public override void GlobalContext()
{
base.GlobalContext();
_compoundProcessRepository = IoC.Resolve <ICompoundProcessRepository>();
_cloneManager = IoC.Resolve <ICloneManager>();
_enzymeFactory = IoC.Resolve <IIndividualEnzymeFactory>();
_transporterFactory = IoC.Resolve <IIndividualTransporterFactory>();
_modelPropertiesTask = IoC.Resolve <IModelPropertiesTask>();
_modelConfigurationRepository = IoC.Resolve <IModelConfigurationRepository>();
_compound = DomainFactoryForSpecs.CreateStandardCompound();
_individual = DomainFactoryForSpecs.CreateStandardIndividual();
_protocol = DomainFactoryForSpecs.CreateStandardIVBolusProtocol();
_enzyme = _enzymeFactory.CreateFor(_individual).DowncastTo <IndividualEnzyme>().WithName("CYP");
_enzyme.GetRelativeExpressionNormParameterFor(CoreConstants.Compartment.Plasma).Value = _relExpNormPls;
_enzyme.GetRelativeExpressionNormParameterFor(CoreConstants.Compartment.BloodCells).Value = _relExpNormBloodCells;
_enzyme.GetRelativeExpressionNormParameterFor(CoreConstants.Compartment.VascularEndothelium).Value = _relExpVascEndo;
_individual.AddMolecule(_enzyme);
_hct = _individual.Organism.Parameter(CoreConstants.Parameters.HCT).Value;
_metabolizationProcess = _cloneManager.Clone(_compoundProcessRepository.ProcessByName(CoreConstantsForSpecs.Process.METABOLIZATION_SPECIFIC_FIRST_ORDER).DowncastTo <PartialProcess>());
_metabolizationProcess.Name = "My Partial Process";
_metabolizationProcess.Parameter(ConverterConstants.Parameter.CLspec).Value = 15;
_compound.AddProcess(_metabolizationProcess);
_simulationRunOptions = new SimulationRunOptions {
RaiseEvents = false
};
}
public MoleculesAndReactionsCreator(IObjectBaseFactory objectBaseFactory,
IMoleculeBuilderFactory moleculeBuilderFactory,
IParameterIdUpdater parameterIdUpdater,
IProcessToProcessBuilderMapper processBuilderMapper,
IParameterSetUpdater parameterSetUpdater,
IIndividualEnzymeFactory individualEnzymeFactory,
IIndividualTransporterFactory individualTransporterFactory,
IModelContainerMoleculeRepository modelContainerMoleculeRepo,
IStaticReactionRepository staticReactionRepository,
IMoleculeCalculationRetriever moleculeCalculationRetriever,
IInteractionKineticUpdater interactionKineticUpdater,
IInteractionTask interactionTask
)
{
_objectBaseFactory = objectBaseFactory;
_moleculeBuilderFactory = moleculeBuilderFactory;
_parameterIdUpdater = parameterIdUpdater;
_processBuilderMapper = processBuilderMapper;
_parameterSetUpdater = parameterSetUpdater;
_individualEnzymeFactory = individualEnzymeFactory;
_individualTransporterFactory = individualTransporterFactory;
_modelContainerMoleculeRepo = modelContainerMoleculeRepo;
_staticReactionRepository = staticReactionRepository;
_moleculeCalculationRetriever = moleculeCalculationRetriever;
_interactionKineticUpdater = interactionKineticUpdater;
_interactionTask = interactionTask;
_allMoleculeNames = new List <string>();
_moleculeWithTurnoverReactions = new List <IMoleculeBuilder>();
}
