/// <summary>
/// Initializes a new instance of the <see cref="PrecursorSequenceIonViewModel"/> class.
/// </summary>
public PrecursorSequenceIonViewModel()
{
FragmentationSequence = new FragmentationSequence(
new Sequence(new List <AminoAcid>()),
1,
null,
ActivationMethod.HCD);
HeavyModifications = new SearchModification[0];
PrecursorViewMode = PrecursorViewMode.Isotopes;
LabeledIonViewModels = new LabeledIonViewModel[0];
this.WhenAnyValue(x => x.ChargeViewMode).Subscribe(chargeViewMode => IsotopeViewMode = !chargeViewMode);
this.WhenAnyValue(x => x.IsotopeViewMode).Subscribe(isotopeViewMode => ChargeViewMode = !isotopeViewMode);
this.WhenAnyValue(x => x.IsotopeViewMode).Subscribe(isotopeViewMode =>
PrecursorViewMode = isotopeViewMode ? PrecursorViewMode.Isotopes : PrecursorViewMode.Charges);
this.WhenAnyValue(x => x.PrecursorViewMode).Subscribe(
viewMode =>
{
IsotopeViewMode = viewMode == PrecursorViewMode.Isotopes;
ChargeViewMode = viewMode == PrecursorViewMode.Charges;
});
this.WhenAnyValue(x => x.PrecursorViewMode, x => x.RelativeIntensityThreshold, x => x.HeavyModifications, x => x.FragmentationSequence)
.SelectMany(async _ => await GetLabeledIonViewModels())
.Subscribe(livms => LabeledIonViewModels = livms);
}
/// <summary>
/// Initializes a new instance of the <see cref="FragmentationSequenceViewModel"/> class.
/// </summary>
public FragmentationSequenceViewModel()
{
FragmentationSequence = new FragmentationSequence(
new Sequence(new List <AminoAcid>()),
1,
null,
ActivationMethod.HCD);
var baseIonTypes = BaseIonType.AllBaseIonTypes.Select(
bit =>
new BaseIonTypeViewModel
{
BaseIonType = bit,
IsSelected = bit == BaseIonType.B || bit == BaseIonType.Y
});
BaseIonTypes = new ReactiveList <BaseIonTypeViewModel>(baseIonTypes)
{
ChangeTrackingEnabled = true
};
NeutralLosses = new ReactiveList <NeutralLossViewModel>
{
new NeutralLossViewModel {
NeutralLoss = NeutralLoss.NoLoss, IsSelected = true
},
new NeutralLossViewModel {
NeutralLoss = NeutralLoss.H2O
},
new NeutralLossViewModel {
NeutralLoss = NeutralLoss.NH3
}
};
NeutralLosses.ChangeTrackingEnabled = true;
HeavyModifications = new SearchModification[0];
LabeledIonViewModels = new LabeledIonViewModel[0];
SelectedIonTypes = new IonType[0];
AddPrecursorIons = true;
// HideAllIonsCommand deselects all ion types and neutral losses.
HideAllIonsCommand = ReactiveCommand.Create(() =>
{
AddPrecursorIons = false;
foreach (var baseIonType in BaseIonTypes)
{
baseIonType.IsSelected = false;
}
foreach (var neutralLoss in NeutralLosses)
{
neutralLoss.IsSelected = neutralLoss.NeutralLoss == NeutralLoss.NoLoss && neutralLoss.IsSelected;
}
});
// When Base Ion Types are selected/deselected, update ion types.
BaseIonTypes.ItemChanged.Where(x => x.PropertyName == "IsSelected")
.Select(_ => GetIonTypes())
.Subscribe(ionTypes => SelectedIonTypes = ionTypes);
// When Neutral Losses are selected/deselected, update ion types
NeutralLosses.ItemChanged.Where(x => x.PropertyName == "IsSelected")
.Select(_ => GetIonTypes())
.Subscribe(ionTypes => SelectedIonTypes = ionTypes);
// When FragmentationSequence is set, select IonTypes for ActivationMethod.
this.WhenAnyValue(x => x.FragmentationSequence)
.Where(fragSeq => fragSeq != null)
.Subscribe(fragSeq => SetActivationMethod(fragSeq.ActivationMethod));
// When fragmentation sequence changes, update labeled ions
this.WhenAnyValue(x => x.FragmentationSequence, x => x.SelectedIonTypes, x => x.HeavyModifications, x => x.AddPrecursorIons)
.SelectMany(async _ => await GetLabeledIonViewModels())
.Subscribe(livms => LabeledIonViewModels = livms);
SelectAllIonsCommand = ReactiveCommand.Create(() =>
{
foreach (var ion in BaseIonTypes)
{
ion.IsSelected = true;
}
AddPrecursorIons = true;
});
IcParameters.Instance.WhenAnyValue(x => x.CidHcdIonTypes, x => x.EtdIonTypes)
.Throttle(TimeSpan.FromMilliseconds(50), RxApp.TaskpoolScheduler)
.Where(_ => FragmentationSequence != null)
.Subscribe(_ => SetActivationMethod(FragmentationSequence.ActivationMethod));
}
