private void addPKAnalysisSensitivities(VariationData variationData, SimulationResults simulationResults, SensitivityAnalysisRunResult sensitivityRunResult, SensitivityAnalysis sensitivityAnalysis)
{
var pkAnalyses = _pkAnalysesTask.CalculateFor(sensitivityAnalysis.Simulation, simulationResults);
foreach (var pkParameter in pkAnalyses.All())
{
sensitivityAnalysis.AllSensitivityParameters.Each(sensitivityParameter =>
{
var pkSensitivity = calculatePKParameterSensitivity(sensitivityParameter, variationData, pkParameter);
if (pkSensitivity != null)
{
sensitivityRunResult.AddPKParameterSensitivity(pkSensitivity);
}
});
}
}
protected override void Context()
{
base.Context();
_sensitivityAnalysisRunResult = new SensitivityAnalysisRunResult();
_simulation = A.Fake <IModelCoreSimulation>().WithName("Sim");
var pkParameter = new PKParameterSensitivity
{
QuantityPath = "Liver",
PKParameterName = "AUC",
ParameterName = "P1",
Value = 0.5,
ParameterPath = "ParameterPath"
};
_sensitivityAnalysisRunResult.AddPKParameterSensitivity(pkParameter);
}
public SensitivityAnalysisRunResult CreateFor(SensitivityAnalysis sensitivityAnalysis, VariationData variationData, SimulationResults simulationResults)
{
var sensitivityRunResult = new SensitivityAnalysisRunResult();
var pkAnalyses = _pkAnalysesTask.CalculateFor(sensitivityAnalysis.Simulation, variationData.NumberOfVariations, simulationResults);
foreach (var pkParameter in pkAnalyses.All())
{
sensitivityAnalysis.AllSensitivityParameters.Each((sensitivityParameter, index) =>
{
var pkSensitivity = calculateParameterSensitivity(sensitivityParameter, index, variationData, pkParameter);
if (pkSensitivity != null)
{
sensitivityRunResult.AddPKParameterSensitivity(pkSensitivity);
}
});
}
return(sensitivityRunResult);
}
