private void PictureBox1_MouseUp(object sender, MouseEventArgs e) { using (var bmp = new Bitmap(PictureBox1.Image.Width, PictureBox1.Image.Height)) { PictureBox1.DrawToBitmap(bmp, PictureBox1.ClientRectangle); var color = bmp.GetPixel(e.X, e.Y); var red = color.R; var green = color.G; var blue = color.B; MessageBox.Show(Convert.ToString(red + " " + green + " " + blue + "")); } }