/// <summary>
/// Applies the stimulation parameter.
/// If stimulationSetMe == Stimulation.Python-configured, the condition supplied by the Python script is used.
/// </summary>
private void setStimulation()
{
if (stimulationSetMe == Stimulation.Python_configured)
{
stimulation = (Stimulation)(int)Academy.Instance.FloatProperties.GetPropertyWithDefault("stimulation", 0f);
}
else
{
stimulation = stimulationSetMe;
}
}
public override void HandleSignal(Signal signal)
{
if (signal is Antigen <T> )
{
double pampLevel;
var antigen = signal as Antigen <T>;
if (IsPAMP(antigen, out pampLevel))
{
// engulf the pattern if have not any yet
if (Stimulation == null)
{
// process the antigen to obtain its peptides pattern
var peptide = ProcessAntigen(antigen);
// generate stimulation signal using the antigen peptide
Stimulation = new Stimulation(Parent.Address, peptide, 0);
Log("Engulfed an antigen with peptide pattern: " + peptide, LogLevel.Minor);
}
pampSum += pampLevel;
}
}
else if (signal is Sdamp)
{
double dangerLevel;
var sdamp = signal as Sdamp;
if (IsDamp(sdamp, out dangerLevel))
{
// it's a danger signal
dangerSum += dangerLevel;
}
else
{
// it's a safe signal
safeSum += dangerLevel;
}
}
if (Stimulation != null)
{
// update stimulation concentration (co-stimulation)
Stimulation.Concentration = (Globals.DangerSignalWeight * dangerSum) +
(Globals.SafeSignalWeight * safeSum) +
(Globals.PAMPWeight * pampSum);
}
var parentType = ((ITissue)Parent).Type;
// check APC activation
// if dangerSum exceeds a threshold and there is an engulfed pattern
if (dangerSum >= Globals.APCMigrationThreshold && Stimulation != null && !migrateRequestSent)
{
Log("APC activated in node " + Parent.Address);
ActivatedIn = Parent.Address;
// set costimulation secretion timer
Log("Starting co-stimulation expression timer.", LogLevel.Minor);
Scheduler.Schedule(ExpressCostimulation, CostimulationInterval);
// migrate to a lymph node by asking my parent to send me to a lymph node
Log("Migrating to a lymph node.", LogLevel.Minor);
Secrete(new Cytokine(Address, CytokineType.IL1, 1));
migrateRequestSent = true;
}
base.HandleSignal(signal);
}
