/// <summary>
/// compare two domain interfaces
/// </summary>
/// <param name="domainInterface1"></param>
/// <param name="domainInterface2"></param>
/// <returns></returns>
public DomainInterfacePairInfo CompareEntryDomainInterfaces(DomainInterface domainInterface1,
DomainInterface domainInterface2)
{
double qScore = qFunc.WeightQFunc(domainInterface1, domainInterface2);
bool interfaceReversed = false;
if (qScore < AppSettings.parameters.simInteractParam.interfaceSimCutoff &&
domainInterface1.familyCode1 == domainInterface2.familyCode2)
{
domainInterface2.Reverse();
double reversedQScore = qFunc.WeightQFunc(domainInterface1, domainInterface2);
if (qScore < reversedQScore)
{
qScore = reversedQScore;
interfaceReversed = true;
}
else
{
domainInterface2.Reverse();
}
}
DomainInterfacePairInfo interfacePairInfo = new DomainInterfacePairInfo
(new DomainInterfaceInfo(domainInterface1), new DomainInterfaceInfo(domainInterface2));
interfacePairInfo.qScore = qScore;
interfacePairInfo.isInterface2Reversed = interfaceReversed;
return(interfacePairInfo);
}
/// <summary>
/// compare two domain interfaces
/// </summary>
/// <param name="domainInterface1"></param>
/// <param name="domainInterface2"></param>
/// <param name="domainAlignInfoTable"></param>
/// <returns></returns>
public DomainInterfacePairInfo CompareTwoDomainInterfaces(DomainInterface domainInterface1,
DomainInterface domainInterface2, DataTable domainAlignInfoTable)
{
DomainInterface domainInterface2Copy = new DomainInterface(domainInterface2, true); // keep a deep copy
double identity = supDomainInterface.SuperposeDomainInterfaces(domainInterface1, domainInterface2Copy, domainAlignInfoTable);
double qScore = qFunc.WeightQFunc(domainInterface1, domainInterface2Copy);
// domainInterface2 = domainInterface2Copy; // shadow copy
// supDomainInterface.ReverseSupDomainInterfaces(domainInterface1, domainInterface2, domainAlignInfoTable);
bool interfaceReversed = false;
if (qScore < AppSettings.parameters.simInteractParam.interfaceSimCutoff &&
domainInterface1.familyCode1 == domainInterface2.familyCode2)
{
domainInterface2Copy = new DomainInterface(domainInterface2, true);
domainInterface2Copy.Reverse();
// keep deep copy
double reversedIdentity =
supDomainInterface.SuperposeDomainInterfaces(domainInterface1, domainInterface2Copy, domainAlignInfoTable);
double reversedQScore = qFunc.WeightQFunc(domainInterface1, domainInterface2Copy);
// domainInterface2 = domainInterface2Copy;
// supDomainInterface.ReverseSupDomainInterfaces(domainInterface1, domainInterface2, domainAlignInfoTable);
if (qScore < reversedQScore)
{
qScore = reversedQScore;
identity = reversedIdentity;
interfaceReversed = true;
}
}
DomainInterfacePairInfo interfacePairInfo = new DomainInterfacePairInfo
(new DomainInterfaceInfo(domainInterface1), new DomainInterfaceInfo(domainInterface2));
interfacePairInfo.qScore = qScore;
if (identity <= 0)
{
interfacePairInfo.identity = -1.0;
}
else
{
interfacePairInfo.identity = identity;
}
interfacePairInfo.isInterface2Reversed = interfaceReversed;
return(interfacePairInfo);
}