private void findPathwayToolStripMenuItem_Click(object sender, EventArgs e)
{
if (CompleteScreening == null) return;
FormForNameRequest FormForRequest = new FormForNameRequest();
if (FormForRequest.ShowDialog() != System.Windows.Forms.DialogResult.OK) return;
int NumberOfPlates = CompleteScreening.ListPlatesActive.Count;
FormForKeggGene KeggWin = new FormForKeggGene();
KEGG ServKegg = new KEGG();
string[] intersection_gene_pathways = new string[1];
string[] Pathways = { FormForRequest.textBoxForName.Text };
intersection_gene_pathways = ServKegg.get_genes_by_pathway("path:" + Pathways[0]);
if ((Pathways == null) || (Pathways.Length == 0))
{
MessageBox.Show("No pathway founded !", "Warning", MessageBoxButtons.OK, MessageBoxIcon.Exclamation);
return;
}
string[] fg_list = { "black" };
string[] bg_list = { "orange" };
string pathway_map_html = "";
// KEGG ServKegg = new KEGG();
string[] ListGenesinPathway = ServKegg.get_genes_by_pathway("path:" + Pathways[0]);
if (ListGenesinPathway.Length == 0)
{
return;
}
double[] ListValues = new double[ListGenesinPathway.Length];
int IDxGeneOfInterest = 0;
foreach (cPlate CurrentPlate in CompleteScreening.ListPlatesActive)
{
foreach (cWell CurrentWell in CurrentPlate.ListActiveWells)
{
string CurrentLID = "hsa:" + (int)CurrentWell.LocusID;
for (int IdxGene = 0; IdxGene < ListGenesinPathway.Length; IdxGene++)
{
if (CurrentLID == intersection_gene_pathways[0])
IDxGeneOfInterest = IdxGene;
if (CurrentLID == ListGenesinPathway[IdxGene])
{
ListValues[IdxGene] = CurrentWell.ListDescriptors[CompleteScreening.ListDescriptors.CurrentSelectedDescriptor].GetValue();
break;
}
}
}
}
bg_list = new string[ListGenesinPathway.Length];
fg_list = new string[ListGenesinPathway.Length];
double MinValue = ListValues.Min();
double MaxValue = ListValues.Max();
for (int IdxCol = 0; IdxCol < bg_list.Length; IdxCol++)
{
int ConvertedValue = (int)((((CompleteScreening.GlobalInfo.LUTs.LUT_GREEN_TO_RED[0].Length - 1) * (ListValues[IdxCol] - MinValue)) / (MaxValue - MinValue)));
Color Coul = Color.FromArgb(CompleteScreening.GlobalInfo.LUTs.LUT_GREEN_TO_RED[0][ConvertedValue], CompleteScreening.GlobalInfo.LUTs.LUT_GREEN_TO_RED[1][ConvertedValue], CompleteScreening.GlobalInfo.LUTs.LUT_GREEN_TO_RED[2][ConvertedValue]);
if (IdxCol == IDxGeneOfInterest)
fg_list[IdxCol] = "white";
else
fg_list[IdxCol] = "#000000";
bg_list[IdxCol] = "#" + Coul.Name.Remove(0, 2);
}
// foreach (string item in ListP.listBoxPathways.SelectedItems)
{
pathway_map_html = ServKegg.get_html_of_colored_pathway_by_objects(Pathways[0], ListGenesinPathway, fg_list, bg_list);
}
pathway_map_html = ServKegg.get_html_of_colored_pathway_by_objects((string)(Pathways[0]), intersection_gene_pathways, fg_list, bg_list);
// FormForKegg KeggWin = new FormForKegg();
if (pathway_map_html.Length == 0) return;
//
//KeggWin.Show();
//ListP.listBoxPathways.MouseDoubleClick += new MouseEventHandler(listBox1_MouseDoubleClick);
KeggWin.webBrowser.Navigate(pathway_map_html);
KeggWin.Show();
}
void listBox1_MouseDoubleClick(object sender, MouseEventArgs e)
{
string[] fg_list = { "black" };
string[] bg_list = { "orange" };
string[] intersection_gene_pathways = new string[1];
intersection_gene_pathways[0] = "hsa:" + LocusID;
string pathway_map_html = "";
KEGG ServKegg = new KEGG();
string[] ListGenesinPathway = ServKegg.get_genes_by_pathway((string)ListP.listBoxPathways.SelectedItem);
double[] ListValues = new double[ListGenesinPathway.Length];
int IDxGeneOfInterest = 0;
foreach (cPlate CurrentPlate in Parent.ListPlatesActive)
{
foreach (cWell CurrentWell in CurrentPlate.ListActiveWells)
{
string CurrentLID = "hsa:" + (int)CurrentWell.LocusID;
for (int IdxGene = 0; IdxGene < ListGenesinPathway.Length; IdxGene++)
{
if (CurrentLID == intersection_gene_pathways[0])
IDxGeneOfInterest = IdxGene;
if (CurrentLID == ListGenesinPathway[IdxGene])
{
ListValues[IdxGene] = CurrentWell.ListDescriptors[Parent.ListDescriptors.CurrentSelectedDescriptor].GetValue();
break;
}
}
}
}
bg_list = new string[ListGenesinPathway.Length];
fg_list = new string[ListGenesinPathway.Length];
double MinValue = ListValues.Min();
double MaxValue = ListValues.Max();
for (int IdxCol = 0; IdxCol < bg_list.Length; IdxCol++)
{
int ConvertedValue = (int)((((Parent.GlobalInfo.LUTs.LUT_JET[0].Length - 1) * (ListValues[IdxCol] - MinValue)) / (MaxValue - MinValue)));
Color Coul = Color.FromArgb(Parent.GlobalInfo.LUTs.LUT_JET[0][ConvertedValue], Parent.GlobalInfo.LUTs.LUT_JET[1][ConvertedValue], Parent.GlobalInfo.LUTs.LUT_JET[2][ConvertedValue]);
if (IdxCol == IDxGeneOfInterest)
fg_list[IdxCol] = "white";
else
fg_list[IdxCol] = "#000000";
bg_list[IdxCol] = "#" + Coul.Name.Remove(0, 2);
}
pathway_map_html = ServKegg.get_html_of_colored_pathway_by_objects((string)ListP.listBoxPathways.SelectedItem, ListGenesinPathway, fg_list, bg_list);
string GenInfo = ServKegg.bget((string)ListP.listBoxPathways.SelectedItem);
string[] Genes = GenInfo.Split(new char[] { '\n' });
string Res = "";
foreach (string item in Genes)
{
string[] fre = item.Split(' ');
string[] STRsection = fre[0].Split('_');
if (STRsection[0] != "NAME") continue;
for (int i = 1; i < fre.Length; i++)
{
if (fre[i] == "") continue;
Res += fre[i] + " ";
}
}
FormForKegg KeggWin = new FormForKegg();
if (pathway_map_html.Length == 0) return;
KeggWin.Text = Res;
KeggWin.Show();
KeggWin.webBrowser.Navigate(pathway_map_html);
}