public override void GlobalContext()
{
base.GlobalContext();
var simulationFile = HelperForSpecs.DataFile("S1.pkml");
var simulationPersister = Api.GetSimulationPersister();
var pkParametersTask = Api.GetPKParameterTask();
_simulation = simulationPersister.LoadSimulation(simulationFile);
_sensitivityAnalysis = new SensitivityAnalysis(_simulation)
{
NumberOfSteps = 2, VariationRange = 0.2
};
//Should calculate CMax/100
_userDefinedPKParameter = new UserDefinedPKParameter {
Name = "Toto", NormalizationFactor = 100, StandardPKParameter = StandardPKParameter.C_max
};
pkParametersTask.AddUserDefinedPKParameter(_userDefinedPKParameter);
_userDefinedCLParameter = new UserDefinedPKParameter {
Name = "MyCL", StandardPKParameter = StandardPKParameter.CL
};
pkParametersTask.AddUserDefinedPKParameter(_userDefinedCLParameter);
var containerTask = Api.GetContainerTask();
var liverVolumes = containerTask.AllParametersMatching(_simulation, "Organism|Liver|Volume");
_sensitivityAnalysis.AddParameterPaths(liverVolumes.Select(x => x.ConsolidatedPath()));
}
public string[] PotentialVariableParameterPathsFor(ISimulation simulation)
{
var sensitivityAnalysis = new SensitivityAnalysis(simulation);
var coreSensitivityAnalysis = _sensitivityAnalysisMapper.MapFrom(sensitivityAnalysis);
return(coreSensitivityAnalysis.AllSensitivityParameterPaths);
}
public override void GlobalContext()
{
base.GlobalContext();
var simulationFile = HelperForSpecs.DataFile("simple.pkml");
var simulationPersister = Api.GetSimulationPersister();
_simulation = simulationPersister.LoadSimulation(simulationFile);
_sensitivityAnalysis = new SensitivityAnalysis(_simulation)
{
NumberOfSteps = 1, VariationRange = 0.2
};
}
public override void GlobalContext()
{
base.GlobalContext();
var simulationFile = HelperForSpecs.DataFile("S1.pkml");
var simulationPersister = Api.GetSimulationPersister();
_simulation = simulationPersister.LoadSimulation(simulationFile);
_sensitivityAnalysis = new SensitivityAnalysis(_simulation)
{
NumberOfSteps = 2, VariationRange = 0.2
};
var containerTask = Api.GetContainerTask();
var liverVolumes = containerTask.AllParametersMatching(_simulation, "Organism|Liver|Volume");
_sensitivityAnalysis.AddParameterPaths(liverVolumes.Select(x => x.ConsolidatedPath()));
}
public async Task <SensitivityAnalysisRunResult> RunAsync(
SensitivityAnalysis sensitivityAnalysis,
SensitivityAnalysisRunOptions runOptions = null)
{
var options = runOptions ?? new SensitivityAnalysisRunOptions();
using (var sensitivityAnalysisEngine = _sensitivityAnalysisEngineFactory.Create())
try
{
initializeProgress(sensitivityAnalysisEngine, options);
var coreSensitivityAnalysis = _sensitivityAnalysisMapper.MapFrom(sensitivityAnalysis);
await sensitivityAnalysisEngine.StartAsync(coreSensitivityAnalysis, options);
return(coreSensitivityAnalysis.Results);
}
finally
{
simulationTerminated(sensitivityAnalysisEngine);
}
}
public override void GlobalContext()
{
base.GlobalContext();
var simulationFile = HelperForSpecs.DataFile("S1.pkml");
var simulationPersister = Api.GetSimulationPersister();
_simulation = simulationPersister.LoadSimulation(simulationFile);
_sensitivityAnalysis = new SensitivityAnalysis(_simulation)
{
NumberOfSteps = 2, VariationRange = 0.2
};
var containerTask = Api.GetContainerTask();
var liverVolumes = containerTask.AllParametersMatching(_simulation, "Organism|Liver|Volume");
_sensitivityAnalysis.AddParameters(liverVolumes);
_sensitivityAnalysisRunner = Api.GetSensitivityAnalysisRunner();
_sensitivityAnalysisRunResult = _sensitivityAnalysisRunner.Run(_sensitivityAnalysis);
_allPKParameterSensitivities = _sensitivityAnalysisRunResult.AllPKParameterSensitivities;
}
public SensitivityAnalysisRunResult Run(SensitivityAnalysis sensitivityAnalysis, SensitivityAnalysisRunOptions runOptions = null) => RunAsync(sensitivityAnalysis, runOptions).Result;
