protected override void Context()
{
_pkCalculator = A.Fake <IPKValuesCalculator>();
_pkMapper = A.Fake <IPKValuesToPKAnalysisMapper>();
_dimensionRepository = A.Fake <IDimensionRepository>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkParameterRepository = A.Fake <IPKParameterRepository>();
sut = new PKAnalysisTask(_pkCalculator, _pkMapper, _dimensionRepository, _pkCalculationOptionsFactory, _pkParameterRepository);
}
protected override void Context()
{
_lazyLoadTask = A.Fake <ILazyLoadTask>();
_pkValuesCalculator = A.Fake <IPKValuesCalculator>();
_pkParameterRepository = A.Fake <IPKParameterRepository>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_entityPathResolver = A.Fake <IEntityPathResolver>();
sut = new PopulationPKAnalysesTask(_lazyLoadTask, _pkValuesCalculator, _pkParameterRepository, _pkCalculationOptionsFactory, _entityPathResolver);
_populationSimulation = A.Fake <PopulationSimulation>();
_outputSelections = new OutputSelections();
A.CallTo(() => _populationSimulation.OutputSelections).Returns(_outputSelections);
_allBodyWeights = new List <double>();
_bodyWeight = A.Fake <IParameter>();
var bodyWeightPath = "PATH";
A.CallTo(() => _populationSimulation.BodyWeight).Returns(_bodyWeight);
A.CallTo(() => _entityPathResolver.PathFor(_bodyWeight)).Returns(bodyWeightPath);
A.CallTo(() => _populationSimulation.AllValuesFor(bodyWeightPath)).Returns(_allBodyWeights);
A.CallTo(() => _populationSimulation.NumberOfItems).Returns(2);
_individualResult0 = new IndividualResults {
IndividualId = 0, Time = new QuantityValues {
Values = new[] { 1f, 2f }
}
};
_individualResult0.Add(new QuantityValues {
QuantityPath = _quantityPath1, Values = new[] { 10f, 20f }
});
_individualResult0.Add(new QuantityValues {
QuantityPath = _quantityPath2, Values = new[] { 11f, 21f }
});
_individualResult1 = new IndividualResults {
IndividualId = 1, Time = new QuantityValues {
Values = new[] { 3f, 4f }
}
};
_individualResult1.Add(new QuantityValues {
QuantityPath = _quantityPath1, Values = new[] { 30f, 40f }
});
_individualResult1.Add(new QuantityValues {
QuantityPath = _quantityPath2, Values = new[] { 31f, 41f }
});
_simulationResults = new SimulationResults {
_individualResult0, _individualResult1
};
_populationSimulation.Results = _simulationResults;
_pkParameter1 = new PKParameter {
Mode = PKParameterMode.Always, Name = "Cmax"
};
_pkParameter2 = new PKParameter {
Mode = PKParameterMode.Always, Name = "tMax"
};
A.CallTo(() => _pkParameterRepository.All()).Returns(new[] { _pkParameter1, _pkParameter2 });
}
protected override void Context()
{
_lazyLoadTask = A.Fake <ILazyLoadTask>();
_pkCalculator = A.Fake <IPKValuesCalculator>();
_pkMapper = A.Fake <IPKValuesToPKAnalysisMapper>();
_dimensionRepository = A.Fake <IDimensionRepository>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkParameterRepository = A.Fake <IPKParameterRepository>();
_entityPathResolver = A.Fake <IEntityPathResolver>();
sut = new PKAnalysesTask(_lazyLoadTask, _pkCalculator, _pkParameterRepository, _pkCalculationOptionsFactory, _entityPathResolver, _pkMapper, _dimensionRepository);
}
protected override void Context()
{
_vssCalculator = A.Fake <IVSSCalculator>();
_parameterFactory = A.Fake <IParameterFactory>();
_protocolMapper = A.Fake <IProtocolToSchemaItemsMapper>();
_protocolFactory = A.Fake <IProtocolFactory>();
_globalPKAnalysisRunner = A.Fake <IGlobalPKAnalysisRunner>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkAnalysisTask = A.Fake <IPKAnalysesTask>();
_interactionTask = A.Fake <IInteractionTask>();
_cloner = A.Fake <ICloner>();
sut = new GlobalPKAnalysisTask(_parameterFactory, _protocolMapper, _protocolFactory, _globalPKAnalysisRunner,
_pkAnalysisTask, _pkCalculationOptionsFactory, _vssCalculator, _interactionTask, _cloner);
var baseGrid = new BaseGrid("time", A.Fake <IDimension>());
_peripheralVenousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.PeripheralVenousBlood, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, _compoundName);
_venousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.VenousBlood, CoreConstants.Compartment.Plasma, CoreConstants.Observer.CONCENTRATION_IN_CONTAINER, _compoundName);
_individual = A.Fake <Individual>();
_species = new Species();
A.CallTo(() => _individual.Species).Returns(_species);
_compound = new Compound().WithName(_compoundName);
_compoundProperties = new CompoundProperties {
Compound = _compound
};
_simulationSchemaItems = new List <SchemaItem>();
_protocol = new SimpleProtocol();
_compoundProperties.ProtocolProperties.Protocol = _protocol;
A.CallTo(() => _protocolMapper.MapFrom(_protocol)).Returns(_simulationSchemaItems);
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_simulation.Properties.AddCompoundProperties(_compoundProperties);
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompId", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndividualId", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.DataRepository = new DataRepository {
_venousBloodPlasma, _peripheralVenousBloodPlasma
};
_venousBloodPK = new PKValues();
_venousBloodPK.AddValue(Constants.PKParameters.Vss, 10);
_venousBloodPK.AddValue(Constants.PKParameters.Vd, 11);
_venousBloodPK.AddValue(Constants.PKParameters.CL, 12);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 13);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 14);
_peripheralVenousBloodPK = new PKValues();
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vss, 21);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vd, 22);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.CL, 23);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 24);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 25);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max, 26);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max_tDLast_tDEnd, 27);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_venousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_venousBloodPK);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_peripheralVenousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_peripheralVenousBloodPK);
A.CallTo(() => _parameterFactory.CreateFor(A <string> ._, A <double> ._, A <string> ._, PKSimBuildingBlockType.Simulation))
.ReturnsLazily(s => new PKSimParameter().WithName((string)s.Arguments[0])
.WithDimension(A.Fake <IDimension>())
.WithFormula(new ConstantFormula((double)s.Arguments[1])));
}
protected override void Context()
{
_vssCalculator = A.Fake <IVSSCalculator>();
_parameterFactory = A.Fake <IParameterFactory>();
_protocolMapper = A.Fake <IProtocolToSchemaItemsMapper>();
_protocolFactory = A.Fake <IProtocolFactory>();
_globalPKAnalysisRunner = A.Fake <IGlobalPKAnalysisRunner>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkAnalysisTask = A.Fake <IPKAnalysesTask>();
_interactionTask = A.Fake <IInteractionTask>();
_cloner = A.Fake <ICloner>();
sut = new GlobalPKAnalysisTask(_parameterFactory, _protocolMapper, _protocolFactory, _globalPKAnalysisRunner,
_pkAnalysisTask, _pkCalculationOptionsFactory, _vssCalculator, _interactionTask, _cloner);
var baseGrid = new BaseGrid("time", A.Fake <IDimension>());
_peripheralVenousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, _compoundName);
_venousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.VENOUS_BLOOD, CoreConstants.Compartment.PLASMA, CoreConstants.Observer.CONCENTRATION_IN_CONTAINER, _compoundName);
_individual = A.Fake <Individual>();
_species = new Species();
A.CallTo(() => _individual.Species).Returns(_species);
_compound = new Compound().WithName(_compoundName);
_compoundProperties = new CompoundProperties {
Compound = _compound
};
_protocol = new SimpleProtocol();
_compoundProperties.ProtocolProperties.Protocol = _protocol;
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_simulation.Properties.AddCompoundProperties(_compoundProperties);
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompId", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndividualId", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.DataRepository = new DataRepository {
_venousBloodPlasma, _peripheralVenousBloodPlasma
};
_simulation.SimulationSettings = new SimulationSettings();
_simulation.OutputSchema = new OutputSchema();
_simulation.OutputSchema.AddInterval(new OutputInterval {
DomainHelperForSpecs.ConstantParameterWithValue(100).WithName(Constants.Parameters.END_TIME)
});
_simulation.Model = new OSPSuite.Core.Domain.Model {
Root = new Container()
};
_eventGroup = new EventGroup();
_application1 = new Container().WithName("App1").WithContainerType(ContainerType.Application);
_application1.Add(new MoleculeAmount().WithName(_compoundName));
_application1.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2 = new Container().WithName("App2").WithContainerType(ContainerType.Application);
_application2.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2.Add(new MoleculeAmount().WithName(_compoundName));
_simulation.Model.Root.Add(_eventGroup);
_eventGroup.Add(_application1);
_venousBloodPK = new PKValues();
_venousBloodPK.AddValue(Constants.PKParameters.Vss, 10);
_venousBloodPK.AddValue(Constants.PKParameters.Vd, 11);
_venousBloodPK.AddValue(Constants.PKParameters.CL, 12);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 13);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 14);
_peripheralVenousBloodPK = new PKValues();
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vss, 21);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vd, 22);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.CL, 23);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 24);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 25);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max, 26);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max_tDLast_tDEnd, 27);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_venousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_venousBloodPK);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_peripheralVenousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_peripheralVenousBloodPK);
A.CallTo(() => _parameterFactory.CreateFor(A <string> ._, A <double> ._, A <string> ._, PKSimBuildingBlockType.Simulation))
.ReturnsLazily(s => new PKSimParameter().WithName((string)s.Arguments[0])
.WithDimension(A.Fake <IDimension>())
.WithFormula(new ConstantFormula((double)s.Arguments[1])));
}
