private void addPKParametersForOutput(ISimulation simulation, int numberOfIndividuals, SimulationResults runResults, Action <int> performIndividualScalingAction,
QuantitySelection selectedQuantity, PopulationSimulationPKAnalyses popAnalyses, string moleculeName,
PKCalculationOptions pkCalculationOptions, IReadOnlyList <PKCalculationOptionsFactory.ApplicationParameters> allApplicationParameters)
{
var availablePKParameters = _pkParameterRepository.All().Where(p => PKParameterCanBeUsed(p, pkCalculationOptions)).ToList();
//create pk parameter for each quantities
foreach (var pkParameter in availablePKParameters)
{
var quantityPKParameter = new QuantityPKParameter {
Name = pkParameter.Name, QuantityPath = selectedQuantity.Path, Dimension = pkParameter.Dimension
};
quantityPKParameter.SetNumberOfIndividuals(numberOfIndividuals);
popAnalyses.AddPKAnalysis(quantityPKParameter);
}
//add the values for each individual
foreach (var individualResult in runResults.AllIndividualResults)
{
performIndividualScalingAction(individualResult.IndividualId);
_pkCalculationOptionsFactory.UpdateAppliedDose(simulation, moleculeName, pkCalculationOptions, allApplicationParameters);
var values = individualResult.ValuesFor(selectedQuantity.Path);
var pkValues = _pkValuesCalculator.CalculatePK(individualResult.Time.Values, values.Values, pkCalculationOptions);
foreach (var pkParameter in availablePKParameters)
{
var quantityPKParameter = popAnalyses.PKParameterFor(selectedQuantity.Path, pkParameter.Name);
quantityPKParameter.SetValue(individualResult.IndividualId, pkValues.ValueOrDefaultFor(pkParameter.Name));
}
}
}
public void should_be_able_to_calculate_the_pk_parameters_for_the_successful_simulations()
{
_pkAnalysis.ShouldNotBeNull();
var values = _pkAnalysis.PKParameterFor(_outputPath, "C_max");
values.Count.ShouldBeEqualTo(4);
}
public void should_not_create_more_entries_in_the_returns_value_that_expected()
{
_pkAnalysis.ShouldNotBeNull();
var values = _pkAnalysis.PKParameterFor(_outputPath, "C_max");
values.Count.ShouldBeEqualTo(5);
float.IsNaN(values.ValueFor(3)).ShouldBeTrue();
}
public void should_exclude_the_norm_parameters()
{
_popAnalaysis.All().Count().ShouldBeEqualTo(1);
_popAnalaysis.PKParameterFor("Liver|Cell|Drug|Concentration", _p1.Name).Values[0].ShouldBeEqualTo(10f);
_popAnalaysis.HasPKParameterFor("Liver|Cell|Drug|Concentration", _p2.Name).ShouldBeFalse();
}
public void should_have_converted_display_dimension_into_core_dimension()
{
var c_max = _result.PKParameterFor(_outputPath, "C_max");
c_max.Dimension.Name.ShouldBeEqualTo(Constants.Dimension.MOLAR_CONCENTRATION);
}
public void should_be_able_to_calculate_the_normalized_values()
{
var pkParameter = _pkAnalysis.PKParameterFor("Organism|PeripheralVenousBlood|C1|Plasma (Peripheral Venous Blood)", "C_max_tD1_tD2_norm");
pkParameter.ValueFor(0).ShouldBeGreaterThan(0);
}
public void should_also_return_value_for_the_dynamic_parameters()
{
_popAnalysis.All().Count().ShouldBeEqualTo(2);
_popAnalysis.PKParameterFor("Liver|Cell|Drug|Concentration", _p1.Name).ValueFor(0).ShouldBeEqualTo(10f);
_popAnalysis.PKParameterFor("Liver|Cell|Drug|Concentration", _userDefinedParameter1.Name).ValueFor(0).ShouldBeEqualTo(30f);
}