protected override void Context()
{
base.Context();
_individualCharacteristics = new IndividualCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.ICRP,
Age = new Parameter
{
Value = 30,
Unit = "year(s)",
},
Weight = new Parameter
{
Value = 75,
Unit = "kg",
},
Height = new Parameter
{
Value = 175,
Unit = "cm",
},
Gender = CoreConstants.Gender.Male
};
}
protected override void Context()
{
base.Context();
_individualCharacteristics = new IndividualCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.ICRP,
Age = new Parameter
{
Value = 30,
Unit = "year(s)",
},
Weight = new Parameter
{
Value = 75,
Unit = "kg",
},
Height = new Parameter
{
Value = 175,
Unit = "cm",
},
Gender = CoreConstants.Gender.MALE,
DiseaseState = CoreConstants.DiseaseStates.CKD
};
_individualCharacteristics.AddDiseaseStateParameter(new Parameter {
Name = TARGET_GFR, Value = 0.005, Unit = GFR_UNIT
});
}
protected override void Context()
{
base.Context();
_individualCharacteristics = new IndividualCharacteristics
{
Species = CoreConstants.Species.HUMAN,
Population = CoreConstants.Population.ICRP,
};
}
public CreateIndividualResults CreateIndividual(IndividualCharacteristics individualCharacteristics)
{
var originData = originDataFrom(individualCharacteristics);
var moleculeOntogenies = individualCharacteristics.MoleculeOntogenies;
var individual = _individualFactory.CreateAndOptimizeFor(originData, individualCharacteristics.Seed);
var individualProperties = _individualValuesMapper.MapFrom(individual);
var allIndividualParameters = individualProperties.ParameterValues;
var ontogenyParameters = _ontogenyFactorsRetriever.FactorsFor(originData, moleculeOntogenies).Select(x => new ParameterValueWithUnit(x));
var allDistributedParameterCache = _containerTask.CacheAllChildren <IDistributedParameter>(individual);
var allIndividualParametersCache = _containerTask.CacheAllChildren <IParameter>(individual);
var distributedParameters = new Cache <string, ParameterValueWithUnit>(x => x.ParameterPath);
var derivedParameters = new List <ParameterValueWithUnit>();
//Add Age and Height parameter that is not distributed at the moment
if (originData.Population.IsAgeDependent)
{
distributedParameters.Add(parameterValueFrom(individual.Organism.Parameter(CoreConstants.Parameters.AGE)));
distributedParameters.Add(parameterValueFrom(individual.Organism.Parameter(Constants.Parameters.GESTATIONAL_AGE)));
}
if (originData.Population.IsHeightDependent)
{
distributedParameters.Add(parameterValueFrom(individual.Organism.Parameter(CoreConstants.Parameters.HEIGHT)));
}
distributedParameters.Add(parameterValueFrom(individual.Organism.Parameter(CoreConstants.Parameters.ONTOGENY_FACTOR_AGP)));
distributedParameters.Add(parameterValueFrom(individual.Organism.Parameter(CoreConstants.Parameters.ONTOGENY_FACTOR_ALBUMIN)));
foreach (var individualParameter in allIndividualParameters)
{
var parameter = allIndividualParametersCache[individualParameter.ParameterPath];
if (parameter == null)
{
continue;
}
var parameterValue = new ParameterValueWithUnit(individualParameter, parameter?.BaseUnitName());
if (allDistributedParameterCache.Contains(individualParameter.ParameterPath))
{
distributedParameters.Add(parameterValue);
}
//Do not add parameters that were added specifically
else if (!distributedParameters.Contains(individualParameter.ParameterPath))
{
derivedParameters.Add(parameterValue);
}
}
//add Ontogeny parameters
distributedParameters.AddRange(ontogenyParameters);
return(new CreateIndividualResults(distributedParameters.ToArray(), derivedParameters.ToArray(), individual.Seed));
}
public DistributedParameterValueWithUnit[] DistributionsFor(IndividualCharacteristics individualCharacteristics)
{
var originData = originDataFrom(individualCharacteristics);
var moleculeOntogenies = individualCharacteristics.MoleculeOntogenies;
var individual = _individualFactory.CreateAndOptimizeFor(originData, individualCharacteristics.Seed);
var distributedParameters = individual.GetAllChildren <IDistributedParameter>().Select(distributedParameterValueFrom).ToList();
//Ontogeny factors have no units
distributedParameters.AddRange(_ontogenyFactorsRetriever.DistributionFactorsFor(originData, moleculeOntogenies)
.Select(x => new DistributedParameterValueWithUnit(x, "")));
return(distributedParameters.ToArray());
}