/// <summary>
/// Author: Andy Tang
/// </summary>
protected void Page_LoadComplete(object sender, EventArgs e)
{
try
{
ScriptManager.RegisterStartupScript(Page, GetType(), "D_3DViewer_Info", "javascript:loadDrugLigandInfo('" + drug.Drug_PDB_ID + "');", true);
}
catch (Exception)
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
ExceptionUtilities.DisplayAlert(this, QUERY_PAGE);
}
}
/// <summary>
/// Author: Ryan Liang
/// </summary>
protected void Download_Summary_Click(object sender, EventArgs e)
{
try
{
Response.ClearContent();
Response.Clear();
Response.ContentType = "application/x-unknown";
Response.AddHeader("Content-Disposition", "attachment; " +
"filename=DrugProNET_PDB ID " + Session["PDB_File_ID"] + "_Bond Distance " +
Session["interaction_distance"] + " Å_Side Chain Interactions.xlsx");
List <string> header = new List <string>()
{
"Protein Amino Acid Residue",
"Number of Interactions with Drug Atoms",
"Average Distance of All Interactions(Å)",
"# Interactions : Distance Ratio",
};
List <InteractionSummaryRow> interactionSummaryRows = (List <InteractionSummaryRow>)Session["interactionSummaryRows"];
List <List <string> > data = new List <List <string> >();
foreach (InteractionSummaryRow interactionSummaryRow in interactionSummaryRows)
{
List <string> dataRow = new List <string>
{
interactionSummaryRow.proteinAAResidue,
interactionSummaryRow.numberOfInteractionsWithDrugAtom.ToString(),
interactionSummaryRow.averageDistanceOfAllInteractions.ToString(),
interactionSummaryRow.interactionToDistanceRatio.ToString(),
};
data.Add(dataRow);
}
Response.BinaryWrite(ExcelWriter.CreateAsStream(header, data).ToArray());
Response.Flush();
Response.SuppressContent = true;
System.Web.HttpContext.Current.ApplicationInstance.CompleteRequest();
}
catch (Exception)
{
ExceptionUtilities.DisplayAlert(this, DEFAULT_REDIRECT_PAGE);
}
}
/// <summary>
/// Author: Andy Tang
/// </summary>
protected new void Page_Load(object sender, EventArgs e)
{
base.Page_Load(sender, e);
string query = Request.QueryString["query_string"];
Protein_Information protein = EF_Data.GetProteinsInfoQuery(query).FirstOrDefault();
if (protein != null)
{
LoadData(protein);
}
else
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
ExceptionUtilities.DisplayAlert(this, QUERY_PAGE);
}
}
/// <summary>
/// Author: Garth Nelson
/// </summary>
protected new void Page_Load(object sender, EventArgs e)
{
base.Page_Load(sender, e);
SNV_ID_Key = Request.QueryString["query_string"];
try
{
string stringAfterPDot = SNV_ID_Key.Substring(SNV_ID_Key.IndexOf("p.") + 2);
string specifiedAAType = new string(stringAfterPDot.TakeWhile(c => char.IsLetter(c)).ToArray());
string specifiedAANumber = new string(stringAfterPDot.Substring(specifiedAAType.Length).TakeWhile(c => char.IsNumber(c)).ToArray());
string specifiedAA = specifiedAAType + "-" + specifiedAANumber;
mutations = EF_Data.GetMutationsBySNVIDKey(SNV_ID_Key);
proteinMutation = EF_Data.GetMutationBySNVIDKey(SNV_ID_Key);
protein = EF_Data.GetProteinByUniprotID(proteinMutation.UniProt_ID);
foreach (SNV_Mutation mutation in mutations)
{
Drug_Information drug = EF_Data.GetDrugByDrugPDBID(mutation.Drug_PDB_ID);
drugs.Add(drug);
PDB_Interaction interaction = EF_Data.GetPDB_Interaction(mutation.UniProt_ID, mutation.Drug_PDB_ID, specifiedAA);
interactions.Add(interaction);
}
Session["drugs"] = drugs;
Session["interactions"] = interactions;
Session["mutations"] = mutations;
Session["SNV_ID_Key"] = SNV_ID_Key;
LoadSNVID(SNV_ID_Key);
LoadTargetGeneID(protein, mutations[0]);
CreateIDofPDILinkedSNVTable(drugs, interactions, mutations);
}
catch (Exception)
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
ExceptionUtilities.DisplayAlert(this, QUERY_PAGE);
}
}
/// <summary>
/// Author: Garth Nelson
/// </summary>
protected new void Page_Load(object sender, EventArgs e)
{
base.Page_Load(sender, e);
try
{
string protein_specification = Request.QueryString["query_string"];
string drug_specification = Request.QueryString["drug_specification"];
string SNV_Key = Request.QueryString["snv_id_key"];
Session["SNV_Key"] = SNV_Key;
Protein_Information protein = EF_Data.GetProtein(protein_specification);
Drug_Information drug = EF_Data.GetDrugUsingDropDownName(drug_specification);
PDB_Information PDB = EF_Data.GetPDBInfo(protein, drug);
string[] SNV_KEYsplit = SNV_Key.Split('-');
// Retrieve second and third elements
string amino_acid_specification = SNV_KEYsplit[1] + "-" + SNV_KEYsplit[2];
PDB_Interaction interaction = EF_Data.GetPDB_Interaction(protein.Uniprot_ID, drug.Drug_PDB_ID, amino_acid_specification);
mutation = EF_Data.GetMutationBySNVKey(SNV_Key);
Session["mutation"] = mutation;
LoadProtein(protein, interaction, mutation);
LoadDrug(drug, mutation);
LoadPDB_Info(PDB);
CreateSNVIdentificationTable(mutation);
}
catch (Exception)
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
ExceptionUtilities.DisplayAlert(this, QUERY_PAGE);
}
}
/// <summary>
/// Author: Ryan Liang
/// </summary>
protected void Download_List_Click(object sender, EventArgs e)
{
try
{
Dictionary <PDB_Distance, string> DistanceAndUniprotResidueNumbers = (Dictionary <PDB_Distance, string>)Session["DistanceAndUniprotResidueNumbers"];
interaction_distance = (double)Session["interaction_distance"];
protein_chain = (bool)Session["protein_chain"];
protein_atoms = (bool)Session["protein_atoms"];
protein_residues = (bool)Session["protein_residues"];
protein_residue_numbers = (bool)Session["protein_residue_numbers"];
drug_atoms = (bool)Session["drug_atoms"];
Response.ClearContent();
Response.Clear();
Response.ContentType = "application/x-unknown";
Response.AddHeader("Content-Disposition", "attachment; " +
"filename=DrugProNET_PDB ID " + Session["PDB_File_ID"] + "_Bond Distance " +
Session["interaction_distance"] + " Å_Atom Interactions.xlsx");
List <string> header = new List <string>()
{
"Distance (Å)",
};
if (protein_chain)
{
header.Add("Protein Chain");
}
if (protein_residue_numbers)
{
header.Add("Protein Residue #");
}
if (protein_residues)
{
header.Add("Amino Acid Residue Type");
}
if (protein_atoms)
{
header.Add("Amino Acid Residue Atom");
}
if (drug_atoms)
{
header.Add("Drug Atom");
}
List <List <string> > data = new List <List <string> >();
foreach (KeyValuePair <PDB_Distance, string> kvp in DistanceAndUniprotResidueNumbers)
{
List <string> dataRow = new List <string>
{
kvp.Key.Distance.ToString()
};
if (protein_chain)
{
dataRow.Add(kvp.Key.Protein_Chain);
}
if (protein_residue_numbers)
{
dataRow.Add(kvp.Value);
}
if (protein_residues)
{
dataRow.Add(kvp.Key.Protein_Residue);
}
if (protein_atoms)
{
dataRow.Add(kvp.Key.Protein_Atom);
}
if (drug_atoms)
{
dataRow.Add(kvp.Key.Compound_Atom);
}
data.Add(dataRow);
}
Response.BinaryWrite(ExcelWriter.CreateAsStream(header, data).ToArray());
Response.Flush();
Response.SuppressContent = true;
System.Web.HttpContext.Current.ApplicationInstance.CompleteRequest();
}
catch (Exception)
{
ExceptionUtilities.DisplayAlert(this, DEFAULT_REDIRECT_PAGE);
}
}
/// <summary>
/// Author: Andy Tang, Ryan Liang
/// </summary>
protected new void Page_Load(object sender, EventArgs e)
{
base.Page_Load(sender, e);
if (!IsPostBack)
{
string fromPage = null;
string query_string = null;
try
{
query_string = Request.QueryString["query_string"];
drug_specification = Request.QueryString["drug_specification"];
protein_specification = Request.QueryString["protein_specification"];
if (!string.IsNullOrEmpty(drug_specification))
{
protein_specification = query_string;
fromPage = "protein";
}
else if (!string.IsNullOrEmpty(protein_specification))
{
drug_specification = query_string;
fromPage = "drug";
}
drug = EF_Data.GetDrugsQuery(drug_specification).FirstOrDefault();
protein = EF_Data.GetProteinsInfoQuery(protein_specification).FirstOrDefault();
PDB = EF_Data.GetPDBInfo(protein, drug);
Session["PDB_File_ID"] = PDB.PDB_File_ID;
interaction_distance = double.Parse(Request.QueryString["interaction_distance"]);
protein_chain = bool.Parse(Request.QueryString["protein_chain"]);
protein_atoms = bool.Parse(Request.QueryString["protein_atoms"]);
protein_residues = bool.Parse(Request.QueryString["protein_residues"]);
protein_residue_numbers = bool.Parse(Request.QueryString["protein_residue_numbers"]);
drug_atoms = bool.Parse(Request.QueryString["drug_atoms"]);
Session["interaction_distance"] = interaction_distance;
}
catch (Exception)
{
throw;
}
if (drug == null || protein == null || PDB == null)
{
Page.Master.FindControl("BodyContentPlaceHolder").Visible = false;
if (fromPage != null)
{
ExceptionUtilities.DisplayAlert(this, fromPage.Equals("drug") ? DRUG_QUERY_PAGE : PROTEIN_QUERY_PAGE);
}
else
{
ExceptionUtilities.DisplayAlert(this, DEFAULT_REDIRECT_PAGE);
}
}
else
{
Session["interaction_distance"] = interaction_distance;
Session["protein_chain"] = protein_chain;
Session["protein_atoms"] = protein_atoms;
Session["protein_residues"] = protein_residues;
Session["protein_residue_numbers"] = protein_residue_numbers;
Session["drug_atoms"] = drug_atoms;
LoadProtein(protein);
LoadDrug(drug, PDB);
LoadPDB_Info(PDB);
GetDrugAtomNumberingImage(drug);
CreateInteractionList(PDB, interaction_distance, protein_chain, protein_atoms, protein_residues, protein_residue_numbers, drug_atoms);
CreateInteractionSummary();
ScriptManager.RegisterStartupScript(Page, GetType(), "D_3DViewer", "javascript:loadDrugLigand('" + drug.Drug_PDB_ID + "');", true);
ScriptManager.RegisterStartupScript(Page, GetType(), "PDB_3DViewer", "javascript:loadStage('" + drug.PDB_File_ID + "', '" + drug.Drug_PDB_ID + "');", true);
}
}
}
