public HAMPatch(HAMPatchParameters p)
{
Ngating = 10;
a = new double[Ngating];
b = new double[Ngating];
y0 = new double[Ngating + 3];
eNa = (R * p.Tk / F) * Math.Log(p.NAo / p.NAi);
eK = (R * p.Tk / F) * Math.Log(p.Ko / p.Ki);
Cm = p.Cm;
Cn = p.Cn;
Ci = p.Ci;
Ril = 1 / p.Gil;
gSL = (1 / Ril) * p.nGsl;
Ko = p.Ko;
Ki = p.Ki;
NAi = p.NAi;
NAo = p.NAo;
Tk = p.Tk;
ClampKo = p.ClampKo;
L = p.L;
// Ionic Currents
p.CopyRateConstants(p.q10m, p.Am, Am);
p.CopyRateConstants(p.q10h, p.Ah, Ah);
p.CopyRateConstants(p.q10p, p.Ap, Ap);
p.CopyRateConstants(p.q10n, p.An, An);
p.CopyRateConstants(p.q10s, p.As, As);
p.CopyRateConstants(p.q10i, p.Ai, Ai);
p.CopyRateConstants(p.q10q, p.Aq, Aq);
p.CopyRateConstants(p.q10u, p.Au, Au);
p.CopyRateConstants(p.q10m, p.Bm, Bm);
p.CopyRateConstants(p.q10h, p.Bh, Bh);
p.CopyRateConstants(p.q10p, p.Bp, Bp);
p.CopyRateConstants(p.q10n, p.Bn, Bn);
p.CopyRateConstants(p.q10s, p.Bs, Bs);
p.CopyRateConstants(p.q10i, p.Bi, Bi);
p.CopyRateConstants(p.q10q, p.Bq, Bq);
p.CopyRateConstants(p.q10u, p.Bu, Bu);
// Conductances
Vi = CircleArea(p.di) * p.L;
Vpa = (CircleArea(p.di + p.Wpa) - CircleArea(p.di)) * p.L;
Apa = p.di * Math.PI * p.L;
gNat_n = (1 - p.pNap_n) * p.gNa_n * p.Area_n;
gNap_n = p.pNap_n * p.gNa_n * p.Area_n;
gKf_n = p.gKf_n * p.Area_n;
gKs_n = p.gKs_n * p.Area_n;
gKi_n = p.gKi_n * p.Area_n;
gLk_n = p.gLk_n * p.Area_n;
gKs_i = p.gKs_i * p.Area_i;
gKi_i = p.gKi_i * p.Area_i;
gH_Na_i = p.gH_i * p.Area_i * p.gH_SNa;
gH_K_i = p.gH_i * p.Area_i * (1 - p.gH_SNa);
gLk_i = p.gLk_i * p.Area_i;
// Calculate inter-nodal resting potential
En = y0[0] = p.Vr;
Ei = y0[1] = p.Vi;
y0[2] = Ko;
SetupGatingVariables();
double Rbb = getRbb(y0);
iPump_n = -(Iion_n(y0) - (Ei - En) / Rbb);
//Ei = y0[1] = Ril * Iion_n(y0) + p.Vr;
// Calculate inter-nodal leak conductance
SetupGatingVariables();
iPump_i = -Iion_i(y0) - (y0[1] - y0[0]) / Rbb;
// Calculate the value of the sodium potassium pump that will keep the
// potassium concentration of the peri-axonal space stable at rest
Km_K = p.Km_K;
Km_Na = p.Km_Na;
L_K = p.L_K;
L_Na = p.L_Na;
Jmax = 1;
// We now calculate the Jmax that will keep the peri-axonal potassium
// concentration stable at rest.
double Jk_pa = jK_i(y0);
Jmax = -Jk_pa / jPump(y0);
}
public HAMPatch(HAMPatchParameters p)
{
Ngating = 10;
a = new double[Ngating];
b = new double[Ngating];
y0 = new double[Ngating + 3];
eNa = (R*p.Tk / F) * Math.Log(p.NAo / p.NAi);
eK = (R*p.Tk / F) * Math.Log(p.Ko / p.Ki);
Cm = p.Cm;
Cn = p.Cn;
Ci = p.Ci;
Ril = 1/p.Gil;
gSL = (1 / Ril) * p.nGsl;
Ko = p.Ko;
Ki = p.Ki;
NAi = p.NAi;
NAo = p.NAo;
Tk = p.Tk;
ClampKo = p.ClampKo;
L = p.L;
// Ionic Currents
p.CopyRateConstants(p.q10m, p.Am, Am);
p.CopyRateConstants(p.q10h, p.Ah, Ah);
p.CopyRateConstants(p.q10p, p.Ap, Ap);
p.CopyRateConstants(p.q10n, p.An, An);
p.CopyRateConstants(p.q10s, p.As, As);
p.CopyRateConstants(p.q10i, p.Ai, Ai);
p.CopyRateConstants(p.q10q, p.Aq, Aq);
p.CopyRateConstants(p.q10u, p.Au, Au);
p.CopyRateConstants(p.q10m, p.Bm, Bm);
p.CopyRateConstants(p.q10h, p.Bh, Bh);
p.CopyRateConstants(p.q10p, p.Bp, Bp);
p.CopyRateConstants(p.q10n, p.Bn, Bn);
p.CopyRateConstants(p.q10s, p.Bs, Bs);
p.CopyRateConstants(p.q10i, p.Bi, Bi);
p.CopyRateConstants(p.q10q, p.Bq, Bq);
p.CopyRateConstants(p.q10u, p.Bu, Bu);
// Conductances
Vi = CircleArea(p.di) * p.L;
Vpa = (CircleArea(p.di+p.Wpa)-CircleArea(p.di))* p.L;
Apa = p.di * Math.PI * p.L;
gNat_n = (1-p.pNap_n) * p.gNa_n * p.Area_n;
gNap_n = p.pNap_n * p.gNa_n * p.Area_n;
gKf_n = p.gKf_n * p.Area_n;
gKs_n = p.gKs_n * p.Area_n;
gKi_n = p.gKi_n * p.Area_n;
gLk_n = p.gLk_n * p.Area_n;
gKs_i = p.gKs_i * p.Area_i;
gKi_i = p.gKi_i * p.Area_i;
gH_Na_i = p.gH_i * p.Area_i * p.gH_SNa;
gH_K_i = p.gH_i * p.Area_i * (1-p.gH_SNa);
gLk_i = p.gLk_i * p.Area_i;
// Calculate inter-nodal resting potential
En = y0[0] = p.Vr;
Ei = y0[1] = p.Vi;
y0[2] = Ko;
SetupGatingVariables();
double Rbb = getRbb(y0);
iPump_n = -(Iion_n(y0) - (Ei - En) / Rbb);
//Ei = y0[1] = Ril * Iion_n(y0) + p.Vr;
// Calculate inter-nodal leak conductance
SetupGatingVariables();
iPump_i = -Iion_i(y0) - (y0[1]-y0[0])/Rbb;
// Calculate the value of the sodium potassium pump that will keep the
// potassium concentration of the peri-axonal space stable at rest
Km_K = p.Km_K;
Km_Na = p.Km_Na;
L_K = p.L_K;
L_Na = p.L_Na;
Jmax = 1;
// We now calculate the Jmax that will keep the peri-axonal potassium
// concentration stable at rest.
double Jk_pa = jK_i(y0);
Jmax = -Jk_pa / jPump(y0);
}
