private async Task <ModelProtocol> createAdvancedProtocolFrom(SnapshotProtocol snapshotProtocol)
{
var advancedProtocol = _protocolFactory.Create(ProtocolMode.Advanced).DowncastTo <AdvancedProtocol>();
advancedProtocol.RemoveAllSchemas();
advancedProtocol.TimeUnit = _dimensionRepository.Time.UnitOrDefault(snapshotProtocol.TimeUnit);
if (snapshotProtocol.Schemas == null)
{
return(advancedProtocol);
}
advancedProtocol.AddChildren(await _schemaMapper.MapToModels(snapshotProtocol.Schemas));
return(advancedProtocol);
}
private void ProtocolMessage(byte[] bytes)
{
try
{
do
{
IProtocol protocolServices = _protocolFactory.Create(bytes);
if (protocolServices == null)
{
//没有找到对应解析数据对象时，判断数据中校验位字符串数量，大于1的情况，对一个校验位后面的数据再次循环解析
//如果校验位字符串为0或者1,说明数据已经不正确了，退出本次解析任务
if (bytes.Count(r => r == ConstDefine.CheckUserId) > 1)
{
bytes = bytes.Skip(Array.IndexOf(bytes, ConstDefine.CheckUserId) + 1).ToArray();
}
else
{
break;
}
}
else
{
bytes = protocolServices.Receive(bytes);
}
} while (bytes.Length > 0);
}
catch (Exception exception)
{
_logger.LogError(exception.InnerException?.Message ?? exception.Message);
}
}
public void CalculateBioavailabilityFor(Simulation simulation, string compoundName)
{
var individualSimulation = simulation as IndividualSimulation;
if (individualSimulation == null)
{
return;
}
var compound = simulation.Compounds.FindByName(compoundName);
//BA calculated with a Simple IV with 15 min infusion
var simpleIvProtocol = _protocolFactory.Create(ProtocolMode.Simple, ApplicationTypes.Intravenous)
.WithName("Simple IV for Bioavailability")
.DowncastTo <SimpleProtocol>();
simpleIvProtocol.Parameter(Constants.Parameters.INFUSION_TIME).Value = 15;
var simulationSingleDosingItem = singleDosingItem(simulation, compound);
simpleIvProtocol.Dose.DisplayUnit = simulationSingleDosingItem.Dose.DisplayUnit;
simpleIvProtocol.Dose.Value = simulationSingleDosingItem.Dose.Value;
simpleIvProtocol.StartTime.Value = simulationSingleDosingItem.StartTime.Value;
var ivSimulation = _globalPKAnalysisRunner.RunForBioavailability(simpleIvProtocol, individualSimulation, compound);
var venousBloodCurve = ivSimulation.DataRepository.VenousBloodColumn(compoundName);
var pkVenousBlood = _pkAnalysisTask.CalculateFor(ivSimulation, venousBloodCurve).PKAnalysis;
individualSimulation.CompoundPKFor(compoundName).AucIV = pkParameterValue(pkVenousBlood, Constants.PKParameters.AUC_inf);
}
public ICache <Species, IParameter> VSSPhysChemFor(Compound compound)
{
var cache = new Cache <Species, IParameter>();
var protocol = _protocolFactory.Create(ProtocolMode.Simple);
_speciesRepository.All().Each(species =>
{
var defaultIndividual = _defaultIndividualRetriever.DefaultIndividualFor(species);
var simulation = _simulationFactory.CreateForVSS(protocol, defaultIndividual, compound);
cache[species] = VSSPhysChemFor(simulation, compound.Name);
});
return(cache);
}
void IConnector.Bind(IReactor dispatcher, IProtocolFactory factory, IPEndPoint localEP, int bufferSize)
{
_udpClient = new UdpClient(localEP);
_udpClient.Client.ReceiveBufferSize = bufferSize;
var protocol = factory.Create();
var connection = new DatagramConnection(dispatcher, protocol, _udpClient);
connection.Start(true);
protocol.Bind(connection);
protocol.Connected();
}
private void ClientAcceptCallback(IAsyncResult ar)
{
var tcpClient = ((TcpListener)ar.AsyncState).EndAcceptTcpClient(ar);
var protocol = _factory.Create();
var connection = new StreamConnection(_dispatcher, protocol, tcpClient, _bufferSize);
connection.Start(true);
protocol.Bind(connection);
protocol.Connected();
this.StartAccept();
}
void IConnector.Bind(IReactor dispatcher, IProtocolFactory factory, IPEndPoint localEP, int bufferSize)
{
_udpClient = new UdpClient(localEP);
_udpClient.Client.ReceiveBufferSize = bufferSize;
var protocol = factory.Create();
var connection = new DatagramConnection(dispatcher, protocol, _udpClient);
connection.Start(true);
protocol.Bind(connection);
protocol.Connected();
}
private void PeerConnectCallback(IAsyncResult ar)
{
var tcpClient = ((TcpClient)ar.AsyncState);
tcpClient.EndConnect(ar);
var protocol = _factory.Create();
var connection = new StreamConnection(_dispatcher, protocol, tcpClient, _bufferSize);
protocol.Bind(connection);
protocol.Connected();
connection.Start(false);
}
protected override void Context()
{
_context = A.Fake <IExecutionContext>();
_protocolUpdater = A.Fake <IProtocolUpdater>();
_protocolFactory = A.Fake <IProtocolFactory>();
_project = A.Fake <PKSimProject>();
_oldProtocol = A.Fake <Protocol>();
_oldProtocolMode = ProtocolMode.Simple;
_newProtocolMode = ProtocolMode.Advanced;
A.CallTo(() => _context.CurrentProject).Returns(_project);
A.CallTo(() => _context.Resolve <IProtocolUpdater>()).Returns(_protocolUpdater);
A.CallTo(() => _context.Resolve <IProtocolFactory>()).Returns(_protocolFactory);
_newProtocol = A.Fake <Protocol>();
A.CallTo(() => _protocolFactory.Create(_newProtocolMode)).Returns(_newProtocol);
sut = new SetProtocolModeCommand(_oldProtocol, _oldProtocolMode, _newProtocolMode, _context);
}
protected override void Context()
{
_view = A.Fake <ICreateProtocolView>();
_propertiesMapper = A.Fake <IBuildingBlockPropertiesMapper>();
_simpleProtocolPresenter = A.Fake <ISimpleProtocolPresenter>();
_protocolFactory = A.Fake <IProtocolFactory>();
_propertiesDTOMapper = A.Fake <IProtocolToProtocolPropertiesDTOMapper>();
_advancedProtocolPresenter = A.Fake <IAdvancedProtocolPresenter>();
_protocolUpdater = A.Fake <IProtocolUpdater>();
_protocolChartPresenter = A.Fake <IProtocolChartPresenter>();
_subPresenterManager = A.Fake <ISubPresenterItemManager <IProtocolItemPresenter> >();
_dialogCreator = A.Fake <IDialogCreator>();
A.CallTo(() => _protocolFactory.Create(ProtocolMode.Simple)).Returns(new SimpleProtocol());
A.CallTo(() => _subPresenterManager.AllSubPresenters).Returns(new IProtocolItemPresenter[] { _simpleProtocolPresenter, _advancedProtocolPresenter });
sut = new CreateProtocolPresenter(_view, _subPresenterManager, _propertiesMapper,
_protocolChartPresenter, _protocolFactory, _protocolUpdater, _propertiesDTOMapper, _dialogCreator);
sut.Initialize();
}
public Protocol MapFrom(ApplicationProtocol batchProtocol)
{
var applicationType = ApplicationTypes.ByName(batchProtocol.ApplicationType);
var dosingIntervalId = EnumHelper.ParseValue <DosingIntervalId>(batchProtocol.DosingInterval);
var simpleProtocol = _protocolFactory.Create(ProtocolMode.Simple, applicationType).DowncastTo <SimpleProtocol>();
simpleProtocol.Name = batchProtocol.Name ?? "Protocol";
simpleProtocol.EndTimeParameter.Value = batchProtocol.EndTime;
simpleProtocol.Dose.DisplayUnit = simpleProtocol.Dose.Dimension.Unit(batchProtocol.DoseUnit);
simpleProtocol.Dose.Value = simpleProtocol.Dose.Dimension.UnitValueToBaseUnitValue(simpleProtocol.Dose.DisplayUnit, batchProtocol.Dose);
simpleProtocol.DosingInterval = DosingIntervals.ById(dosingIntervalId);
_logger.AddDebug($"Application Type = {applicationType.Name}");
_logger.AddDebug($"Dosing Interval = {simpleProtocol.DosingInterval.DisplayName}");
_logger.AddDebug($"Application Dose = {simpleProtocol.Dose.Value} [{simpleProtocol.Dose.DisplayUnit}]");
_logger.AddDebug($"Application End Time = {simpleProtocol.EndTime}");
return(simpleProtocol);
}
public void DoSomething()
{
ProtocolBaseClass protocol = _factory.Create();
