public static IEnumerable <IHashableFeature> GetNFlankAny1AndNTermEAny2(NEC nec, string nflankAny, string nTermEAny)
        {
            NFlank nFlankFeature = NFlank.GetInstance();
            string nFlankRegion  = nFlankFeature.FeatureFunction(nec);

            if (-1 == nFlankRegion.IndexOfAny(nflankAny.ToCharArray()))
            {
                yield break;
            }

            NTermE nTermEFeature = NTermE.GetInstance();
            string nTermERegion  = nTermEFeature.FeatureFunction(nec);

            if (-1 == nTermERegion.IndexOfAny(nTermEAny.ToCharArray()))
            {
                yield break;
            }

            AnyIn anyFeature1 = AnyIn.GetInstance(nflankAny, nFlankFeature);
            AnyIn anyFeature2 = AnyIn.GetInstance(nTermEAny, nTermEFeature);
            And   andFeature  = And.GetInstance(anyFeature1, anyFeature2);

            Debug.Assert((bool)andFeature.Evaluate(nec)); // real assert - must only generate true features
            yield return(andFeature);
        }
        public static IEnumerable <IHashableFeature> GetAndNFlankNotNTermEEnumeration(NEC nec)
        {
            NFlank       nFlankFeature = NFlank.GetInstance();
            string       nFlankRegion  = nFlankFeature.FeatureFunction(nec);
            Set <string> aaSeqSet      = Set <string> .GetInstance(SpecialFunctions.SubstringEnumeration(nFlankRegion, 1));

            foreach (string aaSeq in aaSeqSet)
            {
                Not notFeature = Not.GetInstance(In.GetInstance(aaSeq, NTermE.GetInstance()));
                //Only generate the feature when the amino acid is not in NTermE
                if ((bool)notFeature.Evaluate(nec))
                {
                    In  inFeature  = In.GetInstance(aaSeq, nFlankFeature);
                    And andFeature = And.GetInstance(inFeature, notFeature);
                    Debug.Assert((bool)andFeature.Evaluate(nec)); // real assert - must only generate true features
                    yield return(andFeature);
                }
            }
        }