예제 #1
0
        /// <summary>
        /// create a VCF header from a set of header record lines
        /// </summary>
        /// <param name="headerStrings"> a list of strings that represent all the ## and # entries </param>
        /// <returns> a VCFHeader object </returns>
        protected internal virtual VCFHeader parseHeaderFromLines(IList <string> headerStrings, VCFHeaderVersion version)
        {
            this.version = version;
            ISet <VCFHeaderLine> metaData    = new LinkedHashSet <VCFHeaderLine> ();
            ISet <string>        sampleNames = new LinkedHashSet <string> ();
            int contigCounter = 0;

            // iterate over all the passed in strings
            foreach (string str in headerStrings)
            {
                if (!str.StartsWith(VCFHeader.METADATA_INDICATOR))                   //presumably the #CHROM POS ID REF ALT QUAL FILTER INFO   etc. line
                {
                    string[] strings = str.Substring(1).Split(VCFConstants.FIELD_SEPARATOR_CHAR);
                    //check for null last string, grrr...
                    if (String.IsNullOrEmpty(strings.Last()))
                    {
                        strings = strings.Take(strings.Length - 1).ToArray();
                    }
                    if (strings.Length < VCFHeader.HEADER_FIELDS.Length)
                    {
                        throw new VCFParsingError("There are not enough columns present in the header line: " + str);
                    }
                    //Verify Arrays
                    var misMatchedColumns = Enumerable.Range(0, VCFHeader.HEADER_FIELDS.Length).Where(x => VCFHeader.HEADER_FIELDS [x] != strings [x]).Select(x => strings [x]).ToArray();
                    if (misMatchedColumns.Length > 0)
                    {
                        throw new VCFParsingError("We were not expecting column name '" + misMatchedColumns [0] + " in that position");
                    }
                    int  arrayIndex   = VCFHeader.HEADER_FIELDS.Length;                 //start after verified columns
                    bool sawFormatTag = false;
                    if (arrayIndex < strings.Length)
                    {
                        if (!strings [arrayIndex].Equals("FORMAT"))
                        {
                            throw new VCFParsingError("we were expecting column name 'FORMAT' but we saw '" + strings [arrayIndex] + "'");
                        }
                        sawFormatTag = true;
                        arrayIndex++;
                    }
                    while (arrayIndex < strings.Length)
                    {
                        sampleNames.Add(strings [arrayIndex++]);
                    }
                    if (sawFormatTag && sampleNames.Count == 0)
                    {
                        throw new VCFParsingError("The FORMAT field was provided but there is no genotype/sample data");
                    }
                }
                else
                {
                    if (str.StartsWith(VCFConstants.INFO_HEADER_START))
                    {
                        VCFInfoHeaderLine info = new VCFInfoHeaderLine(str.Substring(7), version);
                        metaData.Add(info);
                    }
                    else if (str.StartsWith(VCFConstants.FILTER_HEADER_START))
                    {
                        VCFFilterHeaderLine filter = new VCFFilterHeaderLine(str.Substring(9), version);
                        metaData.Add(filter);
                    }
                    else if (str.StartsWith(VCFConstants.FORMAT_HEADER_START))
                    {
                        VCFFormatHeaderLine format = new VCFFormatHeaderLine(str.Substring(9), version);
                        metaData.Add(format);
                    }
                    else if (str.StartsWith(VCFConstants.CONTIG_HEADER_START))
                    {
                        VCFContigHeaderLine contig = new VCFContigHeaderLine(str.Substring(9), version, VCFConstants.CONTIG_HEADER_START.Substring(2), contigCounter++);
                        metaData.Add(contig);
                    }
                    else if (str.StartsWith(VCFConstants.ALT_HEADER_START))
                    {
                        //TODO: Consider giving Alt header lines their own class
                        VCFSimpleHeaderLine alt = new VCFSimpleHeaderLine(str.Substring(6), version, VCFConstants.ALT_HEADER_START.Substring(2), "ID", "Description");
                        metaData.Add(alt);
                    }
                    else
                    {
                        int equals = str.IndexOf("=");
                        if (equals != -1)
                        {
                            metaData.Add(new VCFHeaderLine(str.Substring(2, equals - 2), str.Substring(equals + 1)));
                        }
                    }
                }
            }
            this.header = new VCFHeader(metaData, sampleNames);
            if (doOnTheFlyModifications)
            {
                this.header = VCFStandardHeaderLines.repairStandardHeaderLines(this.header);
            }
            return(this.header);
        }