public static LSEResult GetResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromEvaluation)
{
LSEResult result = new LSEResult();
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId);
if (panelSetOrderLynchSyndromeIHC != null)
{
panelSetOrderLynchSyndromeIHC.SetSummaryResult(result);
}
if (panelSetOrderLynchSyndromEvaluation.BRAFIsIndicated == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderBraf.SetSummaryResult(result);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderMLH1MethylationAnalysis.SetSummaryResult(result);
}
return(result);
}
public override void SetState(YellowstonePathology.Business.Test.AccessionOrder accessionOrder)
{
base.SetState(accessionOrder);
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest krasStandardReflexTest = new YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest();
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId) == true) // || this.m_AccessionOrder.PanelSetOrderCollection.Exists(krasStandardReflexTest.PanelSetId) == true)
{
this.m_HasPanelSetBeenOrdered = true;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetBrafPanelSetOrder();
if (panelSetOrderBraf.Final == true)
{
this.m_IsStepComplete = true;
if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.Detected)
{
this.m_Stop = true;
this.m_IsStepComplete = true;
}
else if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.NotDetected)
{
this.m_NextStep = new LynchMLH1ByPCRStep();
}
}
}
}
public override void SetState(YellowstonePathology.Business.Test.AccessionOrder accessionOrder)
{
base.SetState(accessionOrder);
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest krasStandardReflexTest = new YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest();
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId) == true) // || this.m_AccessionOrder.PanelSetOrderCollection.Exists(krasStandardReflexTest.PanelSetId) == true)
{
this.m_HasPanelSetBeenOrdered = true;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetBrafPanelSetOrder();
if (panelSetOrderBraf.Final == true)
{
this.m_IsStepComplete = true;
if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.Detected)
{
this.m_Stop = true;
this.m_IsStepComplete = true;
}
else if (panelSetOrderBraf.Result == YellowstonePathology.Business.Test.BRAFV600EK.BRAFResult.NotDetected)
{
this.m_NextStep = new LynchMLH1ByPCRStep();
}
}
}
}
protected Rules.MethodResult HasFinalBRAFResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation)
{
Rules.MethodResult result = new Rules.MethodResult();
result.Success = false;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTest brafMutationAnalysisTest = new BRAFMutationAnalysis.BRAFMutationAnalysisTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderBraf.Final == true)
{
result.Success = true;
result.Message = panelSetOrderBraf.GetSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + brafV600EKTest.PanelSetName + " is not final.";
}
}
else if (accessionOrder.PanelSetOrderCollection.Exists(brafMutationAnalysisTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder brafMutationAnalysisTestOrder = (YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafMutationAnalysisTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (brafMutationAnalysisTestOrder.Final == true)
{
result.Success = true;
result.Message = brafMutationAnalysisTestOrder.GetSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + brafMutationAnalysisTest.PanelSetName + " is not final.";
}
}
else if (accessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderRASRAF.Final == true)
{
result.Success = true;
result.Message = panelSetOrderRASRAF.GetBrafSummaryResult();
}
else
{
result.Success = false;
result.Message = "Unable to set results as the " + rasRAFPanelTest.PanelSetName + " is not final.";
}
}
if (result.Success == false && string.IsNullOrEmpty(result.Message) == true)
{
result.Message = "Unable to set results as a BRAF has not been ordered.";
}
return(result);
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrder = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(106);
this.AddCompanyHeader(document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Lynch Syndrome Evaluation", document);
this.AddNextNteElement("Master Accession #: " + panelSetOrder.MasterAccessionNo, document);
this.AddNextNteElement("Report #: " + panelSetOrder.ReportNo, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Interpretation: ", document);
this.HandleLongString(panelSetOrder.Interpretation, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Comment: ", document);
this.HandleLongString(panelSetOrder.Comment, document);
this.AddBlankNteElement(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextNteElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document);
this.AddNextNteElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document);
this.AddNextNteElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document);
this.AddNextNteElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document);
this.AddNextNteElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document);
this.AddBlankNteElement(document);
}
if (panelSetOrder.BRAFIsIndicated == true)
{
this.AddNextNteElement("Molecular Analysis", document);
this.AddBlankNteElement(document);
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
this.AddNextNteElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document);
this.AddNextNteElement("Result: " + panelSetOrderBraf.Result, document);
this.AddBlankNteElement(document);
}
}
this.AddNextNteElement("Method: ", document);
this.HandleLongString(panelSetOrder.Method, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("References: ", document);
this.HandleLongString(panelSetOrder.References, document);
this.AddBlankNteElement(document);
}
public KRASStandardReflexResult(string reportNo, Business.Test.AccessionOrder accessionOrder)
{
this.m_AccessionOrder = accessionOrder;
this.m_KRASStandardReflexTest = new KRASStandardReflexTest();
this.m_KRASStandardReflexTestOrder = (YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_KRASStandardTest = new KRASStandard.KRASStandardTest();
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOnId, true);
this.m_BRAFV600EKTest = new BRAFV600EK.BRAFV600EKTest();
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOn, true);
this.m_References = "1. Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(10): 1626-1634. " +
"2. Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007; 67(6): 2643-2648.";
}
public KRASStandardReflexResult(string reportNo, Business.Test.AccessionOrder accessionOrder)
{
this.m_AccessionOrder = accessionOrder;
this.m_KRASStandardReflexTest = new KRASStandardReflexTest();
this.m_KRASStandardReflexTestOrder = (YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(reportNo);
this.m_KRASStandardTest = new KRASStandard.KRASStandardTest();
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOnId, true);
this.m_BRAFV600EKTest = new BRAFV600EK.BRAFV600EKTest();
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, this.m_KRASStandardReflexTestOrder.OrderedOn, true);
this.m_References = "1. Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(10): 1626-1634. " +
"2. Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007; 67(6): 2643-2648.";
}
public YellowstonePathology.Business.Test.PanelSetOrder GetBrafPanelSetOrder()
{
YellowstonePathology.Business.Test.PanelSetOrder panelSetOrder = null;
YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest krasStandardReflexTest = new YellowstonePathology.Business.Test.KRASStandardReflex.KRASStandardReflexTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.PanelSet.Model.PanelSetArupBraf panelSetArupBraf = new YellowstonePathology.Business.PanelSet.Model.PanelSetArupBraf();
foreach (YellowstonePathology.Business.Test.PanelSetOrder item in this)
{
if (item.PanelSetId == krasStandardReflexTest.PanelSetId || item.PanelSetId == brafV600EKTest.PanelSetId || item.PanelSetId == panelSetArupBraf.PanelSetId)
{
panelSetOrder = item;
}
}
return(panelSetOrder);
}
private bool ShowBRAFV600EKResultPage()
{
bool result = false;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, this.m_PanelSetOrder.OrderedOnId, true))
{
result = true;
string reportNo = this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId).ReportNo;
YellowstonePathology.UI.Test.BRAFV600EKResultPath resultPath = new YellowstonePathology.UI.Test.BRAFV600EKResultPath(reportNo,
this.m_AccessionOrder, this.m_PageNavigator, System.Windows.Visibility.Visible, this.m_Window);
resultPath.Finish += new Test.ResultPath.FinishEventHandler(ResultPath_Finish);
resultPath.Back += new BRAFV600EKResultPath.BackEventHandler(ResultPath_Back);
resultPath.Start();
}
return result;
}
private bool ShowBRAFV600EKResultPage()
{
bool result = false;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, this.m_PanelSetOrder.OrderedOnId, true))
{
result = true;
string reportNo = this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId).ReportNo;
YellowstonePathology.UI.Test.BRAFV600EKResultPath resultPath = new YellowstonePathology.UI.Test.BRAFV600EKResultPath(reportNo,
this.m_AccessionOrder, this.m_PageNavigator, System.Windows.Visibility.Visible, this.m_Window);
resultPath.Finish += new Test.ResultPath.FinishEventHandler(ResultPath_Finish);
resultPath.Back += new BRAFV600EKResultPath.BackEventHandler(ResultPath_Back);
resultPath.Start();
}
return(result);
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrder = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(106);
this.AddCompanyHeader(document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Lynch Syndrome Evaluation", document);
this.AddNextNteElement("Master Accession #: " + panelSetOrder.MasterAccessionNo, document);
this.AddNextNteElement("Report #: " + panelSetOrder.ReportNo, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Interpretation: ", document);
this.HandleLongString(panelSetOrder.Interpretation, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("Comment: ", document);
this.HandleLongString(panelSetOrder.Comment, document);
this.AddBlankNteElement(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextNteElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document);
this.AddNextNteElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document);
this.AddNextNteElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document);
this.AddNextNteElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document);
this.AddNextNteElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document);
this.AddBlankNteElement(document);
}
if (panelSetOrder.BRAFIsIndicated == true)
{
this.AddNextNteElement("Molecular Analysis", document);
this.AddBlankNteElement(document);
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
this.AddNextNteElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document);
this.AddNextNteElement("Result: " + panelSetOrderBraf.Result, document);
this.AddBlankNteElement(document);
}
}
this.AddNextNteElement("Method: ", document);
this.HandleLongString(panelSetOrder.Method, document);
this.AddBlankNteElement(document);
this.AddNextNteElement("References: ", document);
this.HandleLongString(panelSetOrder.References, document);
this.AddBlankNteElement(document);
}
public static LSEResult GetResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder, YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromEvaluation)
{
LSEResult result = new LSEResult();
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null) panelSetOrderLynchSyndromeIHC.SetSummaryResult(result);
if (panelSetOrderLynchSyndromEvaluation.BRAFIsIndicated == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderBraf.SetSummaryResult(result);
}
else if(accessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderRASRAF.SetBrafSummaryResult(result);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromEvaluation.OrderedOnId, true);
panelSetOrderMLH1MethylationAnalysis.SetSummaryResult(result);
}
return result;
}
public override void Render()
{
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.6.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_PanelSetOrder;
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
base.ReplaceText("report_comment", panelSetOrderLynchSyndromeEvaluation.Comment);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
molecularTestCount += 1;
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.References);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
this.SaveReport();
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Comment:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Comment, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimem: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.References, document, "F");
this.AddNextObxElement("", document, "F");
}
private void LynchSyndromeEvaluationResultPage_OrderBraf(object sender, EventArgs e)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
this.StartReportOrderPath(brafV600EKTest);
this.m_PanelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated = true;
}
public override void Render()
{
Business.Test.LynchSyndrome.LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.8.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation)this.m_PanelSetOrder;
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
base.ReplaceText("report_comment", panelSetOrderLynchSyndromeEvaluation.Comment);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.SetXmlNodeData("date_time_collected", collectionDateTimeString);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
base.ReplaceText("braf_result", panelSetOrderRASRAF.BRAFResult);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.ReportReferences);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
base.ReplaceText("summary_location_performed", this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList));
this.SaveReport();
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
else
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if (patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_LSEIHCIsOrdered = true;
if (this.m_PanelSetOrderSurgical.MasterAccessionNo == patientHistoryResult.MasterAccessionNo)
{
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
else
{
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
}
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_SurgicalSpecimenCollection = new YellowstonePathology.Business.Test.Surgical.SurgicalSpecimenCollection();
foreach (YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder in accessionOrder.SpecimenOrderCollection)
{
YellowstonePathology.Business.Test.Surgical.SurgicalSpecimen surgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(specimenOrder.SpecimenOrderId);
if (surgicalSpecimen != null)
{
this.m_SurgicalSpecimenCollection.Add(surgicalSpecimen);
}
}
this.m_PanelSetOrderLynchSyndromeIHCCollection = new Collection <LynchSyndrome.PanelSetOrderLynchSyndromeIHC>();
this.m_MolecularTestOrderCollection = new PanelSetOrderCollection();
foreach (YellowstonePathology.Business.Test.PanelSetOrder panelSetOrder in accessionOrder.PanelSetOrderCollection)
{
if (panelSetOrder is YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)
{
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add((YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)panelSetOrder);
}
else
{
if (panelSetOrder is LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis ||
panelSetOrder is KRASStandard.KRASStandardTestOrder ||
panelSetOrder is KRASExon23Mutation.KRASExon23MutationTestOrder ||
panelSetOrder is KRASExon4Mutation.KRASExon4MutationTestOrder ||
panelSetOrder is BRAFV600EK.BRAFV600EKTestOrder ||
panelSetOrder is NRASMutationAnalysis.NRASMutationAnalysisTestOrder ||
panelSetOrder is RASRAFPanel.RASRAFPanelTestOrder)
{
this.m_MolecularTestOrderCollection.Add(panelSetOrder);
}
}
}
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == false)
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if (patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add(m_PanelSetOrderLynchSyndromeIHC);
}
}
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Comment:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Comment, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimem: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.References, document, "F");
this.AddNextObxElement("", document, "F");
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
}
private void LynchSyndromeEvaluationResultPage_OrderBraf(object sender, EventArgs e)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
this.StartReportOrderPath(brafV600EKTest);
this.m_PanelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated = true;
}
public override void Render()
{
Business.Test.LynchSyndrome.LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.2.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Amendment.Model.AmendmentCollection amendmentCollection = this.m_AccessionOrder.AmendmentCollection.GetAmendmentsForReport(m_PanelSetOrder.ReportNo);
this.SetAmendments(amendmentCollection);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_PanelSetOrder;
base.ReplaceText("report_result", panelSetOrderLynchSyndromeEvaluation.Result);
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
string collectionDateTimeString = YellowstonePathology.Business.Helper.DateTimeExtensions.CombineDateAndTime(specimenOrder.CollectionDate, specimenOrder.CollectionTime);
this.SetXmlNodeData("date_time_collected", collectionDateTimeString);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTest brafMutationAnlaysis = new BRAFMutationAnalysis.BRAFMutationAnalysisTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafMutationAnlaysis.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFMutationAnalysis.BRAFMutationAnalysisTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafMutationAnlaysis.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
base.ReplaceText("braf_result", panelSetOrderRASRAF.BRAFResult);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.ReportReferences);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
base.ReplaceText("summary_location_performed", this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList));
this.SaveReport();
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if(accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Mismatch Repair (MMR)/Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Result:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Result, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
LynchSyndromeIHCPanelTest lynchSyndromeIHCPanelTest = new LynchSyndromeIHCPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (((this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true) &&
panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true) ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.ReflexToBRAFMeth == true)
{
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, false);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderRASRAF.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderRASRAF.BRAFResult, document, "F");
this.AddNextObxElement("", document, "F");
}
}
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis) this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("MLH1 Methylation Analysis: " + panelSetOrderMLH1MethylationAnalysis.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderMLH1MethylationAnalysis.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimen: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.ReportReferences, document, "F");
this.AddNextObxElement("", document, "F");
string asr = "This test was developed and its performance characteristics determined by Yellowstone Pathology Institute, Inc. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.";
this.AddNextObxElement(asr, document, "F");
this.AddNextObxElement("", document, "F");
LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
string peformedAtLocation = this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList);
this.HandleLongString(peformedAtLocation, document, "F");
this.AddNextObxElement("", document, "F");
}
public LynchBRAFStep()
{
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
}
private void ResultPage_OrderBRAF(object sender, EventArgs e)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
this.StartReportOrderPath(brafV600EKTest);
}
public override void ToXml(XElement document)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_ReportNo);
this.AddHeader(document, panelSetOrderLynchSyndromeEvaluation, "Lynch Syndrome Evaluation");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Interpretation:", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Interpretation, document, "F");
this.AddNextObxElement("", document, "F");
this.HandleLongString("Comment:", document, "F");
this.AddNextObxElement(panelSetOrderLynchSyndromeEvaluation.Comment, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Pathologist: " + panelSetOrderLynchSyndromeEvaluation.Signature, document, "F");
if (panelSetOrderLynchSyndromeEvaluation.FinalTime.HasValue == true)
{
this.AddNextObxElement("E-signed " + panelSetOrderLynchSyndromeEvaluation.FinalTime.Value.ToString("MM/dd/yyyy HH:mm"), document, "F");
}
this.AddNextObxElement("", document, "F");
this.AddAmendments(document);
LynchSyndromeIHCPanelTest lynchSyndromeIHCPanelTest = new LynchSyndromeIHCPanelTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(lynchSyndromeIHCPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("Mismatch Repair Protein Expression by Immunohistochemistry: ", document, "F");
this.AddNextObxElement("MLH1: " + panelSetOrderLynchSyndromeIHC.MLH1Result, document, "F");
this.AddNextObxElement("MSH2: " + panelSetOrderLynchSyndromeIHC.MSH2Result, document, "F");
this.AddNextObxElement("MSH6: " + panelSetOrderLynchSyndromeIHC.MSH6Result, document, "F");
this.AddNextObxElement("PMS2: " + panelSetOrderLynchSyndromeIHC.PMS2Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest rasRAFPanelTest = new YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTest();
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (((this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true) &&
panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true) ||
this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
this.AddNextObxElement("Molecular Analysis", document, "F");
this.AddNextObxElement("", document, "F");
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderBraf.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderBraf.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
else if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder panelSetOrderRASRAF = (YellowstonePathology.Business.Test.RASRAFPanel.RASRAFPanelTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(rasRAFPanelTest.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("BRAF V600E Mutation by PCR: " + panelSetOrderRASRAF.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderRASRAF.BRAFResult, document, "F");
this.AddNextObxElement("", document, "F");
}
}
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true) == true)
{
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, panelSetOrderLynchSyndromeEvaluation.OrderedOnId, true);
this.AddNextObxElement("MLH1 Methylation Analysis: " + panelSetOrderMLH1MethylationAnalysis.ReportNo, document, "F");
this.AddNextObxElement("Result: " + panelSetOrderMLH1MethylationAnalysis.Result, document, "F");
this.AddNextObxElement("", document, "F");
}
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.AddNextObxElement("Specimen: " + specimenOrder.Description, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("Method: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.Method, document, "F");
this.AddNextObxElement("", document, "F");
this.AddNextObxElement("References: ", document, "F");
this.HandleLongString(panelSetOrderLynchSyndromeEvaluation.ReportReferences, document, "F");
this.AddNextObxElement("", document, "F");
string asr = "This test was developed and its performance characteristics determined by Yellowstone Pathology Institute, Inc. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.";
this.AddNextObxElement(asr, document, "F");
this.AddNextObxElement("", document, "F");
LynchSyndromeEvaluationTest lynchSyndromeEvaluationTest = new LynchSyndromeEvaluationTest();
string peformedAtLocation = this.m_AccessionOrder.PanelSetOrderCollection.GetLocationPerformedSummary(lynchSyndromeEvaluationTest.PanelSetIDList);
this.HandleLongString(peformedAtLocation, document, "F");
this.AddNextObxElement("", document, "F");
}
private void ResultPage_OrderBRAF(object sender, EventArgs e)
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
this.StartReportOrderPath(brafV600EKTest);
}
public ComprehensiveColonCancerProfileResult(YellowstonePathology.Business.Test.AccessionOrder accessionOrder,
ComprehensiveColonCancerProfile comprehensiveColonCancerProfile)
{
this.m_SpecimenOrder = accessionOrder.SpecimenOrderCollection.GetSpecimenOrderByOrderTarget(comprehensiveColonCancerProfile.OrderedOnId);
this.m_PanelSetOrderSurgical = (YellowstonePathology.Business.Test.Surgical.SurgicalTestOrder)accessionOrder.PanelSetOrderCollection.GetSurgical();
this.m_SurgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(this.m_SpecimenOrder.SpecimenOrderId);
bool restrictToOrderedOn = !comprehensiveColonCancerProfile.IncludeTestsPerformedOnOtherBlocks;
YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest panelSetLynchSyndromeIHCPanel = new YellowstonePathology.Business.Test.LynchSyndrome.LynchSyndromeIHCPanelTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
else
{
YellowstonePathology.Business.Domain.PatientHistory patientHistory = YellowstonePathology.Business.Gateway.AccessionOrderGateway.GetPatientHistory(accessionOrder.PatientId);
if(patientHistory.PanelSetIdExists(102) == true)
{
YellowstonePathology.Business.Domain.PatientHistoryResult patientHistoryResult = patientHistory.GetByPanelSetId(102);
YellowstonePathology.Business.Test.AccessionOrder lseIHCAccessionOrder = Business.Persistence.DocumentGateway.Instance.GetAccessionOrderByMasterAccessionNo(patientHistoryResult.MasterAccessionNo);
this.m_LSEIHCIsOrdered = true;
this.m_PanelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)lseIHCAccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetLynchSyndromeIHCPanel.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
this.m_IHCResult = YellowstonePathology.Business.Test.LynchSyndrome.IHCResult.CreateResultFromResultCode(this.m_PanelSetOrderLynchSyndromeIHC.ResultCode);
}
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_MLHIsOrdered = true;
this.m_PanelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_BRAFV600EKIsOrdered = true;
this.m_BRAFV600EKTestOrder = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_BRAFV600EKTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASStandardTest = new YellowstonePathology.Business.Test.KRASStandard.KRASStandardTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASStandardIsOrdered = true;
this.m_KRASStandardTestOrder = (YellowstonePathology.Business.Test.KRASStandard.KRASStandardTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASStandardTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon23MutationTest = new KRASExon23Mutation.KRASExon23MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon23MutationIsOrdered = true;
this.m_KRASExon23MutationTestOrder = (KRASExon23Mutation.KRASExon23MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon23MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_KRASExon4MutationTest = new KRASExon4Mutation.KRASExon4MutationTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_KRASExon4MutationIsOrdered = true;
this.m_KRASExon4MutationTestOrder = (KRASExon4Mutation.KRASExon4MutationTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_KRASExon4MutationTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_NRASMutationAnalysisTest = new NRASMutationAnalysis.NRASMutationAnalysisTest();
if (accessionOrder.PanelSetOrderCollection.Exists(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_NRASMutationAnalysisIsOrdered = true;
this.m_NRASMutationAnalysisTestOrder = (NRASMutationAnalysis.NRASMutationAnalysisTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_NRASMutationAnalysisTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_RASRAFPanelTest = new RASRAFPanel.RASRAFPanelTest();
if(accessionOrder.PanelSetOrderCollection.Exists(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn) == true)
{
this.m_RASRAFIsOrdered = true;
this.m_RASRAFPanelTestOrder = (RASRAFPanel.RASRAFPanelTestOrder)accessionOrder.PanelSetOrderCollection.GetPanelSetOrder(this.m_RASRAFPanelTest.PanelSetId, comprehensiveColonCancerProfile.OrderedOnId, restrictToOrderedOn);
}
this.m_SurgicalSpecimenCollection = new YellowstonePathology.Business.Test.Surgical.SurgicalSpecimenCollection();
foreach (YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder in accessionOrder.SpecimenOrderCollection)
{
YellowstonePathology.Business.Test.Surgical.SurgicalSpecimen surgicalSpecimen = this.m_PanelSetOrderSurgical.SurgicalSpecimenCollection.GetBySpecimenOrderId(specimenOrder.SpecimenOrderId);
if (surgicalSpecimen != null)
{
this.m_SurgicalSpecimenCollection.Add(surgicalSpecimen);
}
}
this.m_PanelSetOrderLynchSyndromeIHCCollection = new Collection<LynchSyndrome.PanelSetOrderLynchSyndromeIHC>();
this.m_MolecularTestOrderCollection = new PanelSetOrderCollection();
foreach(YellowstonePathology.Business.Test.PanelSetOrder panelSetOrder in accessionOrder.PanelSetOrderCollection)
{
if(panelSetOrder is YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)
{
this.m_PanelSetOrderLynchSyndromeIHCCollection.Add((YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)panelSetOrder);
}
else
{
if(panelSetOrder is LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis ||
panelSetOrder is KRASStandard.KRASStandardTestOrder ||
panelSetOrder is KRASExon23Mutation.KRASExon23MutationTestOrder ||
panelSetOrder is KRASExon4Mutation.KRASExon4MutationTestOrder ||
panelSetOrder is BRAFV600EK.BRAFV600EKTestOrder ||
panelSetOrder is NRASMutationAnalysis.NRASMutationAnalysisTestOrder ||
panelSetOrder is RASRAFPanel.RASRAFPanelTestOrder)
{
this.m_MolecularTestOrderCollection.Add(panelSetOrder);
}
}
}
}
public override void Render()
{
int molecularTestCount = 0;
this.m_TemplateName = @"\\CFileServer\Documents\ReportTemplates\XmlTemplates\LynchSyndromeEvaluation.6.xml";
this.OpenTemplate();
this.SetDemographicsV2();
this.SetReportDistribution();
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation panelSetOrderLynchSyndromeEvaluation = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeEvaluation)this.m_PanelSetOrder;
base.ReplaceText("report_interpretation", panelSetOrderLynchSyndromeEvaluation.Interpretation);
base.ReplaceText("report_comment", panelSetOrderLynchSyndromeEvaluation.Comment);
YellowstonePathology.Business.Specimen.Model.SpecimenOrder specimenOrder = this.m_AccessionOrder.SpecimenOrderCollection.GetSpecimenOrder(panelSetOrderLynchSyndromeEvaluation.OrderedOn, panelSetOrderLynchSyndromeEvaluation.OrderedOnId);
this.ReplaceText("specimen_description", specimenOrder.Description);
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC panelSetOrderLynchSyndromeIHC = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderLynchSyndromeIHC)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(102);
if (panelSetOrderLynchSyndromeIHC != null)
{
base.ReplaceText("mlh1_result", panelSetOrderLynchSyndromeIHC.MLH1Result);
base.ReplaceText("msh2_result", panelSetOrderLynchSyndromeIHC.MSH2Result);
base.ReplaceText("msh6_result", panelSetOrderLynchSyndromeIHC.MSH6Result);
base.ReplaceText("pms2_result", panelSetOrderLynchSyndromeIHC.PMS2Result);
}
if (panelSetOrderLynchSyndromeEvaluation.BRAFIsIndicated == true)
{
molecularTestCount += 1;
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(18) == true) //BRAF
{
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest brafV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder panelSetOrderBraf = (YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTestOrder)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(brafV600EKTest.PanelSetId);
base.ReplaceText("braf_result", panelSetOrderBraf.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
}
else
{
this.DeleteRow("braf_result");
}
YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest panelSetMLH1 = new YellowstonePathology.Business.Test.LynchSyndrome.MLH1MethylationAnalysisTest();
if (this.m_AccessionOrder.PanelSetOrderCollection.Exists(panelSetMLH1.PanelSetId) == true)
{
molecularTestCount += 1;
YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis panelSetOrderMLH1MethylationAnalysis = (YellowstonePathology.Business.Test.LynchSyndrome.PanelSetOrderMLH1MethylationAnalysis)this.m_AccessionOrder.PanelSetOrderCollection.GetPanelSetOrder(panelSetMLH1.PanelSetId);
base.ReplaceText("mlh1methylation_result", panelSetOrderMLH1MethylationAnalysis.Result);
base.ReplaceText("molecular_analysis_header", "Molecular Analysis");
}
else
{
this.DeleteRow("mlh1methylation_result");
}
if (molecularTestCount == 0)
{
this.DeleteRow("molecular_analysis_header");
}
base.ReplaceText("report_references", panelSetOrderLynchSyndromeEvaluation.References);
base.ReplaceText("report_method", panelSetOrderLynchSyndromeEvaluation.Method);
base.ReplaceText("pathologist_signature", panelSetOrderLynchSyndromeEvaluation.Signature);
this.SaveReport();
}
public LynchBRAFStep()
{
this.m_BRAFV600EKTest = new YellowstonePathology.Business.Test.BRAFV600EK.BRAFV600EKTest();
}
