internal static IWittyerVariant Create([NotNull] IVcfVariant baseVariant, string sample, double percentageDistance, uint basepairDistance, IReadOnlyList <uint> bins, WittyerVariantType svType) { if (svType == WittyerVariantType.Invalid) { throw new InvalidDataException( $"Invalid {VcfConstants.SvTypeKey} in variant: \n{baseVariant}\nNot sure why you got here though. Check with a witty.er developer!"); } var end = baseVariant.Position + baseVariant.GetSvLength(); var baseInterval = BedInterval.Create(baseVariant.Position, end); var borderInterval = baseVariant.Position.CalculateBorderInterval(baseInterval, baseVariant.ParseCi(WittyerConstants.Cipos), percentageDistance, basepairDistance); // wittyerVariant should all have end border, it's a matter of how to find it, // either END key in INFO field, sort out through SVLEN or other ways, details can be defined in FindEndBorder() later var endInterval = (end - 1).CalculateBorderInterval(baseInterval, baseVariant.ParseCi(WittyerConstants.Ciend), percentageDistance, basepairDistance); var posContigAndInterval = ContigAndInterval.Create(baseVariant.Contig, borderInterval.Start, borderInterval.Stop + 1); var endContigAndInterval = ContigAndInterval.Create(baseVariant.Contig, endInterval.Start, endInterval.Stop + 1); return(Create(baseVariant, baseInterval, svType, posContigAndInterval, Winner.Create(svType, baseInterval, bins), new List <OverlapAnnotation>(), WittyerSample.CreateOverall(baseVariant, sample, svType == WittyerVariantType.CopyNumberReference), endContigAndInterval)); }
internal static IInterval <uint> ToBedInterval([NotNull] this IVcfVariant baseVariant, bool throwException, out uint endVal, out bool sharedFirstBase) { endVal = baseVariant.Position; if (IsSimpleSequence(baseVariant, out var refLenVal, out sharedFirstBase, out var sharedLastBase, false)) // first need to save the original end before normalizing { endVal += refLenVal; if (baseVariant.Alts.Count > 0) // refsites don't have Alts in VariantUtils { baseVariant = baseVariant.TryNormalizeVariant(VariantNormalizer.TrimCommonBases, 0).GetOrThrow(); } } var refLen = baseVariant.GetSvLength(throwException, out sharedFirstBase, out sharedLastBase, out var endPos); if (refLen == null) // means insertion of unknown length. { return(null); } if (endPos != null) { endVal = endPos.Value; } var start = sharedFirstBase || baseVariant.Position == 0 ? baseVariant.Position : baseVariant.Position - 1; var end = start + refLen.Value; if (sharedLastBase) // rare case { end--; } return(BedInterval.Create(start, end)); }