public override void GlobalContext()
{
base.GlobalContext();
_objectPathFactory = IoC.Resolve <IObjectPathFactory>();
_modelCoreSimulation = IoC.Resolve <SimulationHelperForSpecs>().CreateSimulation();
var simModelExporter = IoC.Resolve <ISimModelExporter>();
var simModelSimulationFactory = A.Fake <ISimModelSimulationFactory>();
A.CallTo(() => simModelSimulationFactory.Create()).Returns(new Simulation());
_simModelManagerForSpecs = new SimModelManagerForSpecs(simModelExporter, simModelSimulationFactory);
_simModelSimulation = _simModelManagerForSpecs.CreateSimulation(_modelCoreSimulation);
_dataFactory = A.Fake <IDataFactory>();
_variableParameterPaths = new[]
{
_objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism, ConstantsForSpecs.BW).PathAsString,
_objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism, ConstantsForSpecs.TableParameter1).PathAsString,
};
_variableSpeciesPath = new []
{
_objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism, ConstantsForSpecs.ArterialBlood, ConstantsForSpecs.Plasma, "A").PathAsString,
_objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism, ConstantsForSpecs.VenousBlood, ConstantsForSpecs.Plasma, "B").PathAsString,
};
sut = new SimModelBatch(simModelExporter, simModelSimulationFactory, _dataFactory);
}
private void setupParticleBin(IApplicationBuilder applicBuilder, int binIndex, double binRadius, double binNumberOfParticlesFactor, IFormulaCache formulaCache)
{
var binName = binContainerName(binIndex);
var binContainer = applicBuilder.GetSingleChildByName <IContainer>(binName);
var numberOfParticlesFactor = binContainer.Parameter(CoreConstants.Parameters.NUMBER_OF_PARTICLES_FACTOR);
numberOfParticlesFactor.Value = binNumberOfParticlesFactor;
var particleRadius = binContainer.Parameter(CoreConstants.Parameters.START_PARTICLE_RADIUS);
particleRadius.Value = binRadius;
// add application molecule in particle bin and set its formula
var appMoleculeBuilder = _objectBaseFactory.Create <IApplicationMoleculeBuilder>().WithName(solubleMoleculeName(binIndex));
appMoleculeBuilder.RelativeContainerPath = _objectPathFactory.CreateObjectPathFrom(binName);
appMoleculeBuilder.Formula = particleDrugMassFormula(formulaCache);
applicBuilder.AddMolecule(appMoleculeBuilder);
// add insoluble molecule for particle bin
appMoleculeBuilder = _objectBaseFactory.Create <IApplicationMoleculeBuilder>().WithName(insolubleMoleculeName(binIndex));
appMoleculeBuilder.RelativeContainerPath = _objectPathFactory.CreateObjectPathFrom(binName, CoreConstants.ContainerName.InsolubleDrug);
appMoleculeBuilder.Formula = insolubleDrugStartFormula(formulaCache);
applicBuilder.AddMolecule(appMoleculeBuilder);
}
/// <summary>
/// Returns the quantity and the consolidated object path of that quantity in the simulation (adding the simulation name
/// at the beginning)
/// </summary>
/// <param name="simulation"></param>
/// <param name="path"></param>
/// <returns></returns>
private Tuple <IQuantity, IObjectPath> quantityAndPathFrom(Simulation simulation, IEnumerable <string> path)
{
var objectPath = _objectPathFactory.CreateObjectPathFrom(path).AndAddAtFront(simulation.Name);
var quantity = objectPath.TryResolve <IQuantity>(simulation.Model.Root);
return(new Tuple <IQuantity, IObjectPath>(quantity, objectPath));
}
private string pathWithoutSimulationName(string simulationPath)
{
var quantityPath = _objectPathFactory.CreateObjectPathFrom(simulationPath.ToPathArray());
quantityPath.Remove(_simulationName);
return(quantityPath.PathAsString);
}
protected TMoleculeExpressionContainer AddVascularSystemExpression(TMolecule protein, string surrogateName)
{
var expressionContainer = addContainerExpression(protein, surrogateName, CoreConstants.Groups.VASCULAR_SYSTEM);
expressionContainer.OrganPath = _objectPathFactory.CreateObjectPathFrom(surrogateName);
return(expressionContainer);
}
/// <summary>
/// Add start formula for the drug molecule. Will be created in the root application container
/// </summary>
private void addDrugStartFormula(IApplicationBuilder applicationBuilder, IFormulaCache formulaCache)
{
var applicationMoleculeBuilder = _objectBaseFactory.Create <IApplicationMoleculeBuilder>().WithName(applicationBuilder.Name);
applicationMoleculeBuilder.RelativeContainerPath = _objectPathFactory.CreateObjectPathFrom(ObjectPath.PARENT_CONTAINER, applicationBuilder.Name);
applicationMoleculeBuilder.Formula = _formulaFactory.DrugMassFormulaFor(formulaCache);
applicationBuilder.AddMolecule(applicationMoleculeBuilder);
}
private DataTable createPopInitialValues()
{
var dt = new DataTable("InitialValues");
dt.Columns.Add(Constants.Population.INDIVIDUAL_ID_COLUMN);
var path = _objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism,
ConstantsForSpecs.ArterialBlood,
ConstantsForSpecs.Plasma,
"A").PathAsString;
dt.Columns.Add(path);
path = _objectPathFactory.CreateObjectPathFrom(ConstantsForSpecs.Organism,
ConstantsForSpecs.VenousBlood,
ConstantsForSpecs.Plasma,
"A").PathAsString;
dt.Columns.Add(path);
dt.Rows.Add(0, 1.1, 2.2);
dt.Rows.Add(1, 3.3, 4.4);
dt.Rows.Add(2, 5.5, 6.6);
return(dt);
}
public override object ConvertFrom(string attributeValue, SerializationContext context)
{
if (string.IsNullOrEmpty(attributeValue))
{
return(new ObjectPath());
}
return(_objectPathFactory.CreateObjectPathFrom(attributeValue.ToPathArray()));
}
private IBuildConfiguration createBuildConfiguration()
{
var buildConfiguration = new BuildConfigurationForSpecs();
buildConfiguration.Molecules = getMolecules();
buildConfiguration.Reactions = getReactions();
buildConfiguration.SpatialStructure = getSpatialStructure();
buildConfiguration.PassiveTransports = new PassiveTransportBuildingBlock();
buildConfiguration.Observers = new ObserverBuildingBlock();
buildConfiguration.EventGroups = new EventGroupBuildingBlock();
buildConfiguration.SimulationSettings = createSimulationConfiguration();
buildConfiguration.MoleculeStartValues = _moleculeStartValuesCreator.CreateFrom(buildConfiguration.SpatialStructure, buildConfiguration.Molecules);
var objectPathForContainerThatDoesNotExist = _objectPathFactory.CreateObjectPathFrom("TOTO", "TATA");
buildConfiguration.MoleculeStartValues.Add(_moleculeStartValuesCreator.CreateMoleculeStartValue(objectPathForContainerThatDoesNotExist, "A", _concentrationDimension));
buildConfiguration.ParameterStartValues = _parameterStartValuesCreator.CreateFrom(buildConfiguration.SpatialStructure, buildConfiguration.Molecules);
setMoleculeStartValues(buildConfiguration.MoleculeStartValues);
return(buildConfiguration);
}
/// <summary>
/// Get Results from SimModel
/// </summary>
/// <param name="simulation">SimModel simulation</param>
/// <param name="individualId">Individual id</param>
private IndividualResults individualResultsFrom(SimModelNET.ISimulation simulation, int individualId)
{
var results = new IndividualResults {
IndividualId = individualId
};
var simulationTimes = simulation.SimulationTimes;
var simulationTimesLength = simulationTimes.Length;
foreach (var result in simulation.AllValues)
{
//Add quantity name and remove simulation name
var quantityPath = _objectPathFactory.CreateObjectPathFrom(result.Path.ToPathArray());
quantityPath.Remove(_simulationName);
results.Add(quantityValuesFor(quantityPath.ToString(), result, simulationTimesLength));
}
results.Time = quantityValuesFor(Constants.TIME, simulation.SimulationTimes);
return(results);
}
public IObjectPath MapFrom(long flatObjectPathId)
{
FlatRelativeObjectPath flatObjectPath = _flatObjectPathRepo.FlatRelativeObjectPathFor(flatObjectPathId);
var relativePath = new List <string>();
//first entry
if (flatObjectPath.ContainerName != CoreConstants.ORM.ContainerMe)
{
relativePath.Add(flatObjectPath.ContainerName);
}
while (flatObjectPath.PathId != flatObjectPath.ParentPathId)
{
flatObjectPath = _flatObjectPathRepo.FlatRelativeObjectPathFor(flatObjectPath.ParentPathId);
if (flatObjectPath.ContainerName != CoreConstants.ORM.ContainerMe)
{
relativePath.Add(flatObjectPath.ContainerName);
}
}
relativePath.Reverse();
return(_objectPathFactory.CreateObjectPathFrom(relativePath.ToArray()));
}
private IObjectPath moleculeGlobalPathFor(string moleculeName)
{
return(_objectPathFactory.CreateObjectPathFrom(moleculeName));
}
private IParameterStartValue globalMoleculeParameterValueFor(IMoleculeBuilder moleculeBuilder, IParameter parameterTemplate)
{
var parameterPath = _objectPathFactory.CreateObjectPathFrom(moleculeBuilder.Name, parameterTemplate.Name);
return(CreateParameterStartValue(parameterPath, parameterTemplate));
}