protected override Task Context() { _solverSettingsMapper = A.Fake <SolverSettingsMapper>(); _outputSchemaMapper = A.Fake <OutputSchemaMapper>(); _outputSelectionMapper = A.Fake <OutputSelectionsMapper>(); _parameterMapper = A.Fake <ParameterMapper>(); _compoundPropertiesMapper = A.Fake <CompoundPropertiesMapper>(); _advancedParameterMapper = A.Fake <AdvancedParameterMapper>(); _eventMappingMapper = A.Fake <EventMappingMapper>(); _observerSetMappingMapper = A.Fake <ObserverSetMappingMapper>(); _curveChartMapper = A.Fake <SimulationTimeProfileChartMapper>(); _processMappingMapper = A.Fake <ProcessMappingMapper>(); _simulationFactory = A.Fake <ISimulationFactory>(); _executionContext = A.Fake <IExecutionContext>(); _simulationModelCreator = A.Fake <ISimulationModelCreator>(); _simulationBuildingBlockUpdater = A.Fake <ISimulationBuildingBlockUpdater>(); _modelPropertiesTask = A.Fake <IModelPropertiesTask>(); _simulationRunner = A.Fake <ISimulationRunner>(); _populationAnalysisChartMapper = A.Fake <PopulationAnalysisChartMapper>(); _simulationParameterOriginIdUpdater = A.Fake <ISimulationParameterOriginIdUpdater>(); _logger = A.Fake <ILogger>(); _containerTask = A.Fake <IContainerTask>(); _entityPathResolver = A.Fake <IEntityPathResolver>(); sut = new SimulationMapper(_solverSettingsMapper, _outputSchemaMapper, _outputSelectionMapper, _compoundPropertiesMapper, _parameterMapper, _advancedParameterMapper, _eventMappingMapper, _observerSetMappingMapper, _curveChartMapper, _populationAnalysisChartMapper, _processMappingMapper, _simulationFactory, _executionContext, _simulationModelCreator, _simulationBuildingBlockUpdater, _modelPropertiesTask, _simulationRunner, _simulationParameterOriginIdUpdater, _logger, _containerTask, _entityPathResolver ); _project = new PKSimProject(); _individual = new Individual { Name = "IND", Id = "IND" }; _compound = new Compound { Name = "COMP", Id = "COMP" }; _observerSet = new ObserverSet { Name = "OBS_SET", Id = "OBS_SET" }; _protocol = new SimpleProtocol { Name = "PROT", Id = "PROT" }; _inductionProcess = new InductionProcess().WithName("Interaction process"); _compound.AddProcess(_inductionProcess); _event = new PKSimEvent { Name = "Event" }; _population = new RandomPopulation() { Name = "POP" }; _observedData = new DataRepository("OBS_ID").WithName("OBS"); _project.AddBuildingBlock(_individual); _project.AddBuildingBlock(_compound); _project.AddBuildingBlock(_event); _project.AddBuildingBlock(_population); _project.AddBuildingBlock(_observerSet); _project.AddObservedData(_observedData); _simulationProperties = new SimulationProperties { ModelProperties = new ModelProperties { ModelConfiguration = new ModelConfiguration { ModelName = "4Comp" } } }; _interactionSelection = new InteractionSelection { ProcessName = _inductionProcess.Name }; _noInteractionSelection = new InteractionSelection { MoleculeName = "CYP2D6" }; _simulationProperties.InteractionProperties.AddInteraction(_interactionSelection); _simulationProperties.InteractionProperties.AddInteraction(_noInteractionSelection); _settings = new SimulationSettings(); _rootContainer = new Container().WithName("Sim"); _model = new OSPSuite.Core.Domain.Model { Root = _rootContainer }; _individualSimulation = new IndividualSimulation { Name = "S1", Properties = _simulationProperties, SimulationSettings = _settings, Description = "Simulation Description", Model = _model }; _simulationTimeProfile = new SimulationTimeProfileChart(); _snapshotSimulationTimeProfile = new CurveChart(); _individualSimulation.AddAnalysis(_simulationTimeProfile); A.CallTo(() => _curveChartMapper.MapToSnapshot(_simulationTimeProfile)).Returns(_snapshotSimulationTimeProfile); _populationSimulation = new PopulationSimulation { Properties = _simulationProperties, SimulationSettings = _settings, Model = _model }; _advancedParameterCollection = new AdvancedParameterCollection(); _populationSimulationAnalysisChart = new BoxWhiskerAnalysisChart(); _populationSimulation.SetAdvancedParameters(_advancedParameterCollection); _populationSimulation.AddAnalysis(_populationSimulationAnalysisChart); _populationSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndTemplateId", PKSimBuildingBlockType.Individual) { BuildingBlock = _individual }); _snapshotPopulationAnalysisChart = new Snapshots.PopulationAnalysisChart(); A.CallTo(() => _populationAnalysisChartMapper.MapToSnapshot(_populationSimulationAnalysisChart)).Returns(_snapshotPopulationAnalysisChart); _snapshotInteraction = new CompoundProcessSelection(); A.CallTo(() => _processMappingMapper.MapToSnapshot(_interactionSelection)).Returns(_snapshotInteraction); _snapshotInteraction.CompoundName = _compound.Name; _snapshotInteraction.Name = _inductionProcess.Name; _noSelectionSnapshotInteraction = new CompoundProcessSelection(); A.CallTo(() => _processMappingMapper.MapToSnapshot(_noInteractionSelection)).Returns(_noSelectionSnapshotInteraction); _noSelectionSnapshotInteraction.MoleculeName = _noInteractionSelection.MoleculeName; _compoundProperties = new CompoundProperties(); _snapshotCompoundProperties = new Snapshots.CompoundProperties { Name = _compound.Name }; _individualSimulation.Properties.AddCompoundProperties(_compoundProperties); _eventMapping = new EventMapping(); _individualSimulation.EventProperties.AddEventMapping(_eventMapping); _observerSetMapping = new ObserverSetMapping(); _individualSimulation.ObserverSetProperties.AddObserverSetMapping(_observerSetMapping); A.CallTo(() => _compoundPropertiesMapper.MapToSnapshot(_compoundProperties, _project)).Returns(_snapshotCompoundProperties); _eventSelection = new EventSelection { Name = _event.Name, }; _observerSetSelection = new ObserverSetSelection { Name = _observerSet.Name, }; _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndTemplateId", PKSimBuildingBlockType.Individual) { BuildingBlock = _individual, Altered = true }); _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompTemplateId", PKSimBuildingBlockType.Compound) { BuildingBlock = _compound }); _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("ProtTemplateId", PKSimBuildingBlockType.Protocol) { BuildingBlock = _protocol }); _individualSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("ObserveSetTemplateId", PKSimBuildingBlockType.ObserverSet) { BuildingBlock = _observerSet }); _populationSimulation.AddUsedBuildingBlock(new UsedBuildingBlock("PopTemplateId", PKSimBuildingBlockType.Population) { BuildingBlock = _population }); _individualSimulation.AddUsedObservedData(_observedData); A.CallTo(() => _eventMappingMapper.MapToSnapshot(_eventMapping, _project)).Returns(_eventSelection); A.CallTo(() => _observerSetMappingMapper.MapToSnapshot(_observerSetMapping, _project)).Returns(_observerSetSelection); _outputSelectionSnapshot = new OutputSelections(); A.CallTo(() => _outputSelectionMapper.MapToSnapshot(_individualSimulation.OutputSelections)).Returns(_outputSelectionSnapshot); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotInteraction, _inductionProcess)).Returns(_interactionSelection); return(_completed); }
protected override Task Context() { _calculationMethodCacheMapper = A.Fake <CalculationMethodCacheMapper>(); _processMappingMapper = A.Fake <ProcessMappingMapper>(); _logger = A.Fake <ILogger>(); _project = new PKSimProject(); _calculationMethodSnapshot = new CalculationMethodCache(); sut = new CompoundPropertiesMapper(_calculationMethodCacheMapper, _processMappingMapper, _logger); _compoundGroupSelectionOneAlternative = new CompoundGroupSelection { AlternativeName = "ALT1", GroupName = "ALTERNATIVE_GROUP_1" }; _compoundGroupSelectionTwoAlternatives = new CompoundGroupSelection { AlternativeName = "ALT2", GroupName = "ALTERNATIVE_GROUP_2" }; _compound = new Compound { Name = "COMP", }; _protocol = new SimpleProtocol { Name = "PROTOCOL" }; _parameterAlternativeGroupWithOneAlternative = new ParameterAlternativeGroup { Name = _compoundGroupSelectionOneAlternative.GroupName }; _parameterAlternativeGroupWithTwoAlternatives = new ParameterAlternativeGroup { Name = _compoundGroupSelectionTwoAlternatives.GroupName }; _parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative { Name = "ALT1" }); _parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative { Name = "ALT2" }); _compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithOneAlternative); _compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithTwoAlternatives); _compoundProperties = new Model.CompoundProperties(); _compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionOneAlternative); _compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionTwoAlternatives); _compoundProperties.Compound = _compound; _enzymaticProcess = new EnzymaticProcess { Name = "EnzymaticProcess" }; _anotherEnzymaticProcess = new EnzymaticProcess { Name = "AnotherEnzymaticProcess", MoleculeName = "CYP3A4" }; _specificBindingProcess = new SpecificBindingPartialProcess { Name = "SpecificBinding" }; _gfrTransportProcess = new SystemicProcess { Name = "Transport", SystemicProcessType = SystemicProcessTypes.GFR }; _hepaticEnzymaticProcess = new SystemicProcess { Name = "Plasma Clearance", SystemicProcessType = SystemicProcessTypes.Hepatic }; _compound.AddProcess(_enzymaticProcess); _compound.AddProcess(_specificBindingProcess); _compound.AddProcess(_gfrTransportProcess); _compound.AddProcess(_hepaticEnzymaticProcess); _enzymaticPartialProcessSelection = new EnzymaticProcessSelection { ProcessName = _enzymaticProcess.Name }; _noEnzymaticSystemicProcessSelection = new SystemicProcessSelection { ProcessType = SystemicProcessTypes.Hepatic }; _specificBindingPartialProcessSelection = new ProcessSelection { ProcessName = _specificBindingProcess.Name }; _transportSystemicProcessSelection = new SystemicProcessSelection { ProcessName = _gfrTransportProcess.Name, ProcessType = _gfrTransportProcess.SystemicProcessType, }; _noEnzymaticPartialProcessSelection = new EnzymaticProcessSelection { MoleculeName = _anotherEnzymaticProcess.MoleculeName }; _compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_enzymaticPartialProcessSelection); _compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_noEnzymaticPartialProcessSelection); _compoundProperties.Processes.MetabolizationSelection.AddSystemicProcessSelection(_noEnzymaticSystemicProcessSelection); _compoundProperties.Processes.SpecificBindingSelection.AddPartialProcessSelection(_specificBindingPartialProcessSelection); _compoundProperties.Processes.TransportAndExcretionSelection.AddSystemicProcessSelection(_transportSystemicProcessSelection); _snapshotProcess1 = new CompoundProcessSelection { Name = _enzymaticPartialProcessSelection.ProcessName }; _snapshotProcess2 = new CompoundProcessSelection { Name = _specificBindingPartialProcessSelection.ProcessName }; _snapshotProcess3 = new CompoundProcessSelection { Name = _transportSystemicProcessSelection.ProcessName }; _snapshotProcess4 = new CompoundProcessSelection { SystemicProcessType = _noEnzymaticSystemicProcessSelection.ProcessType.SystemicProcessTypeId.ToString() }; _snapshotProcess5 = new CompoundProcessSelection { MoleculeName = _noEnzymaticPartialProcessSelection.MoleculeName }; _formulation = new Formulation { Id = "123456" }; _compoundProperties.ProtocolProperties.Protocol = _protocol; _compoundProperties.ProtocolProperties.AddFormulationMapping(new FormulationMapping { FormulationKey = "F1", TemplateFormulationId = _formulation.Id }); _project.AddBuildingBlock(_formulation); A.CallTo(() => _calculationMethodCacheMapper.MapToSnapshot(_compoundProperties.CalculationMethodCache)).Returns(_calculationMethodSnapshot); A.CallTo(() => _processMappingMapper.MapToSnapshot(_enzymaticPartialProcessSelection)).Returns(_snapshotProcess1); A.CallTo(() => _processMappingMapper.MapToSnapshot(_specificBindingPartialProcessSelection)).Returns(_snapshotProcess2); A.CallTo(() => _processMappingMapper.MapToSnapshot(_transportSystemicProcessSelection)).Returns(_snapshotProcess3); A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticSystemicProcessSelection)).Returns(_snapshotProcess4); A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticPartialProcessSelection)).Returns(_snapshotProcess5); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess1, _enzymaticProcess)).Returns(_enzymaticPartialProcessSelection); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess2, _specificBindingProcess)).Returns(_specificBindingPartialProcessSelection); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess3, _gfrTransportProcess)).Returns(_transportSystemicProcessSelection); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess4, A <NotSelectedSystemicProcess> ._)).Returns(_noEnzymaticSystemicProcessSelection); A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess5, A <EnzymaticProcess> ._)).Returns(_noEnzymaticPartialProcessSelection); return(_completed); }