private static void validateZoneValues(IndividualMolecule molecule)
{
CoreConstants.Compartment.LiverZones.Each(z =>
{
var expressionContainer = molecule.ExpressionContainer(z);
expressionContainer.OrganPath.PathAsString.ShouldBeEqualTo(new[] { Constants.ORGANISM, CoreConstants.Organ.Liver, z }.ToPathString());
expressionContainer.RelativeExpression.ShouldBeEqualTo(10);
expressionContainer.RelativeExpressionNorm.ShouldBeEqualTo(1);
expressionContainer.ContainerName = z;
});
}
private void updateOntogeny(IndividualMolecule molecule)
{
var liver = molecule.ExpressionContainer(CoreConstants.Organ.Liver);
if (liver == null)
{
return;
}
var ontogenyFactorLiver = liver.Parameter(CoreConstants.Parameters.ONTOGENY_FACTOR);
if (ontogenyFactorLiver != null)
{
molecule.Add(ontogenyFactorLiver);
}
IParameter ontogenyFactorDuodenum = null;
var duodenum = molecule.ExpressionContainer(CoreConstants.Compartment.Duodenum);
if (duodenum != null)
{
ontogenyFactorDuodenum = duodenum.Parameter(CoreConstants.Parameters.ONTOGENY_FACTOR);
}
//remove old ontogeny factor parameter in container
foreach (var expressionContainer in molecule.AllExpressionsContainers())
{
var ontogenyFactor = expressionContainer.Parameter(CoreConstants.Parameters.ONTOGENY_FACTOR);
if (ontogenyFactor != null)
{
expressionContainer.RemoveChild(ontogenyFactor);
}
}
if (ontogenyFactorDuodenum != null)
{
ontogenyFactorDuodenum.Name = CoreConstants.Parameters.ONTOGENY_FACTOR_GI;
molecule.Add(ontogenyFactorDuodenum);
}
}
private void updateLiverMoleculeExpression(IndividualMolecule molecule)
{
var liverContainer = molecule.ExpressionContainer(CoreConstants.Organ.Liver);
if (liverContainer == null)
{
return;
}
LIVER_ZONES.Each(z =>
{
var zoneContainer = _cloner.Clone(liverContainer).WithName(z);
zoneContainer.OrganPath.Add(z);
zoneContainer.ContainerName = z;
molecule.Add(zoneContainer);
});
molecule.RemoveChild(liverContainer);
}
