/// <summary>
/// Author: Ryan Liang
/// </summary>
protected void Download_Button_Click(object sender, EventArgs e)
{
SNV_ID_Key = (string)Session["SNV_ID_Key"];
Response.ClearContent();
Response.Clear();
Response.ContentType = "application/x-unknown";
Response.AddHeader("Content-Disposition", "attachment; " +
"filename=DrugProNET_SNV ID " + SNV_ID_Key + ".xlsx");
List <string> header = new List <string>()
{
"Drug Name", "PDB File No.", "Drug PDB No.",
"Drug PubChem CID", "Drug ChEMBL ID", "Importance for Drug", "Effect of Mutation"
};
drugs = (List <Drug_Information>)Session["drugs"];
interactions = (List <PDB_Interaction>)Session["interactions"];
mutations = (List <SNV_Mutation>)Session["mutations"];
List <List <string> > data = new List <List <string> >();
for (int i = 0; i < mutations.Count; i++)
{
List <string> dataRow = new List <string>
{
drugs[i]?.Drug_Common_Name,
mutations[i]?.PDB_File_ID,
mutations[i]?.Drug_PDB_ID,
drugs[i]?.PubChem_CID,
drugs[i]?.ChEMBL_ID,
interactions[i]?.Interaction_Distance_Ratio,
FindPredictedEffiency(mutations[i])
};
data.Add(dataRow);
}
Response.BinaryWrite(ExcelWriter.CreateAsStream(header, data).ToArray());
Response.Flush();
Response.SuppressContent = true;
System.Web.HttpContext.Current.ApplicationInstance.CompleteRequest();
}
/// <summary>
/// Author: Ryan Liang
/// </summary>
protected void Download_SNV_Identification_Click(object sender, EventArgs e)
{
Response.ClearContent();
Response.Clear();
Response.ContentType = "application/x-unknown";
Response.AddHeader("Content-Disposition", "attachment; " +
"filename=DrugProNET_SNV " + Session["SNV_Key"] + ".xlsx");
mutation = (SNV_Mutation)Session["mutation"];
List <string> header = new List <string>()
{
"Variant ID", "SNV", "Predicted Effect on Drug Binding"
};
List <List <string> > data = new List <List <string> >()
{
new List <string>()
{
mutation.P1W, mutation.SNV_P1W_ID, mutation.Drug_Inter__Pred__P1W
},
new List <string>()
{
mutation.P2W, mutation.SNV_P2W_ID, mutation.Drug_Inter__Pred__P2W
},
new List <string>()
{
mutation.P3W, mutation.SNV_P3W_ID, mutation.Drug_Inter__Pred__P3W
},
new List <string>()
{
mutation.P1M1, mutation.SNV_P1M1_ID, mutation.Drug_Inter__Pred__P1M1
},
new List <string>()
{
mutation.P1M2, mutation.SNV_P1M2_ID, mutation.Drug_Inter__Pred__P1M2
},
new List <string>()
{
mutation.P1M3, mutation.SNV_P1M3_ID, mutation.Drug_Inter__Pred__P1M3
},
new List <string>()
{
mutation.P2M1, mutation.SNV_P2M1_ID, mutation.Drug_Inter__Pred__P2M1
},
new List <string>()
{
mutation.P2M2, mutation.SNV_P2M2_ID, mutation.Drug_Inter__Pred__P2M2
},
new List <string>()
{
mutation.P2M3, mutation.SNV_P2M3_ID, mutation.Drug_Inter__Pred__P2M3
},
new List <string>()
{
mutation.P3M1, mutation.SNV_P3M1_ID, mutation.Drug_Inter__Pred__P3M1
},
new List <string>()
{
mutation.P3M2, mutation.SNV_P3M2_ID, mutation.Drug_Inter__Pred__P3M2
},
new List <string>()
{
mutation.P3M3, mutation.SNV_P3M3_ID, mutation.Drug_Inter__Pred__P3M3
},
};
Response.BinaryWrite(ExcelWriter.CreateAsStream(header, data).ToArray());
Response.Flush();
Response.SuppressContent = true;
System.Web.HttpContext.Current.ApplicationInstance.CompleteRequest();
}
/// <summary>
/// Author: Ryan Liang
/// </summary>
protected void Download_List_Click(object sender, EventArgs e)
{
try
{
Dictionary <PDB_Distance, string> DistanceAndUniprotResidueNumbers = (Dictionary <PDB_Distance, string>)Session["DistanceAndUniprotResidueNumbers"];
interaction_distance = (double)Session["interaction_distance"];
protein_chain = (bool)Session["protein_chain"];
protein_atoms = (bool)Session["protein_atoms"];
protein_residues = (bool)Session["protein_residues"];
protein_residue_numbers = (bool)Session["protein_residue_numbers"];
drug_atoms = (bool)Session["drug_atoms"];
Response.ClearContent();
Response.Clear();
Response.ContentType = "application/x-unknown";
Response.AddHeader("Content-Disposition", "attachment; " +
"filename=DrugProNET_PDB ID " + Session["PDB_File_ID"] + "_Bond Distance " +
Session["interaction_distance"] + " Å_Atom Interactions.xlsx");
List <string> header = new List <string>()
{
"Distance (Å)",
};
if (protein_chain)
{
header.Add("Protein Chain");
}
if (protein_residue_numbers)
{
header.Add("Protein Residue #");
}
if (protein_residues)
{
header.Add("Amino Acid Residue Type");
}
if (protein_atoms)
{
header.Add("Amino Acid Residue Atom");
}
if (drug_atoms)
{
header.Add("Drug Atom");
}
List <List <string> > data = new List <List <string> >();
foreach (KeyValuePair <PDB_Distance, string> kvp in DistanceAndUniprotResidueNumbers)
{
List <string> dataRow = new List <string>
{
kvp.Key.Distance.ToString()
};
if (protein_chain)
{
dataRow.Add(kvp.Key.Protein_Chain);
}
if (protein_residue_numbers)
{
dataRow.Add(kvp.Value);
}
if (protein_residues)
{
dataRow.Add(kvp.Key.Protein_Residue);
}
if (protein_atoms)
{
dataRow.Add(kvp.Key.Protein_Atom);
}
if (drug_atoms)
{
dataRow.Add(kvp.Key.Compound_Atom);
}
data.Add(dataRow);
}
Response.BinaryWrite(ExcelWriter.CreateAsStream(header, data).ToArray());
Response.Flush();
Response.SuppressContent = true;
System.Web.HttpContext.Current.ApplicationInstance.CompleteRequest();
}
catch (Exception)
{
ExceptionUtilities.DisplayAlert(this, DEFAULT_REDIRECT_PAGE);
}
}