private (int Start, string RefAllele, string AltAllele) LeftShift(int start, string refAllele, string altAllele)
{
if (refAllele == null || altAllele == null)
{
return(start, refAllele, altAllele);
}
return(_aligner.LeftAlign(start, refAllele, altAllele));
}
private ClinvarVariant LeftShift(ClinvarVariant variant)
{
if (variant.ReferenceAllele == null || variant.AltAllele == null)
{
return(variant);
}
var alignedVariant = _aligner.LeftAlign(variant.Start, variant.ReferenceAllele, variant.AltAllele);
if (alignedVariant == null)
{
return(variant);
}
return(new ClinvarVariant(variant.Chromosome, alignedVariant.Item1, variant.Stop, alignedVariant.Item2, alignedVariant.Item3));
}