Пример #1
0
        private void convertTransportContainer(TransporterExpressionContainer expressionContainerToConvert, IReadOnlyList <TransporterExpressionContainer> allTransporterExpressionContainers)
        {
            //This should never happen as a tag was added in the xml conversion with the membrane location
            if (!expressionContainerToConvert.Tags.Any())
            {
                return;
            }

            var membraneLocation = EnumHelper.ParseValue <MembraneLocation>(expressionContainerToConvert.Tags.ElementAt(0).Value);

            var matchingContainers = allTransporterExpressionContainers
                                     .Where(x => x.LogicalContainerName == expressionContainerToConvert.Name || x.CompartmentName == expressionContainerToConvert.Name)
                                     .ToList();

            //only one direction to take into consideration. all good, nothing else to do
            if (matchingContainers.Count == 1)
            {
                return;
            }

            MembraneLocationConverter.ConvertMembraneLocationToParameterFraction(matchingContainers, membraneLocation);
        }
Пример #2
0
        public override async Task <MoleculeExpressionContainer> MapToModel(ExpressionContainer snapshot, ExpressionContainerMapperContext snapshotContext)
        {
            if (snapshot == null)
            {
                return(null);
            }

            var molecule = snapshotContext.Molecule;
            var expressionParameterCache      = snapshotContext.ExpressionParameters;
            var expressionContainerParameters = snapshotContext.MoleculeExpressionContainers;

            //Value was only defined for older version of the snapshot
            if (snapshot.Value.HasValue)
            {
                var relExp = expressionParameterCache[snapshot.Name];
                if (relExp == null)
                {
                    _logger.AddWarning(PKSimConstants.Error.RelativeExpressionContainerNotFound(snapshot.Name));
                    return(null);
                }

                await _parameterMapper.MapToModel(snapshot, new ParameterSnapshotContext(relExp, snapshotContext));
            }


            //We do not return anything as container are created at construction time
            if (!(molecule is IndividualTransporter transporter))
            {
                return(null);
            }

            var expressionsContainers = expressionContainerParameters.OfType <TransporterExpressionContainer>()
                                        .Where(queryPredicate(snapshotContext.IsV9FormatOrEarlier, snapshot))
                                        .Where(x => x.TransportDirection != TransportDirectionId.None)
                                        .ToList();

            if (expressionsContainers.Count == 0)
            {
                _logger.AddWarning(PKSimConstants.Error.RelativeExpressionContainerNotFound(snapshot.Name));
                return(null);
            }

            var firstExpressionContainer = expressionsContainers[0];

            //This is the new format
            if (!snapshotContext.IsV9FormatOrEarlier)
            {
                //we should only have one
                firstExpressionContainer.TransportDirection = snapshot.TransportDirection.Value;
                return(firstExpressionContainer);
            }

            expressionsContainers.Each(x => x.TransportDirection = TransportDirections.DefaultDirectionFor(transporter.TransportType, x));

            //only one direction to take into consideration. all good, nothing else to do
            if (expressionsContainers.Count == 1)
            {
                return(firstExpressionContainer);
            }

            //This is the old format. Basolateral was the default
            var membraneLocation = ModelValueFor(snapshot.MembraneLocation, MembraneLocation.Basolateral);

            MembraneLocationConverter.ConvertMembraneLocationToParameterFraction(expressionsContainers, membraneLocation);
            return(firstExpressionContainer);
        }