public float?EstimateStartTimeFrom(PKCalculationOptions pkCalculationOptions)
{
double?estimatedStartTime()
{
if (StartTime != null)
{
return(StartTime + StartTimeOffset.GetValueOrDefault(0));
}
var applicationIndex = StartApplicationIndex.GetValueOrDefault(-1);
if (applicationIndex < 0)
{
return(null);
}
var dosingInterval = pkCalculationOptions.DosingIntervalAt(applicationIndex);
if (dosingInterval?.StartValue == null)
{
return(null);
}
return(dosingInterval.StartValue + StartTimeOffset.GetValueOrDefault(0));
}
return(toNullableFloat(estimatedStartTime()));
}
public float?EstimateEndTimeFrom(PKCalculationOptions pkCalculationOptions)
{
double?estimatedEndTime()
{
if (EndTime != null)
{
return(EndTime + EndTimeOffset.GetValueOrDefault(0));
}
var applicationIndex = EndApplicationIndex.GetValueOrDefault(-1);
if (applicationIndex < 0)
{
return(null);
}
var dosingInterval = pkCalculationOptions.DosingIntervalAt(applicationIndex);
if (dosingInterval?.StartValue == null)
{
return(null);
}
//We use the start value here as we are not interested in the time after the application
return(dosingInterval.StartValue + EndTimeOffset.GetValueOrDefault(0));
}
return(toNullableFloat(estimatedEndTime()));
}
public double?EstimateDrugMassPerBodyWeight(PKCalculationOptions pkCalculationOptions)
{
// It can be quite complicated to estimate the total drug mass between two intervals
// If a start time and end time is provided or any time offset, we cannot calculate for sure and we'll return NULL
// if a start application and an end infusion index is provided, we'll sum up the interval between those two application
// if a start application is provided, we'll sum up the drug mass starting at this application until the end
// if an end application is provided, we'll sum up the drug mass from the start until the application
if (StartTime.HasValue || EndTime.HasValue || EndTimeOffset.HasValue || StartTimeOffset.HasValue)
{
return(null);
}
//no intervals defined
if (!StartApplicationIndex.HasValue && !EndApplicationIndex.HasValue)
{
return(pkCalculationOptions.TotalDrugMassPerBodyWeight);
}
var startApplicationIndex = StartApplicationIndex.GetValueOrDefault(0);
var endApplicationIndex = EndApplicationIndex.GetValueOrDefault(pkCalculationOptions.DosingIntervals.Count);
// invalid intervals
if (startApplicationIndex >= endApplicationIndex)
{
return(null);
}
double drugMassPerBodyWeight = 0;
for (int applicationIndex = startApplicationIndex; applicationIndex < endApplicationIndex; applicationIndex++)
{
//wrong indexes
var interval = pkCalculationOptions.DosingIntervalAt(applicationIndex);
if (interval == null)
{
return(null);
}
drugMassPerBodyWeight += interval.DrugMassPerBodyWeight.GetValueOrDefault(0);
}
return(drugMassPerBodyWeight);
}