public void ActivateMolecule(IndividualMolecule molecule)
{
_transporter = molecule.DowncastTo <IndividualTransporter>();
_view.HideWarning();
_view.BindTo(_transporterExpressionDTOMapper.MapFrom(_transporter));
_moleculePropertiesPresenter.Edit(molecule, SimulationSubject.DowncastTo <TSimulationSubject>());
}
protected override void Context()
{
_context = A.Fake <IExecutionContext>();
var expressionProfile = DomainHelperForSpecs.CreateExpressionProfile <IndividualEnzyme>();
(_molecule, _) = expressionProfile;
_protein = _molecule.DowncastTo <IndividualProtein>();
_result = new QueryExpressionResults(_expressionResults);
_simulationSubject = A.Fake <ISimulationSubject>();
sut = new EditIndividualMoleculeExpressionInSimulationSubjectFromQueryCommand(_molecule, _result, _simulationSubject);
A.CallTo(() => _simulationSubject.AllExpressionParametersFor(_molecule)).Returns(_allExpressionParameters);
}
public void ActivateMolecule(IndividualMolecule molecule)
{
Activate(molecule.DowncastTo <TProtein>());
}
private IEnumerable <IContainer> allContainersFor(Organism organism, IndividualMolecule molecule, IEnumerable <IContainer> allContainers, IMoleculeExpressionContainer expressionContainer)
{
if (molecule.MoleculeType == QuantityType.Transporter)
{
return(allContainersForTransporter(organism, molecule.DowncastTo <IndividualTransporter>(), allContainers, expressionContainer.DowncastTo <ITransporterExpressionContainer>()));
}
var protein = molecule.DowncastTo <IndividualProtein>();
//plasma always generated
if (expressionContainer.IsPlasma())
{
return(allPlasmaCompartmentsOf(allContainers));
}
switch (protein.TissueLocation)
{
case TissueLocation.ExtracellularMembrane:
if (expressionContainer.IsBloodCell())
{
return(allPlasmaCompartmentsOf(allContainers));
}
if (expressionContainer.IsVascularEndothelium())
{
if (protein.MembraneLocation == MembraneLocation.Apical)
{
return(allPlasmaCompartmentsOf(allContainers));
}
return(allInterstitialCompartmentsOf(allContainers));
}
return(compartmentFor(organism, expressionContainer, CoreConstants.Compartment.Interstitial));
case TissueLocation.Intracellular:
if (expressionContainer.IsBloodCell())
{
return(allBloodCellsCompartmentsOf(allContainers));
}
if (expressionContainer.IsVascularEndothelium())
{
if (protein.IntracellularVascularEndoLocation == IntracellularVascularEndoLocation.Endosomal)
{
return(allEndosomeCompartmentsOf(allContainers));
}
return(allInterstitialCompartmentsOf(allContainers));
}
return(compartmentFor(organism, expressionContainer, CoreConstants.Compartment.Intracellular));
case TissueLocation.Interstitial:
if (expressionContainer.IsBloodCell())
{
return(allBloodCellsCompartmentsOf(allContainers));
}
if (expressionContainer.IsVascularEndothelium())
{
return(allInterstitialCompartmentsOf(allContainers));
}
return(compartmentFor(organism, expressionContainer, CoreConstants.Compartment.Interstitial));
default:
throw new ArgumentOutOfRangeException();
}
}
