public BRAFV600EKResultPage(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf,
YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
YellowstonePathology.Business.User.SystemIdentity systemIdentity,
YellowstonePathology.UI.Navigation.PageNavigator pageNavigator,
System.Windows.Visibility backButtonVisibility)
: base(panelSetOrderBraf, accessionOrder)
{
this.m_PanelSetOrder = panelSetOrderBraf;
this.m_AccessionOrder = accessionOrder;
this.m_SystemIdentity = systemIdentity;
this.m_PageNavigator = pageNavigator;
this.m_BackButtonVisibility = backButtonVisibility;
this.m_PageHeaderText = "BRAF V600E/K Mutation Analysis Results For: " + this.m_AccessionOrder.PatientDisplayName + " (" + panelSetOrderBraf.ReportNo + ")";
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetByAliquotOrderId(this.m_PanelSetOrder.OrderedOnId);
YellowstonePathology.Business.Test.AliquotOrder aliquotOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetAliquotOrder(this.m_PanelSetOrder.OrderedOnId);
this.m_OrderedOnDescription = specimenOrder.Description + ": " + aliquotOrder.Label;
this.m_IndicationCollection = YellowstonePathology.Business.Test.IndicationCollection.GetAll();
this.m_ResultCollection = YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKResultCollection.GetUniqueResultChoices();
InitializeComponent();
this.m_ParentWindow = Window.GetWindow(this);
DataContext = this;
this.m_ControlsNotDisabledOnFinal.Add(this.ButtonBack);
this.m_ControlsNotDisabledOnFinal.Add(this.ButtonNext);
this.m_ControlsNotDisabledOnFinal.Add(this.TextBlockShowDocument);
this.m_ControlsNotDisabledOnFinal.Add(this.TextBlockUnfinalResults);
}
public BRAFV600EKResultPage(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf,
YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
YellowstonePathology.Business.User.SystemIdentity systemIdentity,
YellowstonePathology.UI.Navigation.PageNavigator pageNavigator,
System.Windows.Visibility backButtonVisibility) : base(panelSetOrderBraf, accessionOrder)
{
this.m_PanelSetOrder = panelSetOrderBraf;
this.m_AccessionOrder = accessionOrder;
this.m_SystemIdentity = systemIdentity;
this.m_PageNavigator = pageNavigator;
this.m_BackButtonVisibility = backButtonVisibility;
this.m_PageHeaderText = "BRAF V600E/K Mutation Analysis Results For: " + this.m_AccessionOrder.PatientDisplayName + " (" + panelSetOrderBraf.ReportNo + ")";
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetByAliquotOrderId(this.m_PanelSetOrder.OrderedOnId);
YellowstonePathology.Business.Test.AliquotOrder aliquotOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetAliquotOrder(this.m_PanelSetOrder.OrderedOnId);
this.m_OrderedOnDescription = specimenOrder.Description + ": " + aliquotOrder.Label;
this.m_IndicationCollection = YellowstonePathology.Business.Test.IndicationCollection.GetAll();
this.m_ResultCollection = YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKResultCollection.GetUniqueResultChoices();
InitializeComponent();
this.m_ParentWindow = Window.GetWindow(this);
DataContext = this;
this.m_ControlsNotDisabledOnFinal.Add(this.ButtonBack);
this.m_ControlsNotDisabledOnFinal.Add(this.ButtonNext);
this.m_ControlsNotDisabledOnFinal.Add(this.TextBlockShowDocument);
this.m_ControlsNotDisabledOnFinal.Add(this.TextBlockUnfinalResults);
}
public override void SetState(YellowstonePathology.Business.Test.AccessionOrder accessionOrder)
{
base.SetState(accessionOrder);
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest krasStandardReflexTest = new YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest();
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId) == true) // || this.m_AccessionOrder.PanelSetOrderCollection.Exists(krasStandardReflexTest.PanelSetId) == true)
{
this.m_HasPanelSetBeenOrdered = true;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetBrafPanelSetOrder();
if (panelSetOrderBraf.Final == true)
{
this.m_IsStepComplete = true;
if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.Detected)
{
this.m_Stop = true;
this.m_IsStepComplete = true;
}
else if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.NotDetected)
{
this.m_NextStep = new LynchMLH1ByPCRStep();
}
}
}
}
protected Rules.MethodResult HasFinalBRAFResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation)
{
Rules.MethodResult result = new Rules.MethodResult();
result.Success = false;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTest brafMutationAnalysisTest = new BRAFMutationAnalysis.BRAFMutationAnalysisTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderBraf.Final == true)
{
result.Success = true;
result.Message = panelSetOrderBraf.GetSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + brafV600EKTest.PanelSetName + " is not final.";
}
}
else if (accessionOrder.PanelSetOrderCollection.Exists(brafMutationAnalysisTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder brafMutationAnalysisTestOrder = (YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafMutationAnalysisTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (brafMutationAnalysisTestOrder.Final == true)
{
result.Success = true;
result.Message = brafMutationAnalysisTestOrder.GetSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + brafMutationAnalysisTest.PanelSetName + " is not final.";
}
}
else if (accessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderRASRAF.Final == true)
{
result.Success = true;
result.Message = panelSetOrderRASRAF.GetBrafSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + rasRAFPanelTest.PanelSetName + " is not final.";
}
}
if (result.Success == false && string.IsNullOrEmpty(result.Message) == true)
{
result.Message = "Unable to set results as a BRAF has not been ordered.";
}
return(result);
}
public override void Render()
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_PanelSetOrder;
base.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\BRAFV600EK.3.xml";
base.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
this.SetCaseHistory();
string brafResult = panelSetOrder.Result;
this.SetXmlNodeData("report_result", brafResult);
this.SetXmlNodeData("final_date", YellowstonePathology.Business.BaseData.GetShortDateString(this.m_PanelSetOrder.FinalDate));
YellowstonePathology.Business.Amendment.Model.AmendmentCollection amendmentCollection = this.m_AccessionOrder.AmendmentCollection.GetAmendmentsForReport(m_PanelSetOrder.ReportNo);
YellowstonePathology.Business.Document.AmendmentSection amendmentSection = new YellowstonePathology.Business.Document.AmendmentSection();
amendmentSection.SetAmendment(amendmentCollection, this.m_ReportXml, this.m_NameSpaceManager, true);
if (amendmentCollection.Count == 0)
{
this.SetXmlNodeData("test_result_header", "Test Result");
}
else // If an amendment exists show as corrected
{
this.SetXmlNodeData("test_result_header", "Corrected Test Result");
}
if (string.IsNullOrEmpty(panelSetOrder.Comment) == false)
{
this.ReplaceText("result_comment", panelSetOrder.Comment);
}
else
{
this.DeleteRow("result_comment");
}
this.ReplaceText("report_interpretation", panelSetOrder.Interpretation);
this.ReplaceText("report_indication_comment", panelSetOrder.IndicationComment);
this.ReplaceText("tumor_nuclei_percent", panelSetOrder.TumorNucleiPercentage);
this.ReplaceText("report_method", panelSetOrder.Method);
this.ReplaceText("report_reference", panelSetOrder.ReportReferences);
this.ReplaceText("report_disclaimer", panelSetOrder.ReportDisclaimer);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(this.m_PanelSetOrder.OrderedOn, this.m_PanelSetOrder.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.SetXmlNodeData("date_time_collected", collectionDateTimeString);
this.ReplaceText("report_date", YellowstonePathology.Business.BaseData.GetShortDateString(this.m_PanelSetOrder.FinalDate));
this.SetXmlNodeData("pathologist_signature", m_PanelSetOrder.Signature);
this.SaveReport();
}
public virtual void SetResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder brafv600ekTestOrder)
{
brafv600ekTestOrder.Result = this.m_Result;
brafv600ekTestOrder.ResultCode = this.m_ResultCode;
brafv600ekTestOrder.Interpretation = this.m_Interpretation;
brafv600ekTestOrder.IndicationComment = this.m_IndicationComment;
brafv600ekTestOrder.Comment = this.m_Comment;
brafv600ekTestOrder.Method = this.m_Method;
brafv600ekTestOrder.ReportReferences = this.m_References;
}
public BRAFV600EKResultPath(string reportNo,
YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
YellowstonePathology.UI.Navigation.PageNavigator pageNavigator,
System.Windows.Visibility backButtonVisibility,
System.Windows.Window window)
: base(pageNavigator, window)
{
this.m_AccessionOrder = accessionOrder;
this.m_PanelSetOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_BackButtonVisibility = backButtonVisibility;
}
public BRAFV600EKResultPath(string reportNo,
YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
YellowstonePathology.UI.Navigation.PageNavigator pageNavigator,
System.Windows.Visibility backButtonVisibility,
System.Windows.Window window)
: base(pageNavigator, window)
{
this.m_AccessionOrder = accessionOrder;
this.m_PanelSetOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_BackButtonVisibility = backButtonVisibility;
}
public KRASStandardReflexResult(string reportNo, Business.Test.AccessionOrder accessionOrder)
{
this.m_AccessionOrder = accessionOrder;
this.m_KRASStandardReflexTest = new KRASStandardReflexTest();
this.m_KRASStandardReflexTestOrder = (YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_KRASStandardTest = new KRASStandard.KRASStandardTest();
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOnId, true);
this.m_BRAFV600EKTest = new BRAFV600EK.BRAFV600EKTest();
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOn, true);
this.m_References = "1. Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(10): 1626-1634. " +
"2. Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007; 67(6): 2643-2648.";
}
public KRASStandardReflexResult(string reportNo, Business.Test.AccessionOrder accessionOrder)
{
this.m_AccessionOrder = accessionOrder;
this.m_KRASStandardReflexTest = new KRASStandardReflexTest();
this.m_KRASStandardReflexTestOrder = (YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_KRASStandardTest = new KRASStandard.KRASStandardTest();
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOnId, true);
this.m_BRAFV600EKTest = new BRAFV600EK.BRAFV600EKTest();
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOn, true);
this.m_References = "1. Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(10): 1626-1634. " +
"2. Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007; 67(6): 2643-2648.";
}
public void UpdateFromChildren(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder testOrder)
{
this.Indication = testOrder.Indication;
this.IndicationComment = testOrder.IndicationComment;
this.TumorNucleiPercentage = testOrder.TumorNucleiPercentage;
this.Comment = testOrder.Comment;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder brafV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
brafV600EKTestOrder.Indication = testOrder.Indication;
brafV600EKTestOrder.IndicationComment = testOrder.IndicationComment;
brafV600EKTestOrder.TumorNucleiPercentage = testOrder.TumorNucleiPercentage;
brafV600EKTestOrder.Comment = testOrder.Comment;
}
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Comment:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Comment, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimem: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.References, document, "F");
this.AddNextObxElement("", document, "F");
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
else
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if (patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_LSEIHCIsOrdered = true;
if (this.m_PanelSetOrderSurgical.MasterAccessionNo == patientHistoryResult.MasterAccessionNo)
{
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
else
{
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
}
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_SurgicalSpecimenCollection = new YellowstonePathology.Business.Test.Surgical.SurgicalSpecimenCollection();
foreach (YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder in accessionOrder.SpecimenOrderCollection)
{
YellowstonePathology.Business.Test.Surgical.SurgicalSpecimen surgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(specimenOrder.SpecimenOrderId);
if (surgicalSpecimen != null)
{
this.m_SurgicalSpecimenCollection.Add(surgicalSpecimen);
}
}
this.m_PanelSetOrderLynchSyndromeIHCCollection = new Collection <LynchSyndrome.PanelSetOrderLynchSyndromeIHC>();
this.m_MolecularTestOrderCollection = new PanelSetOrderCollection();
foreach (YellowstonePathology.Business.Test.PanelSetOrder panelSetOrder in accessionOrder.PanelSetOrderCollection)
{
if (panelSetOrder is YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)
{
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add((YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)panelSetOrder);
}
else
{
if (panelSetOrder is LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis ||
panelSetOrder is KRASStandard.KRASStandardTestOrder ||
panelSetOrder is KRASExon23Mutation.KRASExon23MutationTestOrder ||
panelSetOrder is KRASExon4Mutation.KRASExon4MutationTestOrder ||
panelSetOrder is BRAFV600EK.BRAFV600EKTestOrder ||
panelSetOrder is NRASMutationAnalysis.NRASMutationAnalysisTestOrder ||
panelSetOrder is RASRAFPanel.RASRAFPanelTestOrder)
{
this.m_MolecularTestOrderCollection.Add(panelSetOrder);
}
}
}
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == false)
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if (patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add(m_PanelSetOrderLynchSyndromeIHC);
}
}
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrder = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(106);
this.AddCompanyHeader(document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Lynch Syndrome Evaluation", document);
this.AddNextNteElement("Master Accession #: " + panelSetOrder.MasterAccessionNo, document);
this.AddNextNteElement("Report #: " + panelSetOrder.ReportNo, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Interpretation: ", document);
this.HandleLongString(panelSetOrder.Interpretation, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Comment: ", document);
this.HandleLongString(panelSetOrder.Comment, document);
this.AddBlankNteElement(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextNteElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document);
this.AddNextNteElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document);
this.AddNextNteElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document);
this.AddNextNteElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document);
this.AddNextNteElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document);
this.AddBlankNteElement(document);
}
if (panelSetOrder.BRAFIsIndicated == true)
{
this.AddNextNteElement("Molecular Analysis", document);
this.AddBlankNteElement(document);
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
this.AddNextNteElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document);
this.AddNextNteElement("Result: " + panelSetOrderBraf.Result, document);
this.AddBlankNteElement(document);
}
}
this.AddNextNteElement("Method: ", document);
this.HandleLongString(panelSetOrder.Method, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("References: ", document);
this.HandleLongString(panelSetOrder.References, document);
this.AddBlankNteElement(document);
}
public override void Render()
{
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.6.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_PanelSetOrder;
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
base.ReplaceText("report_comment", panelSetOrderLynchSyndromeEvaluation.Comment);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
molecularTestCount += 1;
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.References);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
this.SaveReport();
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Mismatch Repair (MMR)/Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Result:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Result, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
LynchSyndromeIHCPanelTest lynchSyndromeIHCPanelTest = new LynchSyndromeIHCPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (((this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true) &&
panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true) ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true)
{
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderRASRAF.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderRASRAF.BRAFResult, document, "F");
this.AddNextObxElement("", document, "F");
}
}
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("MLH1 Methylation Analysis: " + panelSetOrderMLH1MethylationAnalysis.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderMLH1MethylationAnalysis.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimen: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.ReportReferences, document, "F");
this.AddNextObxElement("", document, "F");
string asr = "This test was developed and its performance characteristics determined by Yellowstone Pathology Institute, Inc. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.";
this.AddNextObxElement(asr, document, "F");
this.AddNextObxElement("", document, "F");
LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
string peformedAtLocation = this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList);
this.HandleLongString(peformedAtLocation, document, "F");
this.AddNextObxElement("", document, "F");
}
public virtual void UnacceptResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder)
{
YellowstonePathology.Business.Test.PanelOrder acceptedPanelOrder = panelSetOrder.PanelOrderCollection.GetLastAcceptedPanelOrder();
acceptedPanelOrder.UnacceptResults();
panelSetOrder.Unaccept();
}
public virtual void UnacceptResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder)
{
panelSetOrder.Unaccept();
}
public virtual void AcceptResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder, YellowstonePathology.Business.Test.PanelOrder panelToAccept, YellowstonePathology.Business.User.SystemIdentity systemIdentity)
{
panelSetOrder.Accept();
}
public virtual void UnFinalizeResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder)
{
panelSetOrder.AssignedToId = 0;
panelSetOrder.Unfinalize();
}
public virtual void FinalizeResults(YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrder, Business.Test.AccessionOrder accessionOrder)
{
panelSetOrder.Finish(accessionOrder);
panelSetOrder.AssignedToId = Business.User.SystemIdentity.Instance.User.UserId;
}
public static KRASStandardReflexResult GetResult(string reportNo, YellowstonePathology.Business.Test.AccessionOrder accessionOrder)
{
KRASStandardReflexResult result = null;
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder krasStandardReflexTestOrder = (YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest krasStandardTest = new KRASStandard.KRASStandardTest();
YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder krasStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(krasStandardTest.PanelSetId, krasStandardReflexTestOrder.OrderedOnId, true);
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, krasStandardReflexTestOrder.OrderedOnId, true) == false)
{
result = new KRASStandardReflexKRASOnlyResult(reportNo, accessionOrder);
}
else
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder brafV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, krasStandardReflexTestOrder.OrderedOnId, true);
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKNotDetectedResult brafV600EKNotDetectedResult = new BRAFV600EK.BRAFV600EKNotDetectedResult();
YellowstonePathology.Business.Test.KRASStandard.KRASStandardNotDetectedResult krasStandardNotDetectedResult = new KRASStandard.KRASStandardNotDetectedResult();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKDetectedResult brafV600EKDetectedResult = new BRAFV600EK.BRAFV600EKDetectedResult();
if (krasStandardTestOrder.ResultCode == krasStandardNotDetectedResult.ResultCode &&
brafV600EKTestOrder.ResultCode == brafV600EKNotDetectedResult.ResultCode)
{
result = new KRASStandardReflexBothNotDetectedResult(reportNo, accessionOrder);
}
else if (krasStandardTestOrder.ResultCode == krasStandardNotDetectedResult.ResultCode &&
brafV600EKTestOrder.ResultCode == brafV600EKDetectedResult.ResultCode)
{
result = new KRASStandardReflexKRASNotDetecedBRAFDetectedResult(reportNo, accessionOrder);
}
else
{
result = new KRASStandardReflexKRASWithBRAFResult(reportNo, accessionOrder);
}
}
return(result);
}
public override void Render()
{
Business.Test.LynchSyndrome.LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.2.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Amendment.Model.AmendmentCollection amendmentCollection = this.m_AccessionOrder.AmendmentCollection.GetAmendmentsForReport(m_PanelSetOrder.ReportNo);
this.SetAmendments(amendmentCollection);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_PanelSetOrder;
base.ReplaceText("report_result", panelSetOrderLynchSyndromeEvaluation.Result);
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.SetXmlNodeData("date_time_collected", collectionDateTimeString);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTest brafMutationAnlaysis = new BRAFMutationAnalysis.BRAFMutationAnalysisTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafMutationAnlaysis.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafMutationAnlaysis.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderRASRAF.BRAFResult);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.ReportReferences);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
base.ReplaceText("summary_location_performed", this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList));
this.SaveReport();
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
else
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if(patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if(accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_SurgicalSpecimenCollection = new YellowstonePathology.Business.Test.Surgical.SurgicalSpecimenCollection();
foreach (YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder in accessionOrder.SpecimenOrderCollection)
{
YellowstonePathology.Business.Test.Surgical.SurgicalSpecimen surgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(specimenOrder.SpecimenOrderId);
if (surgicalSpecimen != null)
{
this.m_SurgicalSpecimenCollection.Add(surgicalSpecimen);
}
}
this.m_PanelSetOrderLynchSyndromeIHCCollection = new Collection<LynchSyndrome.PanelSetOrderLynchSyndromeIHC>();
this.m_MolecularTestOrderCollection = new PanelSetOrderCollection();
foreach(YellowstonePathology.Business.Test.PanelSetOrder panelSetOrder in accessionOrder.PanelSetOrderCollection)
{
if(panelSetOrder is YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)
{
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add((YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)panelSetOrder);
}
else
{
if(panelSetOrder is LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis ||
panelSetOrder is KRASStandard.KRASStandardTestOrder ||
panelSetOrder is KRASExon23Mutation.KRASExon23MutationTestOrder ||
panelSetOrder is KRASExon4Mutation.KRASExon4MutationTestOrder ||
panelSetOrder is BRAFV600EK.BRAFV600EKTestOrder ||
panelSetOrder is NRASMutationAnalysis.NRASMutationAnalysisTestOrder ||
panelSetOrder is RASRAFPanel.RASRAFPanelTestOrder)
{
this.m_MolecularTestOrderCollection.Add(panelSetOrder);
}
}
}
}
public static YellowstonePathology.Business.Rules.MethodResult IsOkToFinal(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder brafv600ekTestOrder)
{
YellowstonePathology.Business.Rules.MethodResult result = brafv600ekTestOrder.IsOkToFinalize();
if (result.Success == true)
{
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest krasStandardReflexTest = new KRASStandardReflex.KRASStandardReflexTest();
if (accessionOrder.PanelSetOrderCollection.Exists(krasStandardReflexTest.PanelSetId, brafv600ekTestOrder.OrderedOnId, true) == false)
{
if (string.IsNullOrEmpty(brafv600ekTestOrder.TumorNucleiPercentage) == true)
{
result.Success = false;
result.Message = "This case cannot be finalized because the Tumor Nuclei Percent is not set.";
}
}
else if (string.IsNullOrEmpty(brafv600ekTestOrder.Result) == true)
{
result.Success = false;
result.Message = "We are unable to finalize this case because the result is blank.";
}
}
return(result);
}
public static LSEResult GetResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromEvaluation)
{
LSEResult result = new LSEResult();
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId);
if (panelSetOrderLynchSyndromeIHC != null)
{
panelSetOrderLynchSyndromeIHC.SetSummaryResult(result);
}
if (panelSetOrderLynchSyndromEvaluation.BRAFIsIndicated == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderBraf.SetSummaryResult(result);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderMLH1MethylationAnalysis.SetSummaryResult(result);
}
return(result);
}
public void UpdateFromChildren(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder testOrder)
{
this.Indication = testOrder.Indication;
this.IndicationComment = testOrder.IndicationComment;
this.TumorNucleiPercentage = testOrder.TumorNucleiPercentage;
this.Comment = testOrder.Comment;
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if(accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
}