private void updateLipophilicityReferences(SystemicProcess systemicProcess, string parameterName)
{
var parameter = systemicProcess.Parameter(parameterName);
if (parameter == null)
{
return;
}
foreach (var objectPath in parameter.Formula.ObjectPaths)
{
objectPath.Replace(ConverterConstants.Parameter.Lipophilicity, CoreConstants.Parameter.LIPOPHILICITY_EXPERIMENT);
}
}
public override void GlobalContext()
{
base.GlobalContext();
_processGFR = _cloneManager.Clone(_compoundProcessRepository.ProcessByName(CoreConstantsForSpecs.Process.GLOMERULAR_FILTRATION).DowncastTo <SystemicProcess>());
_processGFR.Name = "My GFR Process";
_processGFR.Parameter(CoreConstants.Parameters.GFR_FRACTION).Value = 0.8;
_compound.AddProcess(_processGFR);
_simulation = DomainFactoryForSpecs.CreateModelLessSimulationWith(_individual, _compound, _protocol).DowncastTo <IndividualSimulation>();
_simulation.CompoundPropertiesList.First()
.Processes
.TransportAndExcretionSelection
.AddSystemicProcessSelection(new SystemicProcessSelection {
ProcessName = _processGFR.Name, ProcessType = _processGFR.SystemicProcessType
});
DomainFactoryForSpecs.AddModelToSimulation(_simulation);
}
public override void GlobalContext()
{
base.GlobalContext();
_kidneyProcess = _cloneManager.Clone(_compoundProcessRepository.ProcessByName(CoreConstants.Process.KIDNEY_CLEARANCE).DowncastTo <SystemicProcess>());
_kidneyProcess.Name = "My Kidney Process";
_kidneyProcess.Parameter(ConverterConstants.Parameter.PlasmaClearance).Value = 10;
_compound.AddProcess(_kidneyProcess);
_simulation = DomainFactoryForSpecs.CreateModelLessSimulationWith(_individual, _compound, _protocol).DowncastTo <IndividualSimulation>();
_simulation.CompoundPropertiesList.First()
.Processes
.TransportAndExcretionSelection
.AddSystemicProcessSelection(new SystemicProcessSelection {
ProcessName = _kidneyProcess.Name, ProcessType = _kidneyProcess.SystemicProcessType
});
DomainFactoryForSpecs.AddModelToSimulation(_simulation);
}
public override void GlobalContext()
{
base.GlobalContext();
_process = _cloneManager.Clone(_compoundProcessRepository.ProcessByName(ProcessName).DowncastTo <SystemicProcess>());
_process.Name = "My Liver Process";
_process.Parameter(ConverterConstants.Parameter.CLspec).Value = 1;
_compound.AddProcess(_process);
_simulation = DomainFactoryForSpecs.CreateModelLessSimulationWith(_individual, _compound, _protocol).DowncastTo <IndividualSimulation>();
_simulation.CompoundPropertiesFor(_compound.Name)
.Processes
.MetabolizationSelection
.AddSystemicProcessSelection(new SystemicProcessSelection {
ProcessName = _process.Name, ProcessType = _process.SystemicProcessType
});
DomainFactoryForSpecs.AddModelToSimulation(_simulation);
}
public void the_created_simulation_should_have_a_kdiney_GFR_clearance_process_created_based_on_the_one_defined_in_the_compound()
{
var allProcessParameters = _parameterGroupTask.ParametersInTopGroup(CoreConstants.Groups.COMPOUND_PROCESSES, _simulation.All <IParameter>());
allProcessParameters.Select(x => x.ParentContainer.Name).Distinct().ShouldOnlyContain(_processGFR.Name);
allProcessParameters.FindByName(CoreConstants.Parameters.GFR_FRACTION).Value.ShouldBeEqualTo(_processGFR.Parameter(CoreConstants.Parameters.GFR_FRACTION).Value);
}
protected void CheckProcess()
{
var allProcessParameters = _parameterGroupTask.ParametersInTopGroup(CoreConstants.Groups.COMPOUND_PROCESSES, _simulation.All <IParameter>()).ToList();
allProcessParameters.Select(x => x.ParentContainer.Name).Distinct().ShouldOnlyContain(CoreConstants.CompositeNameFor(_compound.Name, _process.Name));
allProcessParameters.FindByName(ConverterConstants.Parameter.CLspec).Value.ShouldBeEqualTo(_process.Parameter(ConverterConstants.Parameter.CLspec).Value);
}
public void the_created_simulation_should_have_a_biliary_clearance_process_created_based_on_the_one_defined_in_the_compound()
{
var allProcessParameters = _parameterGroupTask.ParametersInTopGroup(CoreConstants.Groups.COMPOUND_PROCESSES, _simulation.All <IParameter>()).ToList();
allProcessParameters.Select(x => x.ParentContainer.Name).Distinct().ShouldOnlyContain(CoreConstants.CompositeNameFor(_compound.Name, _liverClearance.Name));
allProcessParameters.FindByName(ConverterConstants.Parameter.PlasmaClearance).Value.ShouldBeEqualTo(_liverClearance.Parameter(ConverterConstants.Parameter.PlasmaClearance).Value);
}