public void HelicalWheelBuilderThreeLetter(string aminoAcids, SKCanvas canvas)
{
var aminoClass = new AminoAcids();
var listAminos = aminoAcids.Split(',').ToList();
float xval = 0; float yval = 0;
float xModifier = 0; float yModifier = 0;
float modIncrementer = 0;
float scaleModifier = 19;
int angle = 270;
bool polarity = false;
string lastAmino = "";
int incr = 1;
var percentDiff = (App.ScreenHeight / ScaleFactor);
foreach (var item in listAminos)
{
if (!string.IsNullOrWhiteSpace(item))
{
if (!string.IsNullOrWhiteSpace(lastAmino))
{
if (incr < 18)
{
canvas.DrawLine(xval, yval, (float)((RADIUS * percentDiff) * Math.Cos(angle * Math.PI / 180F)), (float)((RADIUS * percentDiff) * Math.Sin(angle * Math.PI / 180F)), Line);
}
if (polarity)
{
canvas.DrawText(lastAmino.Substring(0, 1).ToString().ToUpper() + lastAmino.Substring(1, 2) + incr, xval - 7, yval + 4, PolarLetters);
}
else
{
canvas.DrawText(lastAmino.Substring(0, 1).ToString().ToUpper() + lastAmino.Substring(1, 2) + incr, xval - 7, yval + 4, NonPolarLetters);
}
incr += 1;
}
xval = (float)((RADIUS * percentDiff) * Math.Cos(angle * Math.PI / 180F));
yval = (float)((RADIUS * percentDiff) * Math.Sin(angle * Math.PI / 180F));
HelicalStructure.Add(new KeyValuePair <string, Point>(item.Substring(0, 1).ToString().ToUpper() + item.Substring(1, 2) + incr, new Point(xval, yval)));
if (incr % scaleModifier == 0)
{
modIncrementer += 1;
scaleModifier = scaleModifier + 18;
}
xModifier = xval > 0 ? 13f * modIncrementer : -13f * modIncrementer;
yModifier = yval > 0 ? 13f * modIncrementer : -13f * modIncrementer;
if (Math.Abs(xval) < 5 && modIncrementer > 0)
{
yModifier = yModifier > 0 ? (yModifier - .5f) + (6 * modIncrementer) : (yModifier + .5f) - (6 * modIncrementer);
xModifier = 0;
}
xval += xModifier;
yval += yModifier;
if (aminoClass.IsAminoAcid(item))
{
if (polarity = aminoClass.IsPolar(item))
{
canvas.DrawCircle(xval, yval, (AMINORADIUS * percentDiff), PolarAminoAcid);
}
else
{
canvas.DrawCircle(xval, yval, (AMINORADIUS * percentDiff), NonPolarAminoAcid);
}
}
else
{
canvas.DrawCircle(xval, yval, (AMINORADIUS * percentDiff), InvalidAminoAcid);
}
angle += 100;
if (angle > 360)
{
angle -= 360;
}
lastAmino = item;
}
}
if (!string.IsNullOrWhiteSpace(lastAmino))
{
if (polarity)
{
canvas.DrawText(lastAmino.Substring(0, 1).ToString().ToUpper() + lastAmino.Substring(1, 2) + incr, xval - 7, yval + 4, PolarLetters);
}
else
{
canvas.DrawText(lastAmino.Substring(0, 1).ToString().ToUpper() + lastAmino.Substring(1, 2) + incr, xval - 7, yval + 4, NonPolarLetters);
}
}
}
private void RunAminoAnalysis(List <KeyValuePair <string, Point> > aminoList)
{
var items = aminoList;
bool prolineFound = false;
bool invalidAminoAcid = false;
var structErrors = new List <string>();
StructureAnalysis.Text = "The following issues were found: \n";
StructureAnalysis.TextColor = Color.Red;
foreach (var item in aminoList)
{
var countItem = item.Key.ToCharArray().ToList().Where(x => char.IsDigit(x)).Count();
if ((item.Key.Substring(0, 1).ToLower().Equals("p") || item.Key.Substring(0, item.Key.Length - countItem).ToLower().Equals("pro")) && !prolineFound)
{
prolineFound = true;
structErrors.Add("-Found one or more prolines present on the wheel");
continue;
}
if ((item.Key.Length - countItem) > 2 && !invalidAminoAcid)
{
if (!aminoClass.IsAminoAcid(item.Key.Substring(0, item.Key.Length - countItem)))
{
structErrors.Add("-Your helical structure contains one or more invalid amino acid(s).");
invalidAminoAcid = true;
continue;
}
}
if ((item.Key.Length - countItem) == 1 && !invalidAminoAcid)
{
if (!aminoClass.IsAminoAcid(null, item.Key.ToCharArray()[0]))
{
structErrors.Add("-Your helical structure contains one or more invalid amino acid(s).");
invalidAminoAcid = true;
continue;
}
}
List <KeyValuePair <string, Point> > templist = aminoList.Where(x => !x.Key.Equals(item.Key)).ToList();
var closeAminos = templist.Where(x => Math.Sqrt(Math.Pow((x.Value.X - item.Value.X), 4) + Math.Pow((x.Value.Y - item.Value.Y), 2)) <= 4);
List <KeyValuePair <string, string> > foundAminos = new List <KeyValuePair <string, string> >();
foreach (var item2 in closeAminos)
{
var countItem2 = item2.Key.ToCharArray().ToList().Where(x => char.IsDigit(x));
if (aminoClass.ContainsBulkyAminos(item.Key.Substring(0, item.Key.Length - countItem), item2.Key.Substring(0, item2.Key.Length - countItem2.Count())))
{
var text = $"-{item.Key} & {item2.Key} are bulky amino acids and shouldn't be very close to each other.";
KeyValuePair <string, string> keyPair1 = new KeyValuePair <string, string>(item.Key, item2.Key);
KeyValuePair <string, string> keyPair2 = new KeyValuePair <string, string>(item2.Key, item.Key);
if (!foundAminos.Contains(keyPair1))
{
structErrors.Add(text);
}
foundAminos.Add(keyPair1);
foundAminos.Add(keyPair2);
}
}
}
if (structErrors.Any())
{
foreach (var error in structErrors)
{
StructureAnalysis.Text += error + "\n";
}
}
else
{
StructureAnalysis.Text = "Your helical structure looks good !";
StructureAnalysis.TextColor = Color.ForestGreen;
}
StructureAnalysis.IsVisible = true;
Content = new ScrollView {
Content = MainView
};
//StructureAnalysis.HeightRequest = .40 * App.ScreenHeight;
}
public void HelicalWheelBuilderLetter(string aminoAcids, SKCanvas canvas)
{
// init. my variables
var aminoClass = new AminoAcids();
var listAminos = aminoAcids.ToCharArray().ToList();
float x = 0; float y = 0;
int angle = 270;
char lastChar = '0';
bool polarity = false;
float xModifier = 0;
float yModifier = 0;
float modIncrementer = 0;
float scaleModifier = 19;
int incr = 1;
var percentDiff = (App.ScreenHeight / ScaleFactor);
// iterate over the amino acids
foreach (var item in listAminos)
{
// if its a valid character
if (char.IsLetter(item))
{
// acheck to make sure to add the
if (lastChar != '0')
{
//draw line
if (incr < 18)
{
canvas.DrawLine(x, y, (float)((RADIUS * percentDiff) * Math.Cos(angle * Math.PI / 180F)), (float)((RADIUS * percentDiff) * Math.Sin(angle * Math.PI / 180F)), Line);
}
// check if polar or not then draw the circle accordingly
if (polarity)
{
canvas.DrawText(lastChar.ToString().ToUpper() + incr, x - 6, y + 4, PolarLetters);
}
else
{
canvas.DrawText(lastChar.ToString().ToUpper() + incr, x - 6, y + 4, NonPolarLetters);
}
incr += 1;
}
// determine the x & y coordinates using this formula
x = (float)((RADIUS * percentDiff) * Math.Cos(angle * Math.PI / 180F));
y = (float)((RADIUS * percentDiff) * Math.Sin(angle * Math.PI / 180F));
// add x & y coordinates to my global variable
HelicalStructure.Add(new KeyValuePair <string, Point>(item.ToString().ToUpper() + incr, new Point(x, y)));
if (incr % scaleModifier == 0)
{
modIncrementer += 1;
scaleModifier = scaleModifier + 18;
}
xModifier = x > 0? 13f * modIncrementer : -13f * modIncrementer;
yModifier = y > 0? 13f * modIncrementer : -13f * modIncrementer;
if (Math.Abs(x) < 5 && modIncrementer > 0)
{
yModifier = yModifier > 0 ? (yModifier - .5f) + (6 * modIncrementer) : (yModifier + .5f) - (6 * modIncrementer);
xModifier = 0;
}
x += xModifier;
y += yModifier;
if (aminoClass.IsAminoAcid(null, item))
{
if (polarity = aminoClass.IsPolar(null, item))
{
canvas.DrawCircle(x, y, (AMINORADIUS * percentDiff), PolarAminoAcid);
}
else
{
canvas.DrawCircle(x, y, (AMINORADIUS * percentDiff), NonPolarAminoAcid);
}
}
else
{
canvas.DrawCircle(x, y, (AMINORADIUS * percentDiff), InvalidAminoAcid);
}
angle += 100;
if (angle > 360)
{
angle -= 360;
}
lastChar = item;
}
}
if (char.IsLetter(lastChar))
{
if (polarity)
{
canvas.DrawText(lastChar.ToString().ToUpper() + incr, x - 6, y + 4, PolarLetters);
}
else
{
canvas.DrawText(lastChar.ToString().ToUpper() + incr, x - 6, y + 4, NonPolarLetters);
}
}
}
