protected override void Context()
{
base.Context();
_populationCharacteristics = new PopulationCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.ICRP,
Age = new ParameterRange
{
Min = 0,
Max = 80,
Unit = "year(s)",
},
Weight = new ParameterRange
{
Min = 70,
Unit = "kg",
},
NumberOfIndividuals = 10,
ProportionOfFemales = 70,
Seed = 2
};
_populationCharacteristics.AddMoleculeOntogeny(new MoleculeOntogeny {
Molecule = "CYP3A4", Ontogeny = "CYP3A4"
});
_populationCharacteristics.AddMoleculeOntogeny(new MoleculeOntogeny {
Molecule = "CYP2D6", Ontogeny = "CYP2D6"
});
}
protected override void Context()
{
base.Context();
_populationCharacteristics = new PopulationCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.PRETERM,
Age = new ParameterRange
{
Min = 0,
Max = 80,
Unit = "year(s)",
},
Weight = new ParameterRange
{
Min = 70,
Unit = "kg",
},
GestationalAge = new ParameterRange
{
Min = 30,
Max = 35,
Unit = "week(s)",
},
NumberOfIndividuals = 10,
ProportionOfFemales = 70
};
}
public CreatePopulationResults CreatePopulation(PopulationCharacteristics populationCharacteristics)
{
var populationSettings = _populationSettingsMapper.MapToModel(populationCharacteristics, new SnapshotContext()).Result;
validate(populationSettings);
var population = _randomPopulationFactory.CreateFor(populationSettings, new CancellationToken(), seed: populationCharacteristics.Seed).Result;
foreach (var moleculeOntogeny in populationCharacteristics.MoleculeOntogenies)
{
var allOntogeniesForSpecies = _ontogenyRepository.AllFor(populationCharacteristics.Individual.OriginData.Species);
if (!allOntogeniesForSpecies.Any())
{
continue;
}
var ontogeny = allOntogeniesForSpecies.FindByName(moleculeOntogeny.Ontogeny);
if (ontogeny == null)
{
continue;
}
var molecule = _individualEnzymeFactory.CreateEmpty().WithName(moleculeOntogeny.Molecule);
molecule.Ontogeny = ontogeny;
population.AddMolecule(molecule);
}
_ontogenyVariabilityUpdater.UpdateAllOntogenies(population);
return(new CreatePopulationResults(population.IndividualValuesCache, population.Seed));
}
protected override void Context()
{
base.Context();
_populationCharacteristics = new PopulationCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.ICRP,
Age = new ParameterRange
{
Min = 20,
Max = 15,
Unit = "year(s)",
},
NumberOfIndividuals = 10,
ProportionOfFemales = 70
};
}
