private bool isRenalClearance(IPartialProcessMapping compoundProcessMapping)
{
var systemicPocess = compoundProcessMapping as SystemicProcessSelection;
if (systemicPocess == null)
{
return(false);
}
return((systemicPocess.ProcessType == SystemicProcessTypes.Renal) ||
(systemicPocess.ProcessType == SystemicProcessTypes.GFR));
}
private void addTransportProcess(IMoleculeBuilder drug, IPartialProcessMapping compoundProcessMapping, CompoundProperties compoundProperties)
{
var compound = compoundProperties.Compound;
var process = compound.ProcessByName(compoundProcessMapping.ProcessName);
if (isRenalClearance(compoundProcessMapping))
{
var renalPassiveProcess = _processBuilderMapper.PassiveTransportProcessFrom(process, drug.Name, _passiveTransports.FormulaCache);
_passiveTransports.Add(renalPassiveProcess);
_parameterIdUpdater.UpdateBuildingBlockId(renalPassiveProcess.Parameters, compound);
return;
}
var transporter = _individual.MoleculeByName <IndividualTransporter>(compoundProcessMapping.MoleculeName);
var transporterMoleculeContainer = _processBuilderMapper.ActiveTransportFrom(process, transporter, _moleculeBuildingBlock.FormulaCache);
_interactionKineticUpdater.UpdateTransport(transporterMoleculeContainer, compoundProcessMapping.MoleculeName, compound.Name, _simulation, _moleculeBuildingBlock.FormulaCache);
_parameterIdUpdater.UpdateBuildingBlockId(transporterMoleculeContainer.Parameters, compound);
drug.AddTransporterMoleculeContainer(transporterMoleculeContainer);
}
private static SimulationPartialProcess newSimulationPartialProcess <TIndividualMolecule>(TIndividualMolecule individualMolecule, PartialProcess partialProcess, IPartialProcessMapping partialProcessMapping = null)
where TIndividualMolecule : IndividualMolecule
{
return(new SimulationPartialProcess {
CompoundProcess = partialProcess, IndividualMolecule = individualMolecule, PartialProcessMapping = partialProcessMapping
});
}
private static bool isSelected <TPartialProcess>(TPartialProcess compoundProcess, IPartialProcessMapping mapping) where TPartialProcess : PartialProcess
{
return(compoundProcess != null && string.Equals(compoundProcess.ParentCompound.Name, mapping.CompoundName));
}
