protected override void Context()
{
base.Context();
_ddiRatioSimulation = new IndividualSimulation();
//Simulate calculated results by setting the DataRepository
_ddiRatioSimulation.DataRepository = _simulation.DataRepository;
_pkAnalysis = new PKAnalysis();
_pkAnalysis.Add(DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(Constants.PKParameters.C_max));
_pkAnalysis.Add(DomainHelperForSpecs.ConstantParameterWithValue(2).WithName(Constants.PKParameters.AUC_inf));
A.CallTo(() => _globalPKAnalysisRunner.RunForDDIRatio(_simulation)).Returns(_ddiRatioSimulation);
A.CallTo(() => _pkAnalysisTask.CalculateFor(_ddiRatioSimulation, _peripheralVenousBloodPlasma)).Returns(new IndividualPKAnalysis(_peripheralVenousBloodPlasma, _pkAnalysis));
}
protected override void Context()
{
base.Context();
//Simulate calculated results by setting the DataRepository
_aucIVSimulation = new IndividualSimulation {
DataRepository = _simulation.DataRepository
};
_pkAnalysis = new PKAnalysis();
_pkAnalysis.Add(DomainHelperForSpecs.ConstantParameterWithValue(2).WithName(Constants.PKParameters.AUC_inf));
A.CallTo(() => _globalPKAnalysisRunner.RunForBioavailability(_protocol, _simulation, _compound)).Returns(_aucIVSimulation);
A.CallTo(() => _pkAnalysisTask.CalculateFor(_aucIVSimulation, _venousBloodPlasma)).Returns(new IndividualPKAnalysis(_venousBloodPlasma, _pkAnalysis));
A.CallTo(() => _protocolFactory.Create(ProtocolMode.Simple, ApplicationTypes.Intravenous)).Returns(_protocol);
_protocol.AddParameter(DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(Constants.Parameters.INFUSION_TIME));
_protocol.AddParameter(DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(CoreConstants.Parameters.INPUT_DOSE));
_protocol.AddParameter(DomainHelperForSpecs.ConstantParameterWithValue(1).WithName(Constants.Parameters.START_TIME));
//single dosing
var schemaItem = A.Fake <SchemaItem>();
var inputDose = DomainHelperForSpecs.ConstantParameterWithValue(10);
var startTime = DomainHelperForSpecs.ConstantParameterWithValue(3);
A.CallTo(() => schemaItem.Dose).Returns(inputDose);
A.CallTo(() => schemaItem.StartTime).Returns(startTime);
_simulationSchemaItems.Add(schemaItem);
}
public PKAnalysis MapFrom(DataColumn dataColumn, PKValues pkValues, PKParameterMode mode, string moleculeName)
{
var pk = new PKAnalysis().WithName(moleculeName);
_pkParameterRepository.All().Where(parameter => parameter.Mode.Is(mode)).Each(parameter => pk.Add(createPKParameter(parameter, pkValues)));
pk.MolWeight = dataColumn.DataInfo.MolWeight;
return(pk);
}