//!!!Yikes tons of repeated code and stuff re-run internal static HlaAssignmentWithResponses CreateHlaAssignment(Quickscore <Hla, int> quickscore, string hlaListAsString, ICollection <int> patientsWhoRespond) { Qmrr.HlaFactory hlaFactory = Qmrr.HlaFactory.GetFactory("noConstraint"); //!!!this code is repeated elsewhere Dictionary <Hla, List <int> > hlaToRespondingPatientsUnfiltered = quickscore.CreateCauseToSubsetOfEffects(patientsWhoRespond); Dictionary <Hla, List <int> > hlaToRespondingPatients = Filter9xs(hlaToRespondingPatientsUnfiltered); List <Hla> hlaListFromRepondingPatients = new List <Hla>(hlaToRespondingPatients.Keys); Dictionary <Hla, bool> hlaAssignmentDicationary = new Dictionary <Hla, bool>(); foreach (string hlaName in hlaListAsString.Split(';')) { Hla hla = hlaFactory.GetGroundInstance(hlaName); hlaAssignmentDicationary[hla] = true; } List <int> indexCollection = new List <int>(); for (int hlaIndex = 0; hlaIndex < hlaListFromRepondingPatients.Count; ++hlaIndex) { Hla hla = hlaListFromRepondingPatients[hlaIndex]; if (hlaAssignmentDicationary.ContainsKey(hla)) { indexCollection.Add(hlaIndex); } } HlaAssignmentWithResponses hlaAssignment = HlaAssignmentWithResponses.GetInstance(quickscore, hlaListFromRepondingPatients, indexCollection, hlaToRespondingPatients); return(hlaAssignment); }
internal static HlaAssignmentWithResponses GetInstance(Quickscore <Hla, int> quickscore, List <Hla> hlaListFromRepondingPatients, List <int> indexCollection, Dictionary <Hla, List <int> > hlaToRespondingPatients) { List <Hla> trueCollection = new List <Hla>(); foreach (int index in indexCollection) { Hla hla = hlaListFromRepondingPatients[index]; trueCollection.Add(hla); } return(HlaAssignmentWithResponses.GetInstance(trueCollection, quickscore, hlaListFromRepondingPatients, hlaToRespondingPatients)); }
public static bool BetterAtExplainingReactions(HlaAssignmentWithResponses champ, HlaAssignmentWithResponses challenger) { if (challenger.UnexplainedPatients.Count < champ.UnexplainedPatients.Count) { return(true); } if (champ.UnexplainedPatients.Count < challenger.UnexplainedPatients.Count) { return(false); } return(challenger.TrueCount < champ.TrueCount); }
//private Dictionary<string, bool> GetAList(Dictionary<string, string> row) //{ // Dictionary<string, bool> alist = new Dictionary<string, bool>(); // string alistValue = row["HLA In Fixed List"]; // foreach (string hla in alistValue.Split(' ')) // { // Debug.Assert((hla.Length == 3 && !hla.StartsWith("B15")) || (hla.Length == 5 && hla.StartsWith("B15"))); // alist.Add(hla, true); // } // return alist; //} public static HlaAssignmentWithResponses CreateHlaAssignment(List <Dictionary <string, string> > rowsOfThisPeptide, IEnumerable <Hla> hlaList, HlaResolution hlaResolution, Quickscore <Hla, int> quickscore, List <int> patientsWhoRespond) { //!!!this code is repeated elsewhere Dictionary <Hla, List <int> > hlaToRespondingPatientsUnfiltered = quickscore.CreateCauseToSubsetOfEffects(patientsWhoRespond); Dictionary <Hla, List <int> > hlaToRespondingPatients = Filter9xs(hlaToRespondingPatientsUnfiltered); List <Hla> hlaListFromRepondingPatients = new List <Hla>(hlaToRespondingPatients.Keys); Dictionary <Hla, bool> hlaAssignmentDicationary = new Dictionary <Hla, bool>(); foreach (Dictionary <string, string> causeAssignmentRow in rowsOfThisPeptide) { Hla hla = GetHlaFromRow(causeAssignmentRow, hlaResolution); hlaAssignmentDicationary[hla] = true; } HlaAssignmentWithResponses hlaAssignment = HlaAssignmentWithResponses.GetInstance(hlaAssignmentDicationary.Keys, quickscore, hlaListFromRepondingPatients, hlaToRespondingPatients); return(hlaAssignment); }
internal static HlaAssignmentWithResponses GetInstance(IEnumerable <Hla> trueCollection, Quickscore <Hla, int> quickscore, List <Hla> hlaListFromRepondingPatients, Dictionary <Hla, List <int> > hlaToRespondingPatients) { HlaAssignmentWithResponses aHlaAssignment = new HlaAssignmentWithResponses(); aHlaAssignment.TrueCollection = TrueCollection.GetInstance(trueCollection); aHlaAssignment.AsDictionary = new Dictionary <Hla, bool>(); aHlaAssignment.UnexplainedPatients = new List <int>(); Dictionary <int, bool> patientToIsExplained = new Dictionary <int, bool>(); aHlaAssignment.HlaToRespondingPatients = hlaToRespondingPatients; foreach (Hla hla in trueCollection) { aHlaAssignment.AsDictionary.Add(hla, true); foreach (int patient in hlaToRespondingPatients[hla]) { patientToIsExplained[patient] = true; } } foreach (Hla hla in quickscore.CauseList()) { if (!aHlaAssignment.AsDictionary.ContainsKey(hla)) { aHlaAssignment.AsDictionary.Add(hla, false); if (hlaToRespondingPatients.ContainsKey(hla)) { foreach (int patient in hlaToRespondingPatients[hla]) { if (!patientToIsExplained.ContainsKey(patient)) { patientToIsExplained.Add(patient, false); aHlaAssignment.UnexplainedPatients.Add(patient); } } } } } return(aHlaAssignment); }
//!!!Yikes tons of repeated code and stuff re-run public static HlaAssignmentWithResponses CreateHlaAssignment(List <Dictionary <string, string> > rowsOfThisPeptide, IEnumerable <Hla> hlaList, HlaResolution hlaResolution, Quickscore <Hla, int> quickscore, List <int> patientsWhoRespond, Hla hlaToReplace, Hla hlaWithWhichToReplaceItOrNull) { //!!!this code is repeated elsewhere Dictionary <Hla, List <int> > hlaToRespondingPatientsUnfiltered = quickscore.CreateCauseToSubsetOfEffects(patientsWhoRespond); Dictionary <Hla, List <int> > hlaToRespondingPatients = Filter9xs(hlaToRespondingPatientsUnfiltered); List <Hla> hlaListFromRepondingPatients = new List <Hla>(hlaToRespondingPatients.Keys); Dictionary <Hla, bool> hlaAssignmentDicationary = new Dictionary <Hla, bool>(); foreach (Dictionary <string, string> causeAssignmentRow in rowsOfThisPeptide) { Hla hla = GetHlaFromRow(causeAssignmentRow, hlaResolution); hlaAssignmentDicationary[hla] = true; } hlaAssignmentDicationary.Remove(hlaToReplace); if (hlaWithWhichToReplaceItOrNull != null) { hlaAssignmentDicationary.Add(hlaWithWhichToReplaceItOrNull, true); } List <int> indexCollection = new List <int>(); for (int hlaIndex = 0; hlaIndex < hlaListFromRepondingPatients.Count; ++hlaIndex) { Hla hla = hlaListFromRepondingPatients[hlaIndex]; if (hlaAssignmentDicationary.ContainsKey(hla)) { indexCollection.Add(hlaIndex); } } HlaAssignmentWithResponses hlaAssignment = HlaAssignmentWithResponses.GetInstance(quickscore, hlaListFromRepondingPatients, indexCollection, hlaToRespondingPatients); return(hlaAssignment); }
public static void SearchHlaAssignmentsRelaxation(string fileName, string header, string solutionFileName, string solutionHeader, double causePrior, double linkProbability, double leakProbability, int howManyBest, string outputFilename, HlaResolution hlaResolution) { Debug.Assert(Math.Exp(double.NegativeInfinity) == 0); //Create the structure of patients and their HLAs Quickscore <Hla, int> quickscore = HlaAssignmentParams.CreateQuickscore(fileName, header, causePrior, linkProbability, leakProbability, hlaResolution); // Get the list of patients, Hlas, and patient weights List <int> patientList = quickscore.EffectList(); IEnumerable <Hla> hlaList = quickscore.CauseList(); //The structure file can contain a "weight" column. If it does, weight the patients, otherwise give them all weight 1.0 Dictionary <int, double> patientWeightTable = HlaAssignmentParams.CreatePatientWeightTable(fileName, header); //The cause assignment table is a mapping from // peptide to HLA assignments for that peptide Dictionary <string, List <Dictionary <string, string> > > causeAssignmentTable = CreateCauseAssignmentTable(solutionFileName, solutionHeader); //We start the report using (StreamWriter streamwriterOutputFile = File.CreateText(outputFilename)) { //The report is the same as the input "solution" except that we now list new HLA, a note, and a p(assignment) streamwriterOutputFile.WriteLine(SpecialFunctions.CreateTabString(solutionHeader, "newHLA", "rank", "p(assignment)", "note", "Peptide", "LogLikelihood", "TrueHlas.Count", "TrueHlas", "TrueHlasAndRespondingPatients", "UnexplainedPatients.Count")); //Now we go through the model file, one peptide at a time. For each peptide, we know the patientID (did) of // every patient who responded. (It also tells the HLAs of the patient, but we already have that info in the structure) /* * peptide did a1 a2 b1 b2 c1 c2 * * ACQGVGGPGHK 10 2 11 38 44 12 16 * ACQGVGGPGHK 14 2 24 1517 58 3 7 * ACQGVGGPGHK 41 11 33 35 40 6 7 * ACQGVGGPGHK 102 2 11 35 44 4 5 * * AENLWVTVY 25 24 66 35 39 4 12 * AENLWVTVY 36 23 32 8 44 7 7 * AENLWVTVY 45 3 31 39 44 5 12 * AENLWVTVY 46 2 29 41 52 16 16 * AENLWVTVY 59 2 33 7 44 3 15 * * [...] */ foreach (List <Dictionary <string, string> > tableByPeptide in HlaAssignmentParams.QuickScoreOptimalsGroupByPeptide(fileName, header)) { Debug.Assert(tableByPeptide.Count > 0); // real assert string peptide = tableByPeptide[0]["peptide"]; //Create lists of patients who responded and assume everyone else didn't. List <int> patientsWhoRespond; List <int> patientsWhoDoNotRespond; FindPatientsWhoRespondAndWhoDoNot(patientList, tableByPeptide, out patientsWhoRespond, out patientsWhoDoNotRespond); //If we get a peptide with no row in the solution file, skip it. if (!causeAssignmentTable.ContainsKey(peptide)) { streamwriterOutputFile.WriteLine("{0}\t\t{1}", peptide, "explained by noise"); continue; } //We assign every HLA mentioned by the solution file with this peptide to TRUE and all others to FALSE //An assignment of TRUE means that this HLA is a cause of this response. List <Dictionary <string, string> > rowsOfThisPeptide = causeAssignmentTable[peptide]; HlaAssignmentWithResponses hlaAssignmentBase = CreateHlaAssignment(rowsOfThisPeptide, hlaList, hlaResolution, quickscore, patientsWhoRespond); //Find the likelihood of this structure, with these patient responses, and the solution's HLA assignment. double baseLogLikelihood = quickscore.LogLikelihoodOfModelWithCompleteAssignments(patientsWhoRespond, patientsWhoDoNotRespond, hlaAssignmentBase.AsDictionary, patientWeightTable); //Consider each HLA assigned to TRUE (for this peptide) by the solution foreach (Dictionary <string, string> row in rowsOfThisPeptide) { Hla hla = GetHlaFromRow(row, hlaResolution); //If we already really know that this HLA is a cause of this reponse, just report that. if (IsKnown(row)) { streamwriterOutputFile.WriteLine("{0}\t{1}\t{2}", row[""], hla, "known"); continue; } //Set it to false as a way to see measure the probability that it is true. HlaAssignmentWithResponses hlaAssignmentL0 = CreateHlaAssignment(rowsOfThisPeptide, hlaList, hlaResolution, quickscore, patientsWhoRespond, hla, null); double logL0 = quickscore.LogLikelihoodOfModelWithCompleteAssignments(patientsWhoRespond, patientsWhoDoNotRespond, hlaAssignmentL0.AsDictionary, patientWeightTable); Debug.Assert(hlaAssignmentL0.TrueCount + 1 == hlaAssignmentBase.TrueCount); // real assert string noteNote = ""; if (logL0 > baseLogLikelihood) { noteNote = string.Format("\tlogL0 > baseLogLikelihood ({0}>{1})", logL0, baseLogLikelihood); } double probability = Math.Exp(baseLogLikelihood - SpecialFunctions.LogSum(baseLogLikelihood, logL0)); streamwriterOutputFile.WriteLine(SpecialFunctions.CreateTabString( row[""], hla, "1 best", probability, noteNote, peptide, baseLogLikelihood, hlaAssignmentBase.TrueCount, hlaAssignmentBase.TrueToString(), hlaAssignmentBase.TrueToListString(), hlaAssignmentBase.UnexplainedPatients.Count)); streamwriterOutputFile.WriteLine(SpecialFunctions.CreateTabString( row[""], hla, "remove 1 best", "", noteNote, peptide, logL0, hlaAssignmentL0.TrueCount, hlaAssignmentL0.TrueToString(), hlaAssignmentL0.TrueToListString(), hlaAssignmentL0.UnexplainedPatients.Count)); //Also, while we're in the world were it is false, let's measure how well each of the currently-set-to-false HLAs would do instead. //!!!should this be one dictionary to a new class instead of three dictionaries? List <KeyValuePair <Hla, double> > listOfhla1AndProbability1 = new List <KeyValuePair <Hla, double> >(); Dictionary <Hla, double> loglikelihoodCollection = new Dictionary <Hla, double>(); Dictionary <Hla, HlaAssignmentWithResponses> hla1ToHlaAssignment = new Dictionary <Hla, HlaAssignmentWithResponses>(); foreach (Hla hla1 in hlaList) { if (hla1 == hla || hlaAssignmentBase.AsDictionary[hla1]) { continue; } HlaAssignmentWithResponses hlaAssignmentL1 = CreateHlaAssignment(rowsOfThisPeptide, hlaList, hlaResolution, quickscore, patientsWhoRespond, hla, hla1); if (hlaAssignmentL1.TrueCount == hlaAssignmentBase.TrueCount) { double logL1 = quickscore.LogLikelihoodOfModelWithCompleteAssignments(patientsWhoRespond, patientsWhoDoNotRespond, hlaAssignmentL1.AsDictionary, patientWeightTable); double probability1 = Math.Exp(logL1 - SpecialFunctions.LogSum(logL1, logL0)); loglikelihoodCollection[hla1] = logL1; hla1ToHlaAssignment.Add(hla1, hlaAssignmentL1); listOfhla1AndProbability1.Add(new KeyValuePair <Hla, double>(hla1, probability1)); } } //Report on the best of these listOfhla1AndProbability1.Sort(delegate(KeyValuePair <Hla, double> x, KeyValuePair <Hla, double> y) { return(y.Value.CompareTo(x.Value)); }); for (int i = 0; i < howManyBest - 1; ++i) { Hla hla1 = listOfhla1AndProbability1[i].Key; streamwriterOutputFile.WriteLine(SpecialFunctions.CreateTabString( row[""], hla1, string.Format("{0} best", i + 2), listOfhla1AndProbability1[i].Value, "", peptide, loglikelihoodCollection[hla1], hla1ToHlaAssignment[hla1].TrueCount, hla1ToHlaAssignment[hla1].TrueToString(), hla1ToHlaAssignment[hla1].TrueToListString(), hla1ToHlaAssignment[hla1].UnexplainedPatients.Count)); } } } } }