public PedigreeGenerator(int Width, int Height, Patient proband)
{
height = Height;
width = Width;
//pedigreeControl1 = new PedigreeControl();
pedigreeControl1 = new PedigreeControl(false);
pedigreeLegend1 = new PedigreeLegend();
pedigreeComment1 = new PedigreeComment();
pedigreeTitleBlock1 = new PedigreeTitleBlock();
sysDefaultAnnotations = new PedigreeAnnotationList("-1");
sysDefaultAnnotations.BackgroundListLoad();
pedigreeSettingsForm1 = new PedigreeSettingsForm(sysDefaultAnnotations);
if (proband != null)
{
if (proband.guiPreferences.Count == 0)
{
GUIPreference gp = new GUIPreference();
gp.BackgroundLoadWork();
proband.guiPreferences.Add(gp);
}
}
}
/**************************************************************************************************/
private GUIPreference getBestFitExistingGuiPreference(bool exactMatchOnly)
{
List <GUIPreference> localList = proband.guiPreferences.ConvertAll(x => (GUIPreference)x);
String parentFormText = "";
if (localList.Count == 0)
{
GUIPreference guiPreference;
//String parentFormText = (this.ParentForm != null) ? this.ParentForm.Text : "";
guiPreference = new GUIPreference(proband, DateTime.Now, "", parentFormText, width, height, true);
HraModelChangedEventArgs args = new HraModelChangedEventArgs(null);
args.Persist = true;
proband.guiPreferences.AddToList(guiPreference, args);
return(guiPreference);
}
else
{
GUIPreference guiPreference = null;
foreach (GUIPreference gp in localList)
{
//if (guiPreference == null)
guiPreference = gp;
}
return(guiPreference);
}
}
/**************************************************************************************************/
public MetaData()
{
Diseases = new DiseaseList();
GeneticTests = new GeneticTestList();
Users = new UserList();
UserGroups = new UserGroupList();
OrderTypes = new OrderTypesList();
Mutations = new MutationList();
SystemWideDefaultPedigreePrefs = new GUIPreference();
CurrentUserDefaultPedigreePrefs = new GUIPreference();
ApptProviders = new ApptProviderList();
KbVariants = new VariantsFromKB();
BrOvCdsRecs = new AllBrOvCdsRecs();
Globals = new GlobalSettings();
}
internal void SetVariantLabel(string label, GUIPreference currentGuiPrefs)
{
if (variantLabel.InvokeRequired)
{
SetVariantLabelCallback aoc = SetVariantLabel;
object[] args = new object[1];
args[0] = label;
args[1] = currentGuiPrefs;
this.Invoke(aoc, args);
}
else
{
variantLabel.Text = label;
int width = this.ComputeOptimalWidth();
int height = this.ComputeOptimalHeight();
if (currentGuiPrefs != null)
{
currentGuiPrefs.GUIPreference_TitleWidth = width;
currentGuiPrefs.GUIPreference_TitleHeight = height;
}
}
}
private void GeneratePedigree()
{
int MaxWidth = width;
int MaxHeight = height;
bool new_gui_pref = true;
if (proband.guiPreferences.Count == 0)
{
new_gui_pref = true;
}
pedigreeTitleBlock1.NameText = proband.name;
pedigreeTitleBlock1.MRN = proband.unitnum;
pedigreeTitleBlock1.DOB = proband.dob;
pedigreeComment1.proband = proband;
pedigreeComment1.Text = proband.family_comment;
proband.FHx.SetIDsFromRelationships();
pedigreeControl1.ForceLoadFamily(proband.FHx);
currentPrefs = getBestFitExistingGuiPreference(false);
pedigreeControl1.currentPrefs = currentPrefs;
if (string.IsNullOrEmpty(proband.family_comment))
{
pedigreeComment1.Visible = false;
}
if (pedigreeControl1.currentPrefs.GUIPreference_width != 0 && pedigreeControl1.currentPrefs.GUIPreference_height != 0)
{
//pedigreeControl1.Width = pedigreeControl1.currentPrefs.GUIPreference_width;
//pedigreeControl1.Height = pedigreeControl1.currentPrefs.GUIPreference_height;
//width = pedigreeControl1.currentPrefs.GUIPreference_width;
//height = pedigreeControl1.currentPrefs.GUIPreference_height;
if (!new_gui_pref)
{
pedigreeControl1.Width = pedigreeControl1.currentPrefs.GUIPreference_width;
pedigreeControl1.Height = pedigreeControl1.currentPrefs.GUIPreference_height;
width = pedigreeControl1.currentPrefs.GUIPreference_width;
height = pedigreeControl1.currentPrefs.GUIPreference_height;
}
else
{
pedigreeControl1.Width = width;
pedigreeControl1.Height = height;
}
float x = pedigreeControl1.model.parameters.scale = ((float)pedigreeControl1.currentPrefs.GUIPreference_zoomValue) / 100.0f;
pedigreeControl1.model.parameters.scale = 0.65f * x;
//pedigreeControl1.model.parameters.scale = (float)height / (float)pedigreeControl1.currentPrefs.GUIPreference_height * x;
//pedigreeControl1.model.parameters.scale = (float)width / (float)pedigreeControl1.currentPrefs.GUIPreference_width * x;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
foreach (PedigreeIndividual pi in pedigreeControl1.model.individuals)
{
foreach (ClincalObservation co in pi.HraPerson.PMH.Observations)
{
pedigreeLegend1.AddSingleObservation(co, false);
pedigreeLegend1.Visible = true;
}
}
}
if (new_gui_pref)
{
int minx = int.MaxValue;
int maxx = int.MinValue;
int miny = int.MaxValue;
int maxy = int.MinValue;
foreach (PedigreeIndividual pi in pedigreeControl1.model.individuals)
{
foreach (ClincalObservation co in pi.HraPerson.PMH.Observations)
{
pedigreeLegend1.AddSingleObservation(co, false);
pedigreeLegend1.Visible = true;
}
if (pi.HraPerson.x_norm == int.MinValue)
{
pi.HraPerson.x_norm = (int)(pi.point.x - (pedigreeControl1.model.displayXMax / 2));
}
if (pi.HraPerson.y_norm == int.MinValue)
{
pi.HraPerson.y_norm = (int)(pi.point.y - (pedigreeControl1.model.displayYMax / 2));
}
if (pi.HraPerson.x_norm < minx)
{
minx = pi.HraPerson.x_norm;
}
if (pi.HraPerson.x_norm > maxx)
{
maxx = pi.HraPerson.x_norm;
}
if (pi.HraPerson.y_norm < miny)
{
miny = pi.HraPerson.y_norm;
}
if (pi.HraPerson.y_norm > maxx)
{
maxy = pi.HraPerson.y_norm;
}
}
maxx += 60;
minx -= 60;
float zoom = (float)((double)width / (double)(maxx - minx));
if (zoom < 1.0f)
{
pedigreeControl1.model.parameters.scale = zoom;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
}
else
{
pedigreeControl1.model.parameters.scale = 1;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
}
if (pedigreeControl1.model.parameters.scale > 0 && pedigreeControl1.model.parameters.scale < 2.0f)
{
pedigreeControl1.currentPrefs.GUIPreference_zoomValue = (int)(150.0f * pedigreeControl1.model.parameters.scale);
}
pedigreeControl1.controller.SetMode("SELF_ORGANIZING");
int counter = 0;
while (pedigreeControl1.model.converged == false && counter < 200) //for (int i = 0; i < 100; i++)
{
pedigreeControl1.controller.IncrementLayout();
counter++;
}
pedigreeControl1.CenterIndividuals();
}
ApplyPrefs();
if (new_gui_pref)
{
//pedigreeLegend1.Location = new Point(pedigreeTitleBlock1.Location.X + pedigreeTitleBlock1.Width + 10, pedigreeTitleBlock1.Location.Y);
}
if (showBrcaScores)
{
pedigreeSettingsForm1.showBrcaScores();
}
else
{
pedigreeSettingsForm1.hideBrcaScores();
}
if (showMmrScores)
{
pedigreeSettingsForm1.showMmrScores();
}
else
{
pedigreeSettingsForm1.hideMmrScores();
}
pedigreeControl1.model.parameters.annotation_areas = pedigreeSettingsForm1.annotation_areas;
pedigreeControl1.model.FamilialVariants = FamilialVariants;
image = new Bitmap(width, height);
Graphics g = Graphics.FromImage(image);
pedigreeControl1.DrawFromView(g, width, height);
pedigreeTitleBlock1.DrawToBitmapWithBorder(image, new Rectangle(pedigreeTitleBlock1.Location, pedigreeTitleBlock1.Size));
if (string.IsNullOrEmpty(proband.Patient_Comment) == false && pedigreeComment1.Visible)
{
pedigreeComment1.DrawToBitmapWithBorder(image, new Rectangle(pedigreeComment1.Location, pedigreeComment1.Size));
}
if (pedigreeLegend1.Visible)
{
pedigreeLegend1.DrawToBitmapWithBorder(image, new Rectangle(pedigreeLegend1.Location, pedigreeLegend1.Size));
}
float MaxRatio = MaxWidth / (float)MaxHeight;
float ImgRatio = image.Width / (float)image.Height;
if (image.Width > MaxWidth)
{
image = new Bitmap(image, new Size(MaxWidth, (int)Math.Round(MaxWidth /
ImgRatio, 0)));
}
if (image.Height > MaxHeight)
{
image = new Bitmap(image, new Size((int)Math.Round(MaxWidth * ImgRatio,
0), MaxHeight));
}
}
private void GeneratePedigree()
{
pedigreeTitleBlock1.NameText = proband.name;
pedigreeTitleBlock1.MRN = proband.unitnum;
pedigreeTitleBlock1.DOB = proband.dob;
pedigreeComment1.proband = proband;
pedigreeComment1.Text = proband.family_comment;
proband.FHx.SetIDsFromRelationships();
pedigreeControl1.ForceLoadFamily(proband.FHx);
currentPrefs = getBestFitExistingGuiPreference(false);
pedigreeControl1.currentPrefs = currentPrefs;
ShowComments();
if (pedigreeControl1.currentPrefs.GUIPreference_width != 0 && pedigreeControl1.currentPrefs.GUIPreference_height != 0)
{
pedigreeControl1.Width = width;
pedigreeControl1.Height = height;
float x = pedigreeControl1.model.parameters.scale = ((float)pedigreeControl1.currentPrefs.GUIPreference_zoomValue) / 100.0f;
pedigreeControl1.model.parameters.scale = 0.65f * x;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
}
AddObservations();
pedigreeControl1.model.individuals.ForEach(SetNorms);
var maxx = pedigreeControl1.model.individuals.Max(pi => pi.HraPerson.x_norm);
var minx = pedigreeControl1.model.individuals.Min(pi => pi.HraPerson.x_norm);
var maxy = pedigreeControl1.model.individuals.Max(pi => pi.HraPerson.y_norm);
var miny = pedigreeControl1.model.individuals.Min(pi => pi.HraPerson.y_norm);
maxx += 60;
minx -= 60;
maxy += 80;
miny -= 20;
int pedigreeHeight = maxy - miny;
this.height = pedigreeHeight;
//TODO not sure if this is optimal - may want to determine if scale is limited by x or y and scale accordingly
float zoom = (float)((double)width / (double)(maxx - minx));
if (zoom < 1.0f)
{
pedigreeControl1.model.parameters.scale = zoom;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
}
else
{
pedigreeControl1.model.parameters.scale = 1;
pedigreeControl1.model.parameters.hOffset = (int)(((width / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayXMax / 2));
pedigreeControl1.model.parameters.vOffset = (int)(((height / 2) / pedigreeControl1.model.parameters.scale) - (float)(pedigreeControl1.model.displayYMax / 2));
}
if (pedigreeControl1.model.parameters.scale > 0 && pedigreeControl1.model.parameters.scale < 2.0f)
{
pedigreeControl1.currentPrefs.GUIPreference_zoomValue = (int)(150.0f * pedigreeControl1.model.parameters.scale);
}
pedigreeControl1.controller.SetMode("SELF_ORGANIZING");
int counter = 0;
while (pedigreeControl1.model.converged == false && counter < 200) //for (int i = 0; i < 100; i++)
{
pedigreeControl1.controller.IncrementLayout();
counter++;
}
pedigreeControl1.CenterIndividuals();
ApplyPrefs();
ShowBrcaScores();
ShowMmrScores();
pedigreeControl1.model.parameters.annotation_areas = pedigreeSettingsForm1.annotation_areas;
pedigreeControl1.model.FamilialVariants = FamilialVariants;
Rectangle legendLayout;
Rectangle commentBoxLayout;
Rectangle titleBlockLayout;
Rectangle pedigreeRegionLayout;
Rectangle backdropLayout;
int totalHeight;
ComputePedigreeLayout(width, height,
out legendLayout,
out commentBoxLayout,
out titleBlockLayout,
out pedigreeRegionLayout,
out backdropLayout,
out totalHeight);
image = new Bitmap(width, totalHeight);
Control canvasControl = new Control
{
BackColor = Color.White,
Width = backdropLayout.Width,
Height = backdropLayout.Height
};
canvasControl.DrawToBitmap(image, backdropLayout);
pedigreeControl1.DrawToBitmap(image, pedigreeRegionLayout);
pedigreeTitleBlock1.DrawToBitmapWithBorder(image, titleBlockLayout);
if (string.IsNullOrEmpty(proband.Patient_Comment) == false && pedigreeComment1.Visible)
{
pedigreeComment1.DrawToBitmapWithBorder(image, commentBoxLayout);
}
if (pedigreeLegend1.Visible)
{
pedigreeLegend1.DrawToBitmapWithBorder(image, legendLayout);
}
}
