protected override void Context() { base.Context(); _populationCharacteristics = new PopulationCharacteristics { Species = CoreConstants.Species.HUMAN, Population = CoreConstants.Population.ICRP, Age = new ParameterRange { Min = 0, Max = 80, Unit = "year(s)", }, Weight = new ParameterRange { Min = 70, Unit = "kg", }, NumberOfIndividuals = 10, ProportionOfFemales = 70, Seed = 2 }; _populationCharacteristics.AddMoleculeOntogeny(new MoleculeOntogeny { Molecule = "CYP3A4", Ontogeny = "CYP3A4" }); _populationCharacteristics.AddMoleculeOntogeny(new MoleculeOntogeny { Molecule = "CYP2D6", Ontogeny = "CYP2D6" }); }
protected override void Context() { base.Context(); _populationCharacteristics = new PopulationCharacteristics { Species = CoreConstants.Species.HUMAN, Population = CoreConstants.Population.PRETERM, Age = new ParameterRange { Min = 0, Max = 80, Unit = "year(s)", }, Weight = new ParameterRange { Min = 70, Unit = "kg", }, GestationalAge = new ParameterRange { Min = 30, Max = 35, Unit = "week(s)", }, NumberOfIndividuals = 10, ProportionOfFemales = 70 }; }
public CreatePopulationResults CreatePopulation(PopulationCharacteristics populationCharacteristics) { var populationSettings = _populationSettingsMapper.MapToModel(populationCharacteristics, new SnapshotContext()).Result; validate(populationSettings); var population = _randomPopulationFactory.CreateFor(populationSettings, new CancellationToken(), seed: populationCharacteristics.Seed).Result; foreach (var moleculeOntogeny in populationCharacteristics.MoleculeOntogenies) { var allOntogeniesForSpecies = _ontogenyRepository.AllFor(populationCharacteristics.Individual.OriginData.Species); if (!allOntogeniesForSpecies.Any()) { continue; } var ontogeny = allOntogeniesForSpecies.FindByName(moleculeOntogeny.Ontogeny); if (ontogeny == null) { continue; } var molecule = _individualEnzymeFactory.CreateEmpty().WithName(moleculeOntogeny.Molecule); molecule.Ontogeny = ontogeny; population.AddMolecule(molecule); } _ontogenyVariabilityUpdater.UpdateAllOntogenies(population); return(new CreatePopulationResults(population.IndividualValuesCache, population.Seed)); }
protected override void Context() { base.Context(); _populationCharacteristics = new PopulationCharacteristics { Species = CoreConstants.Species.HUMAN, Population = CoreConstants.Population.ICRP, Age = new ParameterRange { Min = 20, Max = 15, Unit = "year(s)", }, NumberOfIndividuals = 10, ProportionOfFemales = 70 }; }