// Functions to get the requested value
// Requires that events are sorted by ascending chartDateTime.
public GenericEvent GetLatestOutputEvent(string[] names, DateTime timestamp)
{
GenericEvent result = null;
foreach (GenericEvent genericEvent in events)
{
if (genericEvent.chartDateTime >= timestamp)
{
break;
}
if (genericEvent.type == "labevent" && names.Contains(genericEvent.label))
{
result = genericEvent;
}
}
return(result);
}
// Create a testcase for hypokalemia from a generic MIMIC III testcase
TestcaseHypokalemia(Testcase testcase)
{
// Find the first prescription for a potassium suplement
DateTime treatmentTimestamp = DateTime.UtcNow;
// Store the first prescription as the expected result for analysis
// Find the inputs for the hypokalemia algorithm
// GFR (ml/min)
// Get the age
double age = testcase.age(treatmentTimestamp);
if (age >= 0)
{
GenericEvent firstCreatinineEvent = testcase.GetLatestLabEvent(new string[] { "creatinine" }, treatmentTimestamp);
GenericEvent secondCreatinineEvent = null;
if (firstCreatinineEvent != null)
{
double GFR1 = GFR(firstCreatinineEvent.valueNum, age, testcase.ethnicity, testcase.gender);
if (GFR1 > 0.0)
{
testData.SetValue("gfr", GFR1, "mL/min/1.73 m2", firstCreatinineEvent.chartDateTime);
double GFR2 = -1;
secondCreatinineEvent = testcase.GetLatestLabEvent(new string[] { "creatinine" }, firstCreatinineEvent.chartDateTime);
if (secondCreatinineEvent != null)
{
GFR2 = GFR(secondCreatinineEvent.valueNum, age, testcase.ethnicity, testcase.gender);
if (GFR2 >= 0.0)
{
testData.SetValue("gfr", GFR2, "mL/min/1.73 m2", secondCreatinineEvent.chartDateTime);
}
}
}
}
else
{
results.actions.Add(new AutoICU.AI.Action("Creatinine missing."));
results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Creatinine is required to calculate the estimated GFR."));
return;
}
}
else
{
results.actions.Add(new AutoICU.AI.Action("Age missing."));
results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Age is required to calculate the estimated GFR."));
return;
}
// Urine Production (ml/kg/hr)
// Get the last weight
GenericEvent weightEvent = testcase.GetLatestEvent(new string[] { "weight" }, treatmentTimestamp);
if (weightEvent != null)
{
double weight = weightEvent.valueNum;
DateTime previousDate = treatmentTimestamp.AddDays(-1);
DateTime firstTimestamp = treatmentTimestamp;
DateTime lastTimestamp = firstTimestamp;
double urineProduction = -1;
GenericEvent genericEvent = testcase.GetLatestOutputEvent(new string[] { "foley" }, firstTimestamp);
while (genericEvent != null && genericEvent.valueNum >= 0 && genericEvent.chartDateTime >= previousDate)
{
firstTimestamp = genericEvent.chartDateTime;
if (urineProduction < 0.0)
{
lastTimestamp = firstTimestamp;
urineProduction = 0.0;
}
urineProduction += genericEvent.valueNum;
genericEvent = testcase.GetLatestOutputEvent(new string[] { "foley" }, firstTimestamp);
}
if (firstTimestamp != lastTimestamp)
{
urineProduction -= genericEvent.valueNum;
urineProduction = urineProduction / (lastTimestamp - firstTimestamp).Minutes / 60 / weight;
testData.SetValue("urine production", urineProduction, "ml/kg/hr", lastTimestamp);
}
}
else
{
results.actions.Add(new AutoICU.AI.Action("Weight missing."));
results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Weight is required to calculate the Urine Production."));
return;
}
// Potassium (mEq/l)
GenericEvent labEvent = testcase.GetLatestLabEvent(new string[] { "potassium" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("potassium", labEvent.valueNum, "mEq/l", labEvent.chartDateTime);
}
else
{
results.actions.Add(new AutoICU.AI.Action("Potassium missing."));
results.reasons.Add(new AutoICU.AI.Reason(0, "Required Input", "Potassium is required to determine the recommended treatment."));
return;
}
//values.Add(new ValueSet("Magnesium (mg/dl)"));
labEvent = testcase.GetLatestLabEvent(new string[] { "magnesium" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("magnesium", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
}
//values.Add(new ValueSet("Phosphorus (mg/dl)"));
labEvent = testcase.GetLatestLabEvent(new string[] { "phosphorus" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("phosphorus", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
}
//values.Add(new ValueSet("Calcium, Ionized (mg/dl)"));
labEvent = testcase.GetLatestLabEvent(new string[] { "calcium, ionized" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("calcium, ionized", labEvent.valueNum, "mg/dl", labEvent.chartDateTime);
}
else
{
labEvent = testcase.GetLatestLabEvent(new string[] { "calcium, total" }, treatmentTimestamp);
if (labEvent != null)
{
double totalCalcium = labEvent.valueNum;
labEvent = testcase.GetLatestLabEvent(new string[] { "albumin" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("calcium, corrected", totalCalcium + 0.8 * (4.0 - Math.Min(4.0, labEvent.valueNum)),
"mg/dl", labEvent.chartDateTime);
}
}
}
//values.Add(new ValueSet("Diarrhea (Y/N)"));
labEvent = testcase.GetLatestLabEvent(new string[] { "diarrhea" }, treatmentTimestamp);
if (labEvent != null)
{
testData.SetValue("diarrhea", "Y", "", treatmentTimestamp);
}
else
{
testData.SetValue("diarrhea", "N", "", treatmentTimestamp);
}
//treatments.Add(new ValueSet("KCL (mEq)"));
DateTime earliestTreatmentDate = treatmentTimestamp.AddDays(-2);
DateTime latestTimestamp = treatmentTimestamp;
List <GenericEvent> prescriptionEvents = testcase.GetLatestPrescriptionEvents(hypokalemiaTreatments, earliestTreatmentDate, treatmentTimestamp);
foreach (GenericEvent prescriptionEvent in prescriptionEvents)
{
testData.SetValue("kcl", prescriptionEvent.valueNum, prescriptionEvent.valueUnits, prescriptionEvent.chartDateTime);
}
}