private void ProteaseSpecificUpdate(object sender, SelectionChangedEventArgs e)
{
string proteaseName = ((Protease)ProteaseComboBox.SelectedItem).Name;
MissedCleavagesTextBox.IsEnabled = !proteaseName.Equals("top-down");
if (AutomaticallyAskAndOrUpdateParametersBasedOnProtease)
{
switch (proteaseName)
{
case "non-specific":
if (UpdateGUISettings.UseNonSpecificRecommendedSettings())
{
MaxPeptideLengthTextBox.Text = "25";
}
break;
case "top-down":
if (UpdateGUISettings.UseTopDownRecommendedSettings())
{
//many variables are not present in the calibrate task gui, but we modify them when saving
//uncheck all variable mods
foreach (var mod in VariableModTypeForTreeViewObservableCollection)
{
mod.Use = false;
}
}
break;
case "Arg-C":
if (UpdateGUISettings.UseArgCRecommendedSettings())
{
ProteaseComboBox.SelectedItem = ProteaseDictionary.Dictionary["trypsin"];
}
break;
case "chymotrypsin (don't cleave before proline)":
case "chymotrypsin (cleave before proline)":
{
if (UpdateGUISettings.UseChymotrypsinRecommendedSettings())
{
MissedCleavagesTextBox.Text = "3";
}
}
break;
case "elastase":
{
if (UpdateGUISettings.UseElastaseRecommendedSettings())
{
MissedCleavagesTextBox.Text = "16";
}
}
break;
//nothing to change for semi-trypsin
default:
break;
}
}
}
private void ProteaseSpecificUpdate(object sender, SelectionChangedEventArgs e)
{
string proteaseName = ((Protease)ProteaseComboBox.SelectedItem).Name;
MissedCleavagesTextBox.IsEnabled = !proteaseName.Equals("top-down");
if (AutomaticallyAskAndOrUpdateParametersBasedOnProtease)
{
switch (proteaseName)
{
case "non-specific":
if (UpdateGUISettings.UseNonSpecificRecommendedSettings())
{
MaxPeptideLengthTextBox.Text = "25";
}
break;
case "top-down":
if (UpdateGUISettings.UseTopDownRecommendedSettings())
{
UseProvidedPrecursor.IsChecked = false;
DeconvolutionMaxAssumedChargeStateTextBox.Text = "60";
TrimMsMs.IsChecked = false;
//uncheck all variable mods
foreach (var mod in VariableModTypeForTreeViewObservableCollection)
{
mod.Use = false;
}
//clear GPTMD mods and replace them with a subset
foreach (var mod in GptmdModTypeForTreeViewObservableCollection)
{
mod.Use = false;
}
//populate the recommended mods
foreach (var mod in UpdateGUISettings.TopDownModsForGPTMD)
{
ModTypeForTreeView theModType = GptmdModTypeForTreeViewObservableCollection.FirstOrDefault(b => b.DisplayName.Equals(mod.Item1));
if (theModType != null)
{
var theMod = theModType.Children.FirstOrDefault(b => b.ModName.Equals(mod.Item2));
if (theMod != null)
{
theMod.Use = true;
}
}
}
}
break;
case "Arg-C":
if (UpdateGUISettings.UseArgCRecommendedSettings())
{
ProteaseComboBox.SelectedItem = ProteaseDictionary.Dictionary["trypsin"];
}
break;
case "chymotrypsin (don't cleave before proline)":
case "chymotrypsin (cleave before proline)":
{
if (UpdateGUISettings.UseChymotrypsinRecommendedSettings())
{
MissedCleavagesTextBox.Text = "3";
}
}
break;
case "elastase":
{
if (UpdateGUISettings.UseElastaseRecommendedSettings())
{
MissedCleavagesTextBox.Text = "16";
}
}
break;
//nothing to change for semi-trypsin
default:
break;
}
}
}
