public void should_include_parameters_that_have_a_distributed_formula()
{
var parameter = DomainHelperForSpecs.NormalDistributedParameter(defaultMean: 10);
A.CallTo(() => _parameterSelector.CanUseParameter(parameter)).Returns(true);
sut.ParameterCanBeUsedForSensitivity(parameter).ShouldBeTrue();
}
protected override void Context()
{
base.Context();
_formulaParameter = DomainHelperForSpecs.ConstantParameterWithValue(10);
_formulaParameter.Formula = new ExplicitFormula("10");
_constantParameter = DomainHelperForSpecs.ConstantParameterWithValue(10);
_distributedParameter = DomainHelperForSpecs.NormalDistributedParameter();
}
protected override void Context()
{
_organism = new Container().WithName(Constants.ORGANISM);
_liver = new Container().WithName("Liver");
_kidney = new Container().WithName("Kidney");
_liverIntracellular = new Container().WithName(INTRACELLULAR);
_kidneyIntracellular = new Container().WithName(INTRACELLULAR);
_liverRelExp = DomainHelperForSpecs.ConstantParameterWithValue(10).WithName("Relative expression (normalized)");
_volumeLiver = DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.VOLUME);
_volumeLiver.Formula = new ExplicitFormula("1+2");
_volumeOrganism = DomainHelperForSpecs.ConstantParameterWithValue(20).WithName(Constants.Parameters.VOLUME);
_volumeLiverCell = DomainHelperForSpecs.ConstantParameterWithValue(5).WithName(Constants.Parameters.VOLUME);
_liverIntracellularSubContainer = new Container().WithName("Intracellular Sub Container");
_volumeKidneyCell = DomainHelperForSpecs.ConstantParameterWithValue(3).WithName(Constants.Parameters.VOLUME);
_gfr = DomainHelperForSpecs.NormalDistributedParameter(3).WithName("GFR");
_volumeKidney = DomainHelperForSpecs.ConstantParameterWithValue(14).WithName(Constants.Parameters.VOLUME);
_height = DomainHelperForSpecs.ConstantParameterWithValue(175).WithName("Height");
_weight = DomainHelperForSpecs.ConstantParameterWithValue(75).WithName("Weight");
_paramWithRHS = DomainHelperForSpecs.ConstantParameterWithValue(10).WithName("RHSParam");
_paramWithRHS.RHSFormula = new ExplicitFormula();
_clearance = DomainHelperForSpecs.ConstantParameterWithValue(5).WithName("CL");
_organism.AddChildren(_liver, _kidney, _height, _weight, _volumeOrganism, _paramWithRHS);
_liver.AddChildren(_liverIntracellular, _volumeLiver);
_liverIntracellular.AddChildren(_volumeLiverCell, _liverIntracellularSubContainer, _liverRelExp);
_liverIntracellularSubContainer.Add(_clearance);
_kidney.AddChildren(_kidneyIntracellular, _volumeKidney);
_kidneyIntracellular.AddChildren(_volumeKidneyCell, _gfr);
_liverIntracellularMoleculeAmount = new MoleculeAmount().WithName("Drug");
_liverIntracellular.Add(_liverIntracellularMoleculeAmount);
_simulation = A.Fake <ISimulation>();
_simulation.Model.Root = _organism;
}
protected override void Context()
{
base.Context();
_parameter = DomainHelperForSpecs.NormalDistributedParameter();
_parameter.Percentile = 0.3;
}
protected override void Context()
{
base.Context();
_parameter = DomainHelperForSpecs.NormalDistributedParameter();
_parameter.Value = 1.2;
}
