public void ParseVcfLine_NonInformativeAlleles_Alone_NotFiltered() { const string vcfLine1 = "chr1 13133 . T <*> 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; const string vcfLine2 = "chr1 13133 . T * 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; const string vcfLine3 = "chr1 13133 . T <M> 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(13133, "T", 'A', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider); var position1 = AnnotationUtilities.ParseVcfLine(vcfLine1, refMinorProvider.Object, variantFactory, seqProvider.RefNameToChromosome); var position2 = AnnotationUtilities.ParseVcfLine(vcfLine2, refMinorProvider.Object, variantFactory, seqProvider.RefNameToChromosome); var position3 = AnnotationUtilities.ParseVcfLine(vcfLine3, refMinorProvider.Object, variantFactory, seqProvider.RefNameToChromosome); var annotatedVariants1 = Annotator.GetAnnotatedVariants(position1.Variants); var annotatedVariants2 = Annotator.GetAnnotatedVariants(position2.Variants); var annotatedVariants3 = Annotator.GetAnnotatedVariants(position3.Variants); // SimplePositions unchanged Assert.Equal("<*>", position1.AltAlleles[0]); Assert.Equal("*", position2.AltAlleles[0]); Assert.Equal("<M>", position3.AltAlleles[0]); // Variants not filtered Assert.Equal("<*>", annotatedVariants1[0].Variant.AltAllele); Assert.Equal("*", annotatedVariants2[0].Variant.AltAllele); Assert.Equal("<M>", annotatedVariants3[0].Variant.AltAllele); }
public void ParseVcfLine_NonInformativeAlleles_WithNormalAllele_NotFiltered() { const string vcfLine1 = "chr1 13133 . T <*>,G 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; const string vcfLine2 = "chr1 13133 . T *,C 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; const string vcfLine3 = "chr1 13133 . T <M>,A 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; const string vcfLine4 = "chr1 13133 . T A,<NON_REF> 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(13133, "T", 'A', ChromosomeUtilities.RefNameToChromosome); var refNameToChromosome = seqProvider.RefNameToChromosome; var variantFactory = new VariantFactory(seqProvider); var position1 = AnnotationUtilities.ParseVcfLine(vcfLine1, refMinorProvider.Object, variantFactory, refNameToChromosome); var position2 = AnnotationUtilities.ParseVcfLine(vcfLine2, refMinorProvider.Object, variantFactory, refNameToChromosome); var position3 = AnnotationUtilities.ParseVcfLine(vcfLine3, refMinorProvider.Object, variantFactory, refNameToChromosome); var position4 = AnnotationUtilities.ParseVcfLine(vcfLine4, refMinorProvider.Object, variantFactory, refNameToChromosome); var annotatedVariants1 = Annotator.GetAnnotatedVariants(position1.Variants); var annotatedVariants2 = Annotator.GetAnnotatedVariants(position2.Variants); var annotatedVariants3 = Annotator.GetAnnotatedVariants(position3.Variants); var annotatedVariants4 = Annotator.GetAnnotatedVariants(position4.Variants); // SimplePositions Assert.Equal(new[] { "<*>", "G" }, position1.AltAlleles); Assert.Equal(new[] { "*", "C" }, position2.AltAlleles); Assert.Equal(new[] { "<M>", "A" }, position3.AltAlleles); Assert.Equal(new[] { "A", "<NON_REF>" }, position4.AltAlleles); // Variants Assert.Equal(new[] { "<*>", "G" }, annotatedVariants1.Select(x => x.Variant.AltAllele).ToArray()); Assert.Equal(new[] { "*", "C" }, annotatedVariants2.Select(x => x.Variant.AltAllele).ToArray()); Assert.Equal(new[] { "<M>", "A" }, annotatedVariants3.Select(x => x.Variant.AltAllele).ToArray()); Assert.Equal(new[] { "A", "<NON_REF>" }, annotatedVariants4.Select(x => x.Variant.AltAllele).ToArray()); }
public void GetNextPosition() { const string vcfLine = "chr1 13133 . T C 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; var lines = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920", "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NHL-16", vcfLine }; AddLines(lines); var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(13133, "T", 'A', ChromosomeUtilities.RefNameToChromosome); IPosition observedResult; using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, refMinorProvider.Object, new NullRecomposer(), new NullVcfFilter(), _vidCreator, null)) { observedResult = vcfReader.GetNextPosition(); } var expectedResult = new Position(ChromosomeUtilities.Chr1, 13133, 13133, "T", new[] { "C" }, 36, new[] { "PASS" }, null, null, null, vcfLine.Split('\t'), new[] { false }, false); Assert.NotNull(observedResult); Assert.Equal(expectedResult.End, observedResult.End); Assert.Equal(expectedResult.AltAlleles, observedResult.AltAlleles); Assert.Equal(expectedResult.Filters, observedResult.Filters); Assert.Equal(expectedResult.Quality, observedResult.Quality); Assert.Equal(expectedResult.VcfFields, observedResult.VcfFields); }
public void ParseVcfLine_line_with_only_NonRef_is_refMinor() { const string vcfLine = "1 10628385 . C <NON_REF> . LowGQX;HighDPFRatio END=10628385;BLOCKAVG_min30p3a GT:GQX:DP:DPF 0/0:24:9:18"; var chromosome = new Chromosome("chr1", "1", 0); var refMinorProvider = new Mock <IRefMinorProvider>(); refMinorProvider.Setup(x => x.GetGlobalMajorAllele(chromosome, 10628385)).Returns("T"); var seqProvider = ParserTestUtils.GetSequenceProvider(10628385, "C", 'A', new Dictionary <string, IChromosome> { ["1"] = chromosome }); var refNameToChromosome = seqProvider.RefNameToChromosome; var variantFactory = new VariantFactory(seqProvider); var position = AnnotationUtilities.ParseVcfLine(vcfLine, refMinorProvider.Object, variantFactory, refNameToChromosome); var annotatedVariants = Annotator.GetAnnotatedVariants(position.Variants); Assert.Equal("C", position.RefAllele); Assert.Equal(new[] { "<NON_REF>" }, position.AltAlleles); Assert.Equal("T", position.Variants[0].RefAllele); Assert.Equal("C", position.Variants[0].AltAllele); // Variants Assert.Equal(new[] { "C" }, annotatedVariants.Select(x => x.Variant.AltAllele).ToArray()); }
public void GetAllPositions() { var seqProvider = ParserTestUtils.GetSequenceProvider(10329, "AC", 'A', _chromDict); var positions = PreLoadUtilities.GetPositions(GetVcfStream(), null, seqProvider); Assert.Equal(2, positions.Count); Assert.Equal(4, positions[Chrom1].Count); Assert.Equal(4, positions[Chrom2].Count); }
public void GetPositions_inRange() { var chromosome = new Chromosome("chr1", "1", 0); var annotationRange = new GenomicRange(new GenomicPosition(chromosome, 10019), new GenomicPosition(chromosome, 10290)); var seqProvider = ParserTestUtils.GetSequenceProvider(10329, "AC", 'A', _chromDict); var positions = PreLoadUtilities.GetPositions(GetVcfStream(), annotationRange, seqProvider); Assert.Single(positions); Assert.Equal(3, positions[Chrom1].Count); }
public void GetPositions_inRange() { var annotationRange = new GenomicRange(new GenomicPosition(ChromosomeUtilities.Chr1, 10019), new GenomicPosition(ChromosomeUtilities.Chr1, 10290)); var seqProvider = ParserTestUtils.GetSequenceProvider(10329, "AC", 'A', ChromosomeUtilities.RefNameToChromosome); (var positions, _) = PreLoadUtilities.GetPositions(GetVcfStream(), annotationRange, seqProvider, null); Assert.Single(positions); Assert.Equal(3, positions[ChromosomeUtilities.Chr1].Count); }
public void ValidateVcfHeader_ExceptionThrown_NoChromHeaderLine() { var headers = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920" }; AddLines(headers); var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); var reader = FileUtilities.GetStreamReader(_ms); Assert.Throws <UserErrorException>(() => VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())); }
public void CheckContigId_IncorrectAutoAndSexChromLength_ThrowException(string contigLine) { var headers = new[] { "##fileformat=VCFv4.1", contigLine, "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT"}; AddLines(headers); var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) Assert.Throws <UserErrorException>(() => VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())); }
public void ValidateVcfHeader_ExceptionThrown_NoFileFormat() { var headers = new[] { "##Some comments", "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NHL-16 NHL-17"}; AddLines(headers); var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); var reader = FileUtilities.GetStreamReader(_ms); Assert.Throws <UserErrorException>(() => VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())); }
public void GetAllPositions() { //we only need the sequence provider for variant rotation. var seqProvider = ParserTestUtils.GetSequenceProvider(10329, "AC", 'A', ChromosomeUtilities.RefNameToChromosome); (var positions, _) = PreLoadUtilities.GetPositions(GetVcfStream(), null, seqProvider, null); Assert.Equal(2, positions.Count); Assert.Equal(4, positions[ChromosomeUtilities.Chr1].Count); Assert.Equal(4, positions[ChromosomeUtilities.Chr2].Count); }
public void RemoveConflictingAlleles_does_not_remove_duplicates() { var seqProvider = ParserTestUtils.GetSequenceProvider(70220313, "TGCC", 'A', _chromDict); var topMedReader = new TopMedReader(new StreamReader(GetDupItemsStream()), seqProvider); var items = topMedReader.GetItems().ToList(); var saItems = new List <ISupplementaryDataItem>(items); saItems = SuppDataUtilities.RemoveConflictingAlleles(saItems, false); Assert.Single(saItems); }
public void CheckContigId_InferredAssemblyIsUnknown_GivenIrregularChrom(string contigLine) { var headers = new[] { "##fileformat=VCFv4.1", contigLine, "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT"}; AddLines(headers); var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())) { Assert.Equal(GenomeAssembly.Unknown, vcfReader.InferredGenomeAssembly); } }
public void ToString_translocation_breakend(string refAllele, string altAllele, int position, string expectedVid) { var chromosome1 = new Chromosome("chr1", "1", 0); var seqProvider = ParserTestUtils.GetSequenceProvider(position, refAllele, 'A', new Dictionary <string, IChromosome> { { "1", chromosome1 } }); var variantFactory = new VariantFactory(seqProvider); var breakEnds = variantFactory.GetTranslocationBreakends(chromosome1, refAllele, altAllele, position); Assert.NotNull(breakEnds); Assert.Single(breakEnds); Assert.Equal(expectedVid, breakEnds[0].ToString()); }
public void ToString_deletion() { var chromosome1 = new Chromosome("chr1", "1", 0); var seqProvider = ParserTestUtils.GetSequenceProvider(1594584, "T", 'A', new Dictionary <string, IChromosome> { { "1", chromosome1 } }); var variantFactory = new VariantFactory(seqProvider); var breakEnds = variantFactory.GetSvBreakEnds("1", 1594584, VariantType.deletion, 1660503); Assert.NotNull(breakEnds); Assert.Equal(2, breakEnds.Length); Assert.Equal("1:1594584:+:1:1660504:+", breakEnds[0].ToString()); Assert.Equal("1:1660504:-:1:1594584:-", breakEnds[1].ToString()); }
public void ToString_duplication() { var chromosome1 = new Chromosome("chr1", "1", 0); var seqProvider = ParserTestUtils.GetSequenceProvider(37820921, "T", 'A', new Dictionary <string, IChromosome> { { "1", chromosome1 } }); var variantFactory = new VariantFactory(seqProvider); var breakEnds = variantFactory.GetSvBreakEnds("1", 37820921, VariantType.duplication, 38404543); Assert.NotNull(breakEnds); Assert.Equal(2, breakEnds.Length); Assert.Equal("1:38404543:+:1:37820921:+", breakEnds[0].ToString()); Assert.Equal("1:37820921:-:1:38404543:-", breakEnds[1].ToString()); }
public void Duplicated_headlines_are_removed() { var headers = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920", "##dataSource=ClinVar,version:unknown,release date:2016-09-01", "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NHL-16 NHL-17"}; AddLines(headers); IEnumerable <string> observedHeaders; var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())) { observedHeaders = vcfReader.GetHeaderLines(); } Assert.Equal(4, observedHeaders.Count()); }
public void HeaderLines_are_parsed() { var headers = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920", "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NHL-16"}; AddLines(headers); IEnumerable <string> observedHeaders; var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())) { observedHeaders = vcfReader.GetHeaderLines(); } Assert.Equal(headers, observedHeaders.ToArray()); }
public void Sample_names_are_reported() { var headers = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920", "#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NHL-16 NHL-17"}; AddLines(headers); string[] samples; var seqProvider = ParserTestUtils.GetSequenceProvider(1000, "A", 'T', _refNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, null, null, new NullVcfFilter())) { samples = vcfReader.GetSampleNames(); } Assert.Equal(new[] { "NHL-16", "NHL-17" }, samples); }
public void GetAllPositions_skip_refs() { //we only need the sequence provider for variant rotation. var seqProvider = ParserTestUtils.GetSequenceProvider(10329, "AC", 'A', ChromosomeUtilities.RefNameToChromosome); var refMinorProvider = ParserTestUtils.GetRefMinorProvider( new List <(IChromosome chrom, int position, string globalMinor)> { (ChromosomeUtilities.Chr1, 10275, "A") } ); (var positions, _) = PreLoadUtilities.GetPositions(GetRefMinorVcfStream(), null, seqProvider, refMinorProvider); Assert.Equal(2, positions.Count); Assert.Equal(5, positions[ChromosomeUtilities.Chr1].Count); Assert.Equal(4, positions[ChromosomeUtilities.Chr2].Count); }
public void ParseVcfLine_line_with_only_NonRef_is_not_refMinor() { const string vcfLine = "1 10005 . C <NON_REF> . LowGQX END=10034;BLOCKAVG_min30p3a GT:GQX:DP:DPF 0/0:3:1:0"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(10005, "C", 'A', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider.Sequence, _vidCreator); var position = AnnotationUtilities.ParseVcfLine(vcfLine, refMinorProvider.Object, seqProvider, null, variantFactory); var annotatedVariants = Annotator.GetAnnotatedVariants(position.Variants); Assert.Equal("C", position.RefAllele); Assert.Equal(new[] { "<NON_REF>" }, position.AltAlleles); Assert.Null(position.Variants); Assert.Null(annotatedVariants); }
public void Test_crash_caused_by_variant_trimming() { const string vcfLine1 = "chr1 8021910 rs373653682 GGTGCTGGACGGTGTCCCT G . . ."; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(8021910, "GGTGCTGGACGGTGTCCCT", 'A', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider.Sequence, _vidCreator); var position1 = AnnotationUtilities.ParseVcfLine(vcfLine1, refMinorProvider.Object, seqProvider, null, variantFactory); var annotatedVariants1 = Annotator.GetAnnotatedVariants(position1.Variants); // SimplePositions Assert.Equal(new[] { "G" }, position1.AltAlleles); // Variants Assert.Equal(new[] { "" }, annotatedVariants1.Select(x => x.Variant.AltAllele).ToArray()); }
public void GetJsonString_fisherStrand() { const string vcfLine = "21\t9411410\t.\tC\tT\t9.51\tDRAGENSnpHardQUAL\tAC=2;AF=1.000;AN=2;DP=2;FS=0.000;MQ=100.00;QD=9.51;SOR=1.609"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(9411410, "C", 'A', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider.Sequence, new VariantId()); var position = AnnotationUtilities.ParseVcfLine(vcfLine, refMinorProvider.Object, seqProvider, null, variantFactory); IVariant[] variants = GetVariants(); IAnnotatedVariant[] annotatedVariants = Annotator.GetAnnotatedVariants(variants); var annotatedPosition = new AnnotatedPosition(position, annotatedVariants); string observedResult = annotatedPosition.GetJsonString(); Assert.NotNull(observedResult); Assert.Contains("\"fisherStrandBias\":0", observedResult); }
public void GetJsonString_BreakEndEventId() { const string vcfLine = "1\t38432782\tMantaBND:2312:0:1:0:0:0:0\tG\tG]6:28863899]\t971\tPASS\tSVTYPE=BND;MATEID=MantaBND:2312:0:1:0:0:0:1;EVENT=MantaBND:2312:0:1:0:0:0:0;JUNCTION_QUAL=716;BND_DEPTH=52;MATE_BND_DEPTH=56"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(38432782, "G", 'C', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider.Sequence, new VariantId()); var position = AnnotationUtilities.ParseVcfLine(vcfLine, refMinorProvider.Object, seqProvider, null, variantFactory); IVariant[] variants = GetVariants(); IAnnotatedVariant[] annotatedVariants = Annotator.GetAnnotatedVariants(variants); var annotatedPosition = new AnnotatedPosition(position, annotatedVariants); string observedResult = annotatedPosition.GetJsonString(); Assert.NotNull(observedResult); Assert.Contains("\"breakendEventId\":\"MantaBND:2312:0:1:0:0:0:0\"", observedResult); }
public void GetJsonString_StrelkaSomatic() { const string vcfLine = "chr1 13813 . T G . LowQscore SOMATIC;QSS=33;TQSS=1;NT=ref;QSS_NT=16;TQSS_NT=1;SGT=TT->GT;DP=266;MQ=23.89;MQ0=59;ALTPOS=69;ALTMAP=37;ReadPosRankSum=1.22;SNVSB=5.92;PNOISE=0.00;PNOISE2=0.00;VQSR=1.93"; var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(13813, "T", 'C', ChromosomeUtilities.RefNameToChromosome); var variantFactory = new VariantFactory(seqProvider.Sequence, new VariantId()); var position = AnnotationUtilities.ParseVcfLine(vcfLine, refMinorProvider.Object, seqProvider, variantFactory); IVariant[] variants = GetVariants(); IAnnotatedVariant[] annotatedVariants = Annotator.GetAnnotatedVariants(variants); var annotatedPosition = new AnnotatedPosition(position, annotatedVariants); string observedResult = annotatedPosition.GetJsonString(); Assert.NotNull(observedResult); Assert.Contains("\"jointSomaticNormalQuality\":16", observedResult); Assert.Contains("\"recalibratedQuality\":1.93", observedResult); }
public void CheckSampleConsistency_noSample() { const string vcfLine1 = "chr1 13133 . T C 36.00 PASS SNVSB=0.0;SNVHPOL=4"; const string vcfLine2 = "chr1 13133 . T A 36.00 PASS SNVSB=0.0;SNVHPOL=4 GT:GQ:GQX:DP:DPF:AD 0/1:62:20:7:1:3,4"; var lines = new[] { "##fileformat=VCFv4.1", "##FILTER=<ID=PASS,Description=\"All filters passed\">", "##fileDate=20160920", "#CHROM POS ID REF ALT QUAL FILTER INFO", vcfLine1, vcfLine2 }; AddLines(lines); var refMinorProvider = new Mock <IRefMinorProvider>(); var seqProvider = ParserTestUtils.GetSequenceProvider(13133, "T", 'A', ChromosomeUtilities.RefNameToChromosome); using (var reader = FileUtilities.GetStreamReader(_ms)) using (var vcfReader = VcfReader.Create(reader, reader, seqProvider, refMinorProvider.Object, new NullRecomposer(), new NullVcfFilter(), _vidCreator, null)) { //first line is valid. So, no exception Assert.NotNull(vcfReader.GetNextPosition()); // second line has invalid number of sample fields, so it will throw exception Assert.Throws <UserErrorException>(() => vcfReader.GetNextPosition()); } }