private FormulationSelection formulationSelectionFrom(FormulationMapping formulationMapping, PKSimProject project)
{
var formulation = project.BuildingBlockById(formulationMapping.TemplateFormulationId) ?? formulationMapping.Formulation;
return(new FormulationSelection {
Name = formulation.Name, Key = formulationMapping.FormulationKey
});
}
protected override void Context()
{
_simulation = new IndividualSimulation
{
Properties = new SimulationProperties(),
SimulationSettings = new SimulationSettings(),
ModelConfiguration = new ModelConfiguration()
};
_individual = new Individual().WithName("MyIndividual");
_speciesPopulation = new SpeciesPopulation();
_individual.OriginData = new OriginData {
SpeciesPopulation = _speciesPopulation
};
_compound = A.Fake <Compound>().WithName("MyCompound");
_protocol = A.Fake <SimpleProtocol>().WithName("MyProtocol");
_formulation = A.Fake <Formulation>().WithName("Formulation");
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Individual", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Compound", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Protocol", PKSimBuildingBlockType.Protocol)
{
BuildingBlock = _protocol
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Formulation", PKSimBuildingBlockType.Formulation)
{
BuildingBlock = _formulation
});
_protocolToProtocolSchemaItemMapper = A.Fake <IProtocolToSchemaItemsMapper>();
sut = new SimulationConfigurationValidator(_protocolToProtocolSchemaItemMapper);
_speciesPopulation.IsHeightDependent = false;
_schemaItem = A.Fake <SchemaItem>();
_doseUnit = A.Fake <Unit>();
_schemaItem.Dose.DisplayUnit = _doseUnit;
_protocolProperties = new ProtocolProperties();
_formulationMapping = new FormulationMapping {
FormulationKey = "F1", Formulation = _formulation
};
_simulation.Properties.AddCompoundProperties(new CompoundProperties
{
Compound = _compound,
ProtocolProperties = _protocolProperties
});
A.CallTo(() => _protocolToProtocolSchemaItemMapper.MapFrom(_protocol)).Returns(new [] { _schemaItem });
}
private void updateFormulationMapping(ProtocolProperties protocolProperties, FormulationSelection[] snapshotProtocolFormulations, PKSimProject project)
{
snapshotProtocolFormulations?.Each(x =>
{
var formulation = project.BuildingBlockByName <Model.Formulation>(x.Name);
var formulationMapping = new FormulationMapping
{
Formulation = formulation,
FormulationKey = x.Key,
TemplateFormulationId = formulation.Id
};
protocolProperties.AddFormulationMapping(formulationMapping);
});
}
private Formulation retrieveFormulation(Simulation simulation, FormulationMapping formulationMapping, Func <UsedBuildingBlock, Formulation> formulationRetriever)
{
if (!isValid(formulationMapping))
{
return(null);
}
var templateFormulation = _buildingBlockRepository.ById <Formulation>(formulationMapping.TemplateFormulationId);
var usedBuildingBlock = simulation.UsedBuildingBlockByTemplateId(formulationMapping.TemplateFormulationId);
//this forumation was not used in the simulation yet, return the template
if (usedBuildingBlock == null)
{
return(templateFormulation);
}
//formulation was used in the simulation.
var formulation = formulationRetriever(usedBuildingBlock);
return(formulation ?? templateFormulation);
}
protected override void Context()
{
base.Context();
_formulation = new Formulation();
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_formulationUsedInSimulation = new Formulation();
_usedBuildingBlockFormulation = new UsedBuildingBlock("template", PKSimBuildingBlockType.Formulation)
{
BuildingBlock = _formulationUsedInSimulation
};
var compoundProperties = new CompoundProperties();
var formulationMapping = new FormulationMapping {
Formulation = _formulation
};
compoundProperties.ProtocolProperties.AddFormulationMapping(formulationMapping);
_simulation.Properties.AddCompoundProperties(compoundProperties);
A.CallTo(() => _buildingBlockMapper.MapFrom(_formulation, null)).Returns(_usedBuildingBlockFormulation);
}
protected override void Context()
{
base.Context();
_emptyFormulation = string.Empty;
_formulationKey1 = "Tralal";
_formulationKey2 = "toto";
_formulation1.AddRoute(ApplicationTypes.Intravenous.Route);
_formulation2.AddRoute(ApplicationTypes.Oral.Route);
var formulationMapping1 = new FormulationMapping();
var formulationMapping2 = new FormulationMapping();
A.CallTo(() => _protocol.UsedFormulationKeys).Returns(new[] { _emptyFormulation, _formulationKey1, _formulationKey2 });
A.CallTo(() => _protocolProperties.MappingWith(_formulationKey1)).Returns(formulationMapping1);
A.CallTo(() => _protocolProperties.MappingWith(_formulationKey2)).Returns(formulationMapping2);
A.CallTo(() => _protocol.ApplicationTypeUsing(_formulationKey1)).Returns(ApplicationTypes.Intravenous);
A.CallTo(() => _protocol.ApplicationTypeUsing(_formulationKey2)).Returns(ApplicationTypes.Oral);
A.CallTo(() => _formulationFromMappingRetriever.TemplateFormulationUsedBy(_simulation, formulationMapping1)).Returns(_formulation1);
A.CallTo(() => _formulationFromMappingRetriever.TemplateFormulationUsedBy(_simulation, formulationMapping2)).Returns(null);
_formulation2.AddRoute(ApplicationTypes.Oral.Route);
A.CallTo(() => _view.BindTo(A <IEnumerable <FormulationMappingDTO> > ._))
.Invokes(x => _formMappingDtoList = x.GetArgument <IEnumerable <FormulationMappingDTO> >(0).ToList());
}
private bool isValid(FormulationMapping formulationMapping)
{
return(formulationMapping != null && !formulationMapping.TemplateFormulationId.IsNullOrEmpty());
}
public Formulation TemplateFormulationUsedBy(Simulation simulation, FormulationMapping formulationMapping)
{
return(retrieveFormulation(simulation, formulationMapping, _buildingBlockInSimulationManager.TemplateBuildingBlockUsedBy <Formulation>));
}
public Formulation FormulationUsedBy(Simulation simulation, FormulationMapping formulationMapping)
{
return(retrieveFormulation(simulation, formulationMapping, b => b.BuildingBlock as Formulation));
}
protected override void Because()
{
_result = sut.MapFrom(_formulationMappingDTO, _simulation);
}
