private void drawSingleDRCToolStripMenuItem_Click(object sender, EventArgs e)
{
int NumberOfReplicate = 4;
int DRCNumberofPoints = 20;
cExtendedTable FullResults = new cExtendedTable();
FullResults.ListRowNames = new List<string>();
cExtendedList ListPValues = new cExtendedList("DRC");
cDataGeneratorTitration GT = new cDataGeneratorTitration();
GT.NumberOfPoint = DRCNumberofPoints;
GT.Start = 100;
GT.DilutionFactor = 3;
GT.Run();
Random RND = new Random();
cExtendedTable FinalTable = new cExtendedTable();
cDataGeneratorSigmoid DGS = null;
DGS = new cDataGeneratorSigmoid();
DGS.SetInputData(GT.GetOutPut()[0]);
DGS.EC50 = 0.01;
DGS.Bottom = 10;
DGS.Top = 110;
DGS.Slope = 1;
DGS.Run();
// cAddNoise AN = new cAddNoise();
// AN.DistributionType = eRandDistributionType.GAUSSIAN;
double NoiseLevel = 10;
// EXT[0].Add(NoiseLevel);
// EXT[1].Add(DGS.EC50);
#region loop over the replicates
for (int NumReplic = 0; NumReplic < NumberOfReplicate; NumReplic++)
{
cExtendedList NewL = DGS.GetOutPut()[1];
for (int k = 0; k < NewL.Count; k++)
{
NewL[k] += RND.NextDouble() * NoiseLevel;
}
cExtendedTable TmpTable = new cExtendedTable();
TmpTable.Add(GT.GetOutPut()[0]);
TmpTable.Add(NewL);
if (NumReplic >= 1)
{
cMerge M = new cMerge();
M.IsHorizontal = false;
M.SetInputData(TmpTable, FinalTable);
M.Run();
FinalTable = M.GetOutPut();
}
else
FinalTable = new cExtendedTable(TmpTable);
}
#endregion
cSigmoidFitting SF = new cSigmoidFitting();
SF.SetInputData(FinalTable);
SF.Run();
cGlobalInfo.ConsoleWriteLine("Slope :" + DGS.Slope + " - Evaluated:" + SF.GetOutPut()[0][3]);
cGlobalInfo.ConsoleWriteLine("Top :" + DGS.Top + " - Evaluated:" + SF.GetOutPut()[0][1]);
cGlobalInfo.ConsoleWriteLine("Bottom :" + DGS.Bottom + " - Evaluated:" + SF.GetOutPut()[0][0]);
cGlobalInfo.ConsoleWriteLine("EC50 :" + DGS.EC50 + " - Evaluated:" + SF.GetOutPut()[0][2]);
// return;
cCurveForGraph CFG = new cCurveForGraph();
CFG.SetInputData(FinalTable);
CFG.Run();
cExtendedTable Sigmoid = SF.GetFittedRawValues(GT.GetOutPut()[0]);
FinalTable[0] = Sigmoid[1];
cViewerGraph1D VS1 = new cViewerGraph1D();
VS1.SetInputData(new cExtendedTable(Sigmoid[1]));
VS1.AddCurve(CFG);
VS1.Chart.X_AxisValues = Sigmoid[0];//DGS.GetOutPut()[0];
VS1.Chart.IsLogAxis = true;
VS1.Chart.IsLine = true;
VS1.Chart.IsShadow = true;
VS1.Chart.Opacity = 210;
VS1.Chart.LineWidth = 3;
VS1.Chart.LabelAxisX = "Concentration";
VS1.Chart.LabelAxisY = "Readout";
VS1.Chart.XAxisFormatDigitNumber = -1;
VS1.Chart.IsZoomableX = true;
VS1.Chart.IsZoomableY = true;
VS1.Run();
cDesignerSinglePanel CD = new cDesignerSinglePanel();
CD.SetInputData(VS1.GetOutPut());
CD.Run();
cDisplayToWindow DTW = new cDisplayToWindow();
DTW.SetInputData(CD.GetOutPut());//DS.GetOutPut());
DTW.Run();
DTW.Display();
}
private void sigmoidFittToolStripMenuItem_Click(object sender, EventArgs e)
{
int NumberOfReplicate = 4;
int NumberOfCurves = 30;
int DRCNumberofPoints = 12;
cExtendedTable FullResults = new cExtendedTable();
FullResults.ListRowNames = new List<string>();
double RealEC50 = 0.0001;
int NumberOfDiffEC50 = 20;
int NumberOfSlopes = 100;
// for (int EC50 = 0; EC50 < NumberOfDiffEC50; EC50++)
{
//double TmpSlopeValue = 0.0;
for (int EC50 = 0; EC50 < NumberOfDiffEC50; EC50++)
//for (int SlopeTmp = 0; SlopeTmp < NumberOfSlopes; SlopeTmp++)
{
RealEC50 *= 2;
//TmpSlopeValue += 0.1;
cExtendedList ListPValues = new cExtendedList("EC50 - " + RealEC50/*TmpSlopeValue*/);
cDesignerTab DT = new cDesignerTab();
DT.IsMultiline = false;
cDataGeneratorTitration GT = new cDataGeneratorTitration();
GT.NumberOfPoint = DRCNumberofPoints;
GT.Start = 5;
GT.DilutionFactor = 2;
GT.Run();
Random RND = new Random();
//cExtendedTable EXT = new cExtendedTable();
//EXT.ListRowNames = new List<string>();
//EXT.Name = "Quality fitting Report";
//EXT.Add(new cExtendedList("Noise Level"));
//EXT.Add(new cExtendedList("Original EC50"));
//EXT.Add(new cExtendedList("Estimated EC50"));
//EXT.Add(new cExtendedList("p-Value"));
for (int i = 0; i < NumberOfCurves; i++)
{
cExtendedTable FinalTable = new cExtendedTable();
cDataGeneratorSigmoid DGS = null;
DGS = new cDataGeneratorSigmoid();
DGS.SetInputData(GT.GetOutPut()[0]);
DGS.EC50 = RealEC50;// 0.01;// 1;// 0.1;// Math.Pow((double)10, -2);
DGS.Bottom = 0;
DGS.Top = 100;
DGS.Slope = 2;// TmpSlopeValue;//1;
DGS.Run();
cAddNoise AN = new cAddNoise();
AN.DistributionType = eRandDistributionType.GAUSSIAN;
double NoiseLevel = (i + 1) * 5;
// EXT[0].Add(NoiseLevel);
// EXT[1].Add(DGS.EC50);
#region loop over the replicates
for (int NumReplic = 0; NumReplic < NumberOfReplicate; NumReplic++)
{
//AN.Mean = 0;
//AN.Stdv = 10;
//AN.SetInputData(DGS.GetOutPut());
//AN.Run();
cExtendedList NewL = DGS.GetOutPut()[1];
for (int k = 0; k < NewL.Count; k++)
{
NewL[k] += RND.NextDouble() * NoiseLevel;
}
cExtendedTable TmpTable = new cExtendedTable();
TmpTable.Add(GT.GetOutPut()[0]);
TmpTable.Add(/*AN.GetOutPut()[1]*/NewL);
if (NumReplic >= 1)
{
cMerge M = new cMerge();
M.IsHorizontal = false;
M.SetInputData(TmpTable, FinalTable);
M.Run();
FinalTable = M.GetOutPut();
}
else
FinalTable = new cExtendedTable(TmpTable);
}
#endregion
//cListWell LW = new cListWell(null);
//foreach (cWell item in CompleteScreening.GetCurrentDisplayPlate().ListActiveWells)
//{
// if (item.GetClassIdx() == 0)
// LW.Add(item);
//}
//cExtendedTable ET = LW.GetDescriptorValues(CompleteScreening.ListDescriptors.GetActiveDescriptors(), true);
cCurveForGraph CFG = new cCurveForGraph();
CFG.SetInputData(FinalTable);
CFG.Run();
// compute ANOVA
cANOVA S = new cANOVA();
cExtendedTable NewTable = CFG.ListPtValues.Crop(0, CFG.ListPtValues.Count - 1, 1, CFG.ListPtValues[0].Count - 1);
S.SignificanceThreshold = 1E-11;
S.SetInputData(NewTable);
S.Run();
//cLinearRegression LR = new cLinearRegression();
//LR.SetInputData(FinalTable);
//LR.Run();
cSigmoidFitting SF = new cSigmoidFitting();
SF.SetInputData(FinalTable);
if (SF.Run().IsSucceed == false) continue;
// double Ratio = LR.GetOutPut()[0][LR.GetOutPut().Count - 1] / SF.GetOutPut()[0][SF.GetOutPut().Count - 1];
cExtendedTable Sigmoid = SF.GetFittedRawValues(GT.GetOutPut()[0]);
FinalTable[0] = Sigmoid[1];
cDesignerSplitter DS = new cDesignerSplitter();
////cViewerTableAsRichText VT = new cViewerTableAsRichText();
cViewerTable VT = new cViewerTable();
cExtendedTable TableResults = SF.GetOutPut();
TableResults[0].Add(S.GetOutPut()[0][0]);
ListPValues.Add(S.GetOutPut()[0][0]);
TableResults[0].Add(S.GetOutPut()[0][1]);
TableResults.ListRowNames.Add("p-Value");
TableResults.ListRowNames.Add("Null hyp. rejected?");
VT.SetInputData(TableResults);
VT.DigitNumber = -1;
VT.Run();
cViewerGraph1D VS1 = new cViewerGraph1D();
VS1.SetInputData(new cExtendedTable(Sigmoid[1]));
VS1.AddCurve(CFG);
VS1.Chart.X_AxisValues = Sigmoid[0];//DGS.GetOutPut()[0];
VS1.Chart.IsLogAxis = true;
VS1.Chart.IsLine = true;
VS1.Chart.IsShadow = true;
VS1.Chart.Opacity = 210;
VS1.Chart.LineWidth = 3;
VS1.Chart.LabelAxisX = "Concentration";
VS1.Chart.LabelAxisY = "Readout";
VS1.Chart.XAxisFormatDigitNumber = -1;
VS1.Chart.IsZoomableX = true;
//Classes.Base_Classes.General.cLineVerticalForGraph VLForEC50 = new Classes.Base_Classes.General.cLineVerticalForGraph(SF.GetOutPut()[0][2]);
//VLForEC50.AddText("EC50: " + SF.GetOutPut()[0][2].ToString("e3")/* + "\nError Ratio:" + Ratio.ToString("N4")*/);
//VS1.Chart.ListVerticalLines.Add(VLForEC50);
//VS1.Chart.ArraySeriesInfo = new cSerieInfoDesign[FinalTable.Count];
//EXT[2].Add(SF.GetOutPut()[0][2]);
//EXT[3].Add(S.GetOutPut()[0][0]);
//for (int IdxCurve = 0; IdxCurve < FinalTable.Count; IdxCurve++)
//{
// cSerieInfoDesign TmpSerieInfo = new cSerieInfoDesign();
// TmpSerieInfo.color = Color.FromArgb(100, GlobalInfo.ListCellularPhenotypes[IdxCurve % GlobalInfo.ListCellularPhenotypes.Count].ColourForDisplay);
// TmpSerieInfo.markerStyle = MarkerStyle.Circle;
// VS1.Chart.ArraySeriesInfo[IdxCurve] = TmpSerieInfo;
//}
VS1.Run();
DS.SetInputData(VS1.GetOutPut());
DS.SetInputData(VT.GetOutPut());
DS.Orientation = Orientation.Horizontal;
DS.Title = "Noise Stdev " + NoiseLevel;
DS.Run();
DT.SetInputData(DS.GetOutPut());
// EXT.ListRowNames.Add(DS.Title);
}
DT.Run();
//cDisplayToWindow DTW = new cDisplayToWindow();
//DTW.SetInputData(DT.GetOutPut());
//DTW.Run();
//DTW.Display();
//cDisplayExtendedTable DET = new cDisplayExtendedTable();
//DET.SetInputData(EXT);
//DET.DigitNumber = -1;
//DET.Run();
FullResults.Add(ListPValues);
}
}
cDisplayExtendedTable DET = new cDisplayExtendedTable();
DET.SetInputData(FullResults);
DET.DigitNumber = -1;
DET.Run();
}
public void AddCurve(cCurveForGraph NewCurve)
{
Chart.ListCurves.Add(NewCurve);
}
void Process()
{
cDesignerTab DT = new cDesignerTab();
for (int i = 0; i < this.Input.Count; i++)
{
cExtendedTable FinalTable = this.Input[i];
cCurveForGraph CFG = new cCurveForGraph();
CFG.SetInputData(FinalTable);
CFG.Run();
//cLinearRegression LR = new cLinearRegression();
//LR.SetInputData(FinalTable);
//LR.Run();
cSigmoidFitting SF = new cSigmoidFitting();
SF.SetInputData(FinalTable);
if (SF.Run().IsSucceed == false) continue;
// double Ratio = LR.GetOutPut()[0][LR.GetOutPut().Count - 1] / SF.GetOutPut()[0][SF.GetOutPut().Count - 1];
cExtendedTable Sigmoid = SF.GetFittedRawValues(CFG.GetListXValues());
FinalTable[0] = Sigmoid[1];
cDesignerSplitter DS = new cDesignerSplitter();
//cViewerTableAsRichText VT = new cViewerTableAsRichText();
cViewerTable VT = new cViewerTable();
VT.SetInputData(SF.GetOutPut());
VT.DigitNumber = -1;
VT.Run();
cViewerGraph1D VS1 = new cViewerGraph1D();
//VS1.SetInputData(/*new cExtendedTable(AN.GetOutPut()[1])*/FinalTable);
VS1.SetInputData(new cExtendedTable(Sigmoid[1]));
VS1.AddCurve(CFG);
VS1.Chart.X_AxisValues = Sigmoid[0];//DGS.GetOutPut()[0];
VS1.Chart.IsLogAxis = true;
VS1.Chart.IsLine = true;
VS1.Chart.IsShadow = true;
VS1.Chart.Opacity = 210;
VS1.Chart.LineWidth = 3;
//VS1.Chart.IsDisplayValues = true;
VS1.Chart.LabelAxisX = "Concentration";
VS1.Chart.LabelAxisY = "Readout";
VS1.Chart.XAxisFormatDigitNumber = -1;
VS1.Chart.IsZoomableX = true;
Classes.Base_Classes.General.cLineVerticalForGraph VLForEC50 = new Classes.Base_Classes.General.cLineVerticalForGraph(SF.GetOutPut()[0][2]);
VLForEC50.AddText("EC50: " + SF.GetOutPut()[0][2].ToString("e3")/* + "\nError Ratio:" + Ratio.ToString("N4")*/);
VS1.Chart.ListVerticalLines.Add(VLForEC50);
VS1.Chart.ArraySeriesInfo = new cSerieInfoDesign[FinalTable.Count];
for (int IdxCurve = 0; IdxCurve < FinalTable.Count; IdxCurve++)
{
cSerieInfoDesign TmpSerieInfo = new cSerieInfoDesign();
// TmpSerieInfo.color = GlobalInfo.ListCellularPhenotypes[IdxCurve % GlobalInfo.ListCellularPhenotypes.Count].ColourForDisplay;
TmpSerieInfo.markerStyle = MarkerStyle.Circle;
VS1.Chart.ArraySeriesInfo[IdxCurve] = TmpSerieInfo;
}
VS1.Run();
DS.SetInputData(VS1.GetOutPut());
DS.SetInputData(VT.GetOutPut());
DS.Orientation = Orientation.Horizontal;
DS.Title = "Noise Stdev" + i * 10;
DS.Run();
DT.SetInputData(DS.GetOutPut());
}
DT.Run();
cDisplayToWindow MyDisplay = new cDisplayToWindow();
MyDisplay.SetInputData(DT.GetOutPut());
MyDisplay.Title = this.Input.Name;
MyDisplay.Run();
MyDisplay.Display();
}
void ToolStripMenuItem_DRCAnalysis_Click(object sender, EventArgs e)
{
List<cDescriptorType> ListSelectedDesc = new List<cDescriptorType>();// GlobalInfo.CurrentScreening.ListDescriptors.GetActiveDescriptors();
ListSelectedDesc.Add(cGlobalInfo.CurrentScreening.ListDescriptors.GetActiveDescriptor());
//if (GlobalInfo == null) GlobalInfo = cGlobalInfo.CurrentScreening.GlobalInfo;
//if (cGlobalInfo == null) return;
cDesignerMultiChoices DT = new cDesignerMultiChoices();
cExtendedTable TableForGeneralResuts = new cExtendedTable();
TableForGeneralResuts.Add(new cExtendedList("p-Value"));
TableForGeneralResuts.Add(new cExtendedList("EC50"));
TableForGeneralResuts.Add(new cExtendedList("Slope"));
TableForGeneralResuts.Add(new cExtendedList("Bottom"));
TableForGeneralResuts.Add(new cExtendedList("Top"));
TableForGeneralResuts.Add(new cExtendedList("Window"));
TableForGeneralResuts.Add(new cExtendedList("Area Under Curve"));
TableForGeneralResuts.ListRowNames = new List<string>();
TableForGeneralResuts.ListTags = new List<object>();
cDesignerSplitter MainSplitter = new cDesignerSplitter();
int IdxNode = 0;
cListListWells CurrentSelectedGroups = this.BuildListListWells();
foreach (cListWells TmpListWells in CurrentSelectedGroups)
{
// List<cDescriptorType> LType = new List<cDescriptorType>();
// LType.Add(ListSelectedDesc[i]);
cExtendedTable CompleteTable = TmpListWells.GetAverageDescriptorValues(ListSelectedDesc, true, false);
//cExtendedTable CompleteTable = GLP.GetOutPut();
cCurveForGraph CFG = new cCurveForGraph();
CFG.SetInputData(CompleteTable);
CFG.Run();
cSigmoidFitting SF = new cSigmoidFitting();
SF.SetInputData(CompleteTable);
if (SF.Run().IsSucceed == false) continue;
// double Ratio = LR.GetOutPut()[0][LR.GetOutPut().Count - 1] / SF.GetOutPut()[0][SF.GetOutPut().Count - 1];
cANOVA A = new cANOVA();
cExtendedTable NewTable = CFG.ListPtValues.Crop(0, CFG.ListPtValues.Count - 1, 1, CFG.ListPtValues[0].Count - 1);
A.SignificanceThreshold = 1E-11;
A.SetInputData(NewTable);
A.Run();
cExtendedTable Sigmoid = SF.GetFittedRawValues(CFG.GetListXValues());
CompleteTable[0] = Sigmoid[1];
CompleteTable[0].Name = ListSelectedDesc[0].GetName() + "\n" + Sigmoid[1].Name;
cDesignerSplitter DS = new cDesignerSplitter();
//cViewerTableAsRichText VT = new cViewerTableAsRichText();
cViewerTable VT = new cViewerTable();
cExtendedTable TableResults = SF.GetOutPut();
if ((A.GetOutPut() != null) && (A.GetOutPut().Count > 0))
{
TableResults[0].Add(A.GetOutPut()[0][0]);
TableResults[0].Add(A.GetOutPut()[0][1]);
TableResults.ListRowNames.Add("p-Value");
TableResults.ListRowNames.Add("Rejected?");
TableForGeneralResuts[0].Add(A.GetOutPut()[0][0]);
}
else
{
TableForGeneralResuts[0].Add(1);
}
TableResults.Name = TV.Nodes[IdxNode].Text;
TableResults[0].Name = "Fitting Parameters";
VT.SetInputData(TableResults);
VT.DigitNumber = -1;
VT.Run();
cViewerGraph1D VS1 = new cViewerGraph1D();
cExtendedTable MyTable = new cExtendedTable(Sigmoid[1]);
MyTable.Name = TmpListWells.Name;// TV.Nodes[IdxNode].Text;
VS1.SetInputData(MyTable);
VS1.AddCurve(CFG);
VS1.Chart.X_AxisValues = Sigmoid[0];
VS1.Chart.IsLogAxis = true;
VS1.Chart.IsLine = true;
VS1.Chart.IsShadow = false;
VS1.Chart.Opacity = 210;
VS1.Chart.LineWidth = 3;
VS1.Chart.MarkerSize = 8;
VS1.Chart.IsDisplayValues = cGlobalInfo.OptionsWindow.FFAllOptions.checkBoxDRCDisplayValues.Checked;
VS1.Chart.LabelAxisX = "Concentration";
VS1.Chart.LabelAxisY = CompleteTable[1].Name;
VS1.Chart.XAxisFormatDigitNumber = cGlobalInfo.OptionsWindow.FFAllOptions.GetDRCNumberOfDigit();
VS1.Chart.IsZoomableX = true;
Classes.Base_Classes.General.cLineVerticalForGraph VLForEC50 = new Classes.Base_Classes.General.cLineVerticalForGraph(SF.GetOutPut()[0][2]);
//VLForEC50.AddText("EC50: " + SF.GetOutPut()[0][2].ToString("e3")/* + "\nError Ratio:" + Ratio.ToString("N4")*/);
VS1.Chart.ListVerticalLines.Add(VLForEC50);
TableForGeneralResuts.ListRowNames.Add(TV.Nodes[IdxNode].Text);
TableForGeneralResuts.ListTags.Add((Chart)VS1.Chart);//ListSelectedDesc[0]);
//EC50
TableForGeneralResuts[1].Add(SF.GetOutPut()[0][2]);
// Slope
TableForGeneralResuts[2].Add(SF.GetOutPut()[0][3]);
// Bottom
TableForGeneralResuts[3].Add(SF.GetOutPut()[0][0]);
// Top
TableForGeneralResuts[4].Add(SF.GetOutPut()[0][1]);
// Window
double Window = SF.GetOutPut()[0][1] / SF.GetOutPut()[0][0];
TableForGeneralResuts[5].Add(Window);
TableForGeneralResuts[6].Add(SF.GetOutPut()[0][5]);
VS1.Chart.ArraySeriesInfo = new cSerieInfoDesign[CompleteTable.Count];
for (int IdxCurve = 0; IdxCurve < CompleteTable.Count; IdxCurve++)
{
cSerieInfoDesign TmpSerieInfo = new cSerieInfoDesign();
TmpSerieInfo.color = cGlobalInfo.ListCellularPhenotypes[IdxCurve % cGlobalInfo.ListCellularPhenotypes.Count].ColourForDisplay;
TmpSerieInfo.markerStyle = MarkerStyle.None;
VS1.Chart.ArraySeriesInfo[IdxCurve] = TmpSerieInfo;
}
VS1.Run();
DS.SetInputData(VS1.GetOutPut());
DS.SetInputData(VT.GetOutPut());
DS.Orientation = Orientation.Horizontal;
DS.Title = TV.Nodes[IdxNode++].Text; //TmpListWells.ti;// ListSelectedDesc[0].GetName();
DS.Run();
DT.SetInputData(DS.GetOutPut());
}
DT.Run();
cExtendedControl TextEC = DT.GetOutPut();
if (TextEC == null) return;
TextEC.Width = 0;
TextEC.Height = 0;
TextEC.Anchor = (System.Windows.Forms.AnchorStyles)(System.Windows.Forms.AnchorStyles.Top | System.Windows.Forms.AnchorStyles.Bottom
| System.Windows.Forms.AnchorStyles.Left | System.Windows.Forms.AnchorStyles.Right);
MainSplitter.SetInputData(TextEC);
string DRCsortingMethod = cGlobalInfo.OptionsWindow.FFAllOptions.comboBoxDRCSorting.SelectedItem.ToString();
//comboBoxDRCSorting
int IdxColSorting = 0;
cExtendedTable RT = TableForGeneralResuts;
switch (DRCsortingMethod)
{
case "ANOVA":
IdxColSorting = 0;
break;
case "EC50":
IdxColSorting = 1;
break;
case "Window":
IdxColSorting = 5;
break;
case "AUC":
IdxColSorting = 6;
break;
case "None":
IdxColSorting = -1;
break;
default:
break;
}
if (IdxColSorting != -1)
{
cSort S = new cSort();
S.ColumnIndexForSorting = IdxColSorting;
S.SetInputData(TableForGeneralResuts);
S.IsAscending = true;
S.Run();
RT = S.GetOutPut();
}
cViewerTable VTForEC50 = new cViewerTable();
RT.Name = cGlobalInfo.CurrentScreening.ListDescriptors.GetActiveDescriptor().GetName();
VTForEC50.SetInputData(RT);
VTForEC50.DigitNumber = -1;
VTForEC50.Run();
MainSplitter.SetInputData(VTForEC50.GetOutPut());
MainSplitter.Orientation = Orientation.Vertical;
MainSplitter.Run();
cDisplayToWindow DTW = new cDisplayToWindow();
DTW.SetInputData(MainSplitter.GetOutPut());
DTW.Title = "DRC analysis [" + cGlobalInfo.CurrentScreening.ListDescriptors.GetActiveDescriptor().GetName() + "]";
DTW.Run();
DTW.Display();
}
void ToolStripMenuItem_DRCAnalysisMultiDesc_Click(object sender, EventArgs e)
{
List<cDescriptorType> ListSelectedDescs = cGlobalInfo.CurrentScreening.ListDescriptors.GetActiveDescriptors();
cListListWells CurrentSelectedGroups = this.BuildListListWells();
#region select folder
var dlg1 = new Ionic.Utils.FolderBrowserDialogEx();
dlg1.Description = "Select the folder containing your databases.";
dlg1.ShowNewFolderButton = true;
dlg1.ShowEditBox = true;
dlg1.ShowFullPathInEditBox = true;
DialogResult result = dlg1.ShowDialog();
if (result != DialogResult.OK) return;
string Path = dlg1.SelectedPath;
if (Directory.Exists(Path) == false) return;
string FolderName = dlg1.SelectedPath;
#endregion
foreach (var item in ListSelectedDescs)
{
string TmpFolder = FolderName + "\\" + item.GetName();
Directory.CreateDirectory(TmpFolder);
int IdxNode = 0;
List<cDescriptorType> ListSelectedDesc = new List<cDescriptorType>();
ListSelectedDesc.Add(item);
cExtendedTable TableForGeneralResuts = new cExtendedTable();
TableForGeneralResuts.Add(new cExtendedList("p-Value"));
TableForGeneralResuts.Add(new cExtendedList("EC50"));
TableForGeneralResuts.Add(new cExtendedList("Slope"));
TableForGeneralResuts.Add(new cExtendedList("Bottom"));
TableForGeneralResuts.Add(new cExtendedList("Top"));
TableForGeneralResuts.Add(new cExtendedList("Window"));
TableForGeneralResuts.Add(new cExtendedList("Area Under Curve"));
TableForGeneralResuts.ListRowNames = new List<string>();
TableForGeneralResuts.ListTags = new List<object>();
foreach (cListWells TmpListWells in CurrentSelectedGroups)
{
// List<cDescriptorType> LType = new List<cDescriptorType>();
// LType.Add(ListSelectedDesc[i]);
cExtendedTable CompleteTable = TmpListWells.GetAverageDescriptorValues(ListSelectedDesc, true, false);
//cExtendedTable CompleteTable = GLP.GetOutPut();
cCurveForGraph CFG = new cCurveForGraph();
CFG.SetInputData(CompleteTable);
CFG.Run();
cSigmoidFitting SF = new cSigmoidFitting();
SF.SetInputData(CompleteTable);
if (SF.Run().IsSucceed == false) continue;
// double Ratio = LR.GetOutPut()[0][LR.GetOutPut().Count - 1] / SF.GetOutPut()[0][SF.GetOutPut().Count - 1];
cANOVA A = new cANOVA();
cExtendedTable NewTable = CFG.ListPtValues.Crop(0, CFG.ListPtValues.Count - 1, 1, CFG.ListPtValues[0].Count - 1);
A.SignificanceThreshold = 1E-11;
A.SetInputData(NewTable);
A.Run();
cExtendedTable Sigmoid = SF.GetFittedRawValues(CFG.GetListXValues());
CompleteTable[0] = Sigmoid[1];
CompleteTable[0].Name = ListSelectedDesc[0].GetName() + "\n" + Sigmoid[1].Name;
cDesignerSplitter DS = new cDesignerSplitter();
//cViewerTableAsRichText VT = new cViewerTableAsRichText();
cViewerTable VT = new cViewerTable();
cExtendedTable TableResults = SF.GetOutPut();
if ((A.GetOutPut() != null) && (A.GetOutPut().Count > 0))
{
TableResults[0].Add(A.GetOutPut()[0][0]);
TableResults[0].Add(A.GetOutPut()[0][1]);
TableResults.ListRowNames.Add("p-Value");
TableResults.ListRowNames.Add("Rejected?");
TableForGeneralResuts[0].Add(A.GetOutPut()[0][0]);
}
else
{
TableForGeneralResuts[0].Add(1);
}
TableResults.Name = TV.Nodes[IdxNode].Text;
TableResults[0].Name = "Fitting Parameters";
VT.SetInputData(TableResults);
VT.DigitNumber = -1;
VT.Run();
cViewerGraph1D VS1 = new cViewerGraph1D();
cExtendedTable MyTable = new cExtendedTable(Sigmoid[1]);
MyTable.Name = TmpListWells.Name;// TV.Nodes[IdxNode].Text;
VS1.SetInputData(MyTable);
VS1.AddCurve(CFG);
VS1.Chart.X_AxisValues = Sigmoid[0];
VS1.Chart.IsLogAxis = true;
VS1.Chart.IsLine = true;
VS1.Chart.IsShadow = false;
VS1.Chart.Opacity = 210;
VS1.Chart.LineWidth = 3;
VS1.Chart.MarkerSize = 8;
VS1.Chart.IsDisplayValues = cGlobalInfo.OptionsWindow.FFAllOptions.checkBoxDRCDisplayValues.Checked;
VS1.Chart.LabelAxisX = "Concentration";
VS1.Chart.LabelAxisY = CompleteTable[1].Name;
VS1.Chart.XAxisFormatDigitNumber = cGlobalInfo.OptionsWindow.FFAllOptions.GetDRCNumberOfDigit();
VS1.Chart.IsZoomableX = true;
Classes.Base_Classes.General.cLineVerticalForGraph VLForEC50 = new Classes.Base_Classes.General.cLineVerticalForGraph(SF.GetOutPut()[0][2]);
//VLForEC50.AddText("EC50: " + SF.GetOutPut()[0][2].ToString("e3")/* + "\nError Ratio:" + Ratio.ToString("N4")*/);
VS1.Chart.ListVerticalLines.Add(VLForEC50);
TableForGeneralResuts.ListRowNames.Add(TV.Nodes[IdxNode].Text);
TableForGeneralResuts.ListTags.Add((Chart)VS1.Chart);//ListSelectedDesc[0]);
//EC50
TableForGeneralResuts[1].Add(SF.GetOutPut()[0][2]);
// Slope
TableForGeneralResuts[2].Add(SF.GetOutPut()[0][3]);
// Bottom
TableForGeneralResuts[3].Add(SF.GetOutPut()[0][0]);
// Top
TableForGeneralResuts[4].Add(SF.GetOutPut()[0][1]);
// Window
double Window = SF.GetOutPut()[0][1] / SF.GetOutPut()[0][0];
TableForGeneralResuts[5].Add(Window);
TableForGeneralResuts[6].Add(SF.GetOutPut()[0][5]);
VS1.Chart.ArraySeriesInfo = new cSerieInfoDesign[CompleteTable.Count];
for (int IdxCurve = 0; IdxCurve < CompleteTable.Count; IdxCurve++)
{
cSerieInfoDesign TmpSerieInfo = new cSerieInfoDesign();
TmpSerieInfo.color = cGlobalInfo.ListCellularPhenotypes[IdxCurve % cGlobalInfo.ListCellularPhenotypes.Count].ColourForDisplay;
TmpSerieInfo.markerStyle = MarkerStyle.None;
VS1.Chart.ArraySeriesInfo[IdxCurve] = TmpSerieInfo;
}
VS1.Run();
//DS.SetInputData(VS1.GetOutPut());
//DS.SetInputData(VT.GetOutPut());
//DS.Orientation = Orientation.Horizontal;
//DS.Title = TV.Nodes[IdxNode++].Text; //TmpListWells.ti;// ListSelectedDesc[0].GetName();
//DS.Run();
IdxNode++;
// DT.SetInputData(DS.GetOutPut());
}
cTableToHTML THTML = new cTableToHTML();
TableForGeneralResuts.Name = item.GetName();
THTML.SetInputData(TableForGeneralResuts);
THTML.IsDisplayUIForFilePath = false;
THTML.FolderName = TmpFolder;
THTML.ListProperties.FindByName("Open HTML File ?").SetNewValue((bool)false);
THTML.ListProperties.FindByName("Open HTML File ?").IsGUIforValue = false;
THTML.Run();
}
System.Diagnostics.Process.Start(FolderName);
}
