Fake <IParameter>().WithName(Constants.Parameters.MOL_WEIGHT);
A.CallTo(() => _buildingBockRetriever.BuildingBlockContaining(_parameter)).Returns(null);
_observedData = DomainHelperForSpecs.ObservedData();
_observedData.ExtendedProperties.Add(new ExtendedProperty <string> {
Name = Constants.ObservedData.MOLECULE, Value = "C"
});
_observedData.AllButBaseGrid().Each(c => c.DataInfo.MolWeight = 100);
_observedDataList.AddRange(new[] { _observedData });
}
protected override Task Context()
{
_parameterMapper = A.Fake <ParameterMapper>();
_expressionProfileMapper = A.Fake <ExpressionProfileMapper>();
_dimensionRepository = A.Fake <IDimensionRepository>();
_individualFactory = A.Fake <IIndividualFactory>();
_originDataMapper = A.Fake <OriginDataMapper>();
_moleculeExpressionTask = A.Fake <IMoleculeExpressionTask <ModelIndividual> >();
sut = new IndividualMapper(_parameterMapper, _expressionProfileMapper, _originDataMapper, _individualFactory, _moleculeExpressionTask);
_individual = DomainHelperForSpecs.CreateIndividual();
_individual.Name = "Ind";
_individual.Description = "Model Description";
var kidney = _individual.EntityAt <IContainer>(Constants.ORGANISM, CoreConstants.Organ.KIDNEY);
_parameterLiver = _individual.EntityAt <IParameter>(Constants.ORGANISM, CoreConstants.Organ.LIVER, "PLiver");
_parameterKidney = _individual.EntityAt <IParameter>(Constants.ORGANISM, CoreConstants.Organ.KIDNEY, "PKidney");
_parameterKidneyRelExp = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.REL_EXP);
_parameterKidneyRelExp.DefaultValue = 10;
kidney.Add(_parameterKidneyRelExp);
_parameterLiver.ValueDiffersFromDefault().ShouldBeFalse();
_parameterKidney.ValueDiffersFromDefault().ShouldBeFalse();
_parameterKidney.Value = 40;
_parameterKidney.ValueDiffersFromDefault().ShouldBeTrue();
_parameterKidneyRelExp.Value = 50;
_parameterKidneyRelExp.ValueDiffersFromDefault().ShouldBeTrue();
_expressionProfile1 = DomainHelperForSpecs.CreateExpressionProfile <IndividualEnzyme>(moleculeName: "Enz");
_expressionProfile2 = DomainHelperForSpecs.CreateExpressionProfile <IndividualTransporter>(moleculeName: "Trans");
_individual.AddExpressionProfile(_expressionProfile1);
_individual.AddExpressionProfile(_expressionProfile2);
_originDataSnapshot = new OriginData();
A.CallTo(() => _originDataMapper.MapToSnapshot(_individual.OriginData)).Returns(_originDataSnapshot);
_localizedParameterKidney = new LocalizedParameter {
Path = "Organism|Kidney|PKidney"
};
A.CallTo(() => _parameterMapper.LocalizedParametersFrom(A <IEnumerable <IParameter> > ._))
.Invokes(x => _mappedParameters = x.GetArgument <IEnumerable <IParameter> >(0).ToList())
.Returns(new[] { _localizedParameterKidney });
return(_completed);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_individualSimulation, _project);
var individualSimulation = new IndividualSimulation
{
Properties = _simulationProperties,
SimulationSettings = _settings,
Model = _model
};
individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndTemplateId", PKSimBuildingBlockType.Individual)
{
Name = _individual.Name,
BuildingBlock = _individual
});
_modelProperties = new ModelProperties();
A.CallTo(() => _modelPropertiesTask.DefaultFor(_individual.OriginData, _snapshot.Model)).Returns(_modelProperties);
A.CallTo(() => _simulationFactory.CreateFrom(_individual, A <IReadOnlyList <Compound> > ._, _modelProperties, null)).Returns(individualSimulation);
_outputSelection = new OSPSuite.Core.Domain.OutputSelections();
_outputSelection.AddOutput(new QuantitySelection("PATH", QuantityType.BaseGrid));
A.CallTo(() => _outputSelectionMapper.MapToModel(_snapshot.OutputSelections, individualSimulation)).Returns(_outputSelection);
_solver = new SolverSettings();
A.CallTo(() => _solverSettingsMapper.MapToModel(_snapshot.Solver)).Returns(_solver);
_outputSchema = new OutputSchema();
A.CallTo(() => _outputSchemaMapper.MapToModel(_snapshot.OutputSchema)).Returns(_outputSchema);
A.CallTo(() => _curveChartMapper.MapToModel(_snapshotSimulationTimeProfile, A <SimulationAnalysisContext> ._))
.Invokes(x => _context = x.GetArgument <SimulationAnalysisContext>(1))
.Returns(_simulationTimeProfile);
//ensure that run will be performed
_snapshot.HasResults = true;
_calculatedDataRepository = DomainHelperForSpecs.ObservedData("Calculated");
A.CallTo(() => _simulationRunner.RunSimulation(individualSimulation, A <SimulationRunOptions> ._))
.Invokes(x => { individualSimulation.DataRepository = _calculatedDataRepository; });
A.CallTo(() => _eventMappingMapper.MapToModel(_eventSelection, _project)).Returns(_eventMapping);
A.CallTo(() => _observerSetMappingMapper.MapToModel(_observerSetSelection, _project)).Returns(_observerSetMapping);
}
protected override void Context()
{
_executionContext = A.Fake <IExecutionContext>();
_favoriteTask = A.Fake <IFavoriteTask>();
_project = A.Fake <IProject>();
sut = new ParameterTask(new EntityPathResolver(new ObjectPathFactoryForSpecs()), _executionContext, _favoriteTask);
var dimensionFactory = new DimensionFactory();
_volumeDimension = dimensionFactory.AddDimension(new BaseDimensionRepresentation {
LengthExponent = 3
}, "Volume", "L");
_volumeDimension.AddUnit("mL", 1e-3, 0);
_parameter = DomainHelperForSpecs.ConstantParameterWithValue(10);
_parameter.Dimension = _volumeDimension;
A.CallTo(() => _executionContext.BuildingBlockContaining(_parameter)).Returns(A.Fake <IPKSimBuildingBlock>());
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_alternativeWithSpecies);
var newAlternativeWithSpecies = new ParameterAlternativeWithSpecies();
A.CallTo(() => _parameterAlternativeFactory.CreateAlternativeFor(_parameterGroup)).Returns(newAlternativeWithSpecies);
_snapshotParameter = new Parameter {
Name = "P1"
};
_alternativeParameter = DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(_snapshotParameter.Name);
newAlternativeWithSpecies.Add(_alternativeParameter);
_snapshot.Parameters = new[] { _snapshotParameter };
}
protected override void Context()
{
_simulation1 = A.Fake <Simulation>();
_lazyLoadTask = A.Fake <ILazyLoadTask>();
_rootContainer = new Container();
_applications = new EventGroup {
Name = Constants.APPLICATIONS, ContainerType = ContainerType.EventGroup
};
_applications2 = new EventGroup {
Name = "APPLICATIONS_2", ContainerType = ContainerType.EventGroup
};
_simulation1.Model.Root = _rootContainer;
_rootContainer.Add(_applications);
A.CallTo(() => _simulation1.BodyWeight).Returns(DomainHelperForSpecs.ConstantParameterWithValue(50));
sut = new PKCalculationOptionsFactory(_lazyLoadTask);
}
protected override void Context()
{
base.Context();
_individual = A.Fake<Individual>();
var originData = new OriginData();
originData.Population = new SpeciesPopulation();
A.CallTo(() => _individual.OriginData).Returns(originData);
var organism = new Organism();
var ga = DomainHelperForSpecs.ConstantParameterWithValue(5).WithName(Constants.Parameters.GESTATIONAL_AGE);
ga.Info.MinValue = 24;
ga.Info.MaxValue = 25;
organism.Add(ga);
organism.Add(DomainHelperForSpecs.ConstantParameterWithValue(5).WithName(CoreConstants.Parameters.MEAN_WEIGHT));
A.CallTo(() => _individual.IsPreterm).Returns(true);
A.CallTo(() => _individual.Organism).Returns(organism);
}
protected override void Context()
{
base.Context();
_originalSimulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_clonedSimulation = A.Fake <IndividualSimulation>();
A.CallTo(() => _cloner.Clone(_originalSimulation)).Returns(_clonedSimulation);
_pkSimulation = A.Fake <IndividualSimulation>().WithId("Clone");
var interactionContainer = new Container();
_parameter = DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(CoreConstants.Parameters.KI);
interactionContainer.Add(_parameter);
A.CallTo(() => _interactionTask.AllInteractionContainers(_pkSimulation)).Returns(new[] { interactionContainer });
A.CallTo(() => _objectBaseFactory.Create <IndividualSimulation>()).Returns(_pkSimulation);
}
protected override void Context()
{
base.Context();
var timeDimension = DomainHelperForSpecs.TimeDimensionForSpecs();
var concDimension = DomainHelperForSpecs.ConcentrationDimensionForSpecs();
_xAxis = new AxisData(timeDimension, timeDimension.DefaultUnit, Scalings.Linear)
{
Caption = "X"
};
_yAxis = new AxisData(concDimension, concDimension.DefaultUnit, Scalings.Linear)
{
Caption = "Y"
};
_chartData = new ChartData <TimeProfileXValue, TimeProfileYValue>(_xAxis, null, null, null);
var pane1 = new PaneData <TimeProfileXValue, TimeProfileYValue>(_yAxis)
{
Caption = "Male"
};
var pane2 = new PaneData <TimeProfileXValue, TimeProfileYValue>(_yAxis)
{
Caption = "Female"
};
_chartData.AddPane(pane1);
_chartData.AddPane(pane2);
var curve1 = new CurveData <TimeProfileXValue, TimeProfileYValue> {
Caption = "Liver"
};
curve1.Add(new TimeProfileXValue(1), new TimeProfileYValue {
Y = 10
});
curve1.Add(new TimeProfileXValue(2), new TimeProfileYValue {
LowerValue = 20, UpperValue = 30
});
pane1.AddCurve(curve1);
var curve2 = new CurveData <TimeProfileXValue, TimeProfileYValue> {
Caption = "Kidney"
};
curve2.Add(new TimeProfileXValue(3), new TimeProfileYValue {
Y = 40
});
pane2.AddCurve(curve2);
}
public T Clone <T>(T objectToClone) where T : class, IUpdatable
{
var schemaItem = objectToClone as ISchemaItem;
if (schemaItem == null)
{
return(default(T));
}
var cloneSchemaItem = new SchemaItem().WithName(Guid.NewGuid().ToString());
cloneSchemaItem.FormulationKey = schemaItem.FormulationKey;
cloneSchemaItem.ApplicationType = schemaItem.ApplicationType;
cloneSchemaItem.Add(DomainHelperForSpecs.ConstantParameterWithValue(schemaItem.Dose.Value).WithName(CoreConstants.Parameter.INPUT_DOSE));
cloneSchemaItem.Add(DomainHelperForSpecs.ConstantParameterWithValue(schemaItem.StartTime.Value).WithName(Constants.Parameters.START_TIME));
return(cloneSchemaItem.DowncastTo <T>());
}
protected override void Context()
{
_createIndvidualAlgorithm = A.Fake <ICreateIndividualAlgorithm>();
_entityBaseFactory = A.Fake <IObjectBaseFactory>();
_individualModelTask = A.Fake <IIndividualModelTask>();
_speciesRepository = A.Fake <ISpeciesRepository>();
_entityValidator = A.Fake <IEntityValidator>();
_reportGenerator = A.Fake <IReportGenerator>();
_moleculeOntogenyVariabilityUpdater = A.Fake <IMoleculeOntogenyVariabilityUpdater>();
sut = new IndividualFactory(_individualModelTask, _entityBaseFactory, _createIndvidualAlgorithm, _speciesRepository, _entityValidator, _reportGenerator, _moleculeOntogenyVariabilityUpdater);
_age = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.AGE);
_gestationalAge = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.GESTATIONAL_AGE);
_height = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.HEIGHT);
_weight = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.WEIGHT);
_bmi = DomainHelperForSpecs.ConstantParameterWithValue().WithName(CoreConstants.Parameters.BMI);
}
protected override void Context()
{
base.Context();
_parameter1 = DomainHelperForSpecs.ConstantParameterWithValue(1);
_parameter2 = DomainHelperForSpecs.ConstantParameterWithValue(2);
_parameter3 = DomainHelperForSpecs.ConstantParameterWithValue(3);
_parameterCache = A.Fake <PathCache <IParameter> >();
A.CallTo(() => _parameterCache["PATH1"]).Returns(_parameter1);
A.CallTo(() => _parameterCache["PATH2"]).Returns(_parameter2);
A.CallTo(() => _parameterCache["PATH3"]).Returns(_parameter3);
sut.SetValues("PATH1", new double[] { 1, 2, 3 });
sut.SetValues("PATH2", new double[] { 4, 5, 6 });
_cacheToMerge = new ParameterValuesCache();
_cacheToMerge.SetValues("PATH1", new double[] { 7, 8 });
_cacheToMerge.SetValues("PATH3", new double[] { 9, 10 });
}
protected override void Context()
{
_parameters = new List <IParameter>();
_parameter1 = DomainHelperForSpecs.ConstantParameterWithValue(10);
_parameter2 = DomainHelperForSpecs.ConstantParameterWithValue(10);
_valueOrigin = new ValueOrigin
{
Method = ValueOriginDeterminationMethods.Assumption,
Source = ValueOriginSources.Other,
Description = "Hello"
};
_context = A.Fake <IExecutionContext>();
sut = new UpdateParametersValueOriginCommand(_parameters, _valueOrigin);
}
