private void addLiverZoneCompartmentObserver(IObserverBuilder observerBuilder, string compartment, IObserverBuildingBlock observerBuildingBlock, Compound compound)
{
var observerName = CoreConstants.CompositeNameFor(observerBuilder.Name, CoreConstants.Organ.Liver, compartment);
if (observerBuildingBlock.ExistsByName(observerName))
{
return;
}
var observer = _objectBaseFactory.Create <IContainerObserverBuilder>()
.WithName(observerName)
.WithDimension(_dimensionRepository.Fraction);
observer.ForAll = false;
observerBuilder.MoleculeNames().Each(observer.AddMoleculeName);
observer.ContainerCriteria = Create.Criteria(x => x.With(CoreConstants.Organ.Liver)
.And.With(compartment)
.And.Not(CoreConstants.Compartment.Pericentral)
.And.Not(CoreConstants.Compartment.Periportal));
var formula = _objectBaseFactory.Create <ExplicitFormula>()
.WithName(observerName)
.WithFormulaString("(M_periportal + M_pericentral)/" + TOTAL_DRUG_MASS_ALIAS)
.WithDimension(_dimensionRepository.Fraction);
formula.AddObjectPath(createZoneAmoutPath(compartment, CoreConstants.Compartment.Periportal, "M_periportal"));
formula.AddObjectPath(createZoneAmoutPath(compartment, CoreConstants.Compartment.Pericentral, "M_pericentral"));
formula.AddObjectPath(createTotalDrugMassObjectPath(compound.Name));
observer.Formula = formula;
observerBuildingBlock.Add(observer);
observerBuildingBlock.AddFormula(formula);
}
public void should_create_WholeOrganInclFcRn_Observer()
{
_observers.ExistsByName(_observerName).ShouldBeTrue();
}
