public static ComparisonResults Compare(Rna candidate, Rna vaccine, Rna virus)
{
var codonEqualCount = 0;
var codonIndex = 0;
var incorrect = new Dictionary <string, int>();
foreach (var candidateCodon in candidate.Codons)
{
var vaccineCodon = vaccine.Codons[codonIndex].Nucleotides;
if (candidateCodon.Nucleotides == vaccineCodon)
{
codonEqualCount++;
}
else
{
if (incorrect.ContainsKey(candidateCodon.Nucleotides))
{
incorrect[candidateCodon.Nucleotides] += 1;
}
else
{
incorrect.Add(candidateCodon.Nucleotides, 1);
}
}
codonIndex++;
}
var candidateNucleotides = candidate.Codons.SelectMany(x => x.Nucleotides).ToList();
var nucleotideEqualCount = GetCorrectNucleotides(candidate, vaccine, candidateNucleotides);
return(new ComparisonResults(codonEqualCount, candidate.Codons.Count, nucleotideEqualCount, candidateNucleotides.Count(), incorrect, candidate, vaccine, virus));
}
public ComparisonResults(int matchingCodons, int totalCodons, int matchingNucleotides, int totalNucleotides, Dictionary <string, int> nonMatchingCodon, Rna candidate, Rna vaccine, Rna virus)
{
MatchingCodons = matchingCodons;
TotalCodons = totalCodons;
MatchingNucleotides = matchingNucleotides;
TotalNucleotides = totalNucleotides;
NonmatchingCodons = nonMatchingCodon;
Candidate = candidate;
Vaccine = vaccine;
Virus = virus;
}
private static int GetCorrectNucleotides(Rna candidate, Rna vaccine, List <char> candidateNucleotides)
{
var vaccineNucleotides = vaccine.Codons.SelectMany(x => x.Nucleotides).ToList();
var nucleotideIndex = 0;
var nucleotideEqualCount = 0;
foreach (var nucleotide in candidateNucleotides)
{
if (nucleotide == vaccineNucleotides[nucleotideIndex])
{
nucleotideEqualCount++;
}
nucleotideIndex++;
}
return(nucleotideEqualCount);
}
public static Rna GetVaccineCandidate()
{
var vaccineCandidate = new Rna();
foreach (var virusCodon in Protein.VirusProtein.Codons)
{
if (FullReplacements.ContainsKey(virusCodon.Nucleotides))
{
vaccineCandidate.Codons.Add(new Codon(virusCodon.Index, FullReplacements[virusCodon.Nucleotides]));
}
else
{
vaccineCandidate.Codons.Add(virusCodon);
}
}
return(vaccineCandidate);
}
