public IDimension DimensionForStandardPKParameter(StandardPKParameter standardPKParameter)
{
switch (standardPKParameter)
{
case StandardPKParameter.Unknown:
return(Constants.Dimension.NO_DIMENSION);
case StandardPKParameter.C_max:
case StandardPKParameter.C_min:
case StandardPKParameter.C_trough:
return(DimensionByName(Constants.Dimension.MOLAR_CONCENTRATION));
case StandardPKParameter.C_max_norm:
case StandardPKParameter.C_min_norm:
case StandardPKParameter.C_trough_norm:
return(DimensionByName(Constants.Dimension.MASS_CONCENTRATION));
case StandardPKParameter.t_max:
case StandardPKParameter.t_min:
case StandardPKParameter.Tthreshold:
case StandardPKParameter.MRT:
case StandardPKParameter.Thalf:
return(DimensionByName(Constants.Dimension.TIME));
case StandardPKParameter.AUC_tEnd:
case StandardPKParameter.AUC_inf:
case StandardPKParameter.AUC_tEnd_inf:
return(DimensionByName(Constants.Dimension.MOLAR_AUC));
case StandardPKParameter.AUC_tEnd_norm:
case StandardPKParameter.AUC_inf_norm:
case StandardPKParameter.AUC_tEnd_inf_norm:
return(DimensionByName(Constants.Dimension.MASS_AUC));
case StandardPKParameter.AUCM_tEnd:
return(DimensionByName(Constants.Dimension.MOLAR_AUCM));
case StandardPKParameter.FractionAucEndToInf:
return(DimensionByName(Constants.Dimension.FRACTION));
case StandardPKParameter.Vss:
case StandardPKParameter.Vd:
return(DimensionByName(Constants.Dimension.VOLUME_PER_BODY_WEIGHT));
default:
throw new ArgumentOutOfRangeException(nameof(standardPKParameter), standardPKParameter, null);
}
}
public UserDefinedPKParameter CreateUserDefinedPKParameter(
string name,
StandardPKParameter standardPKParameter,
string displayName,
string displayUnit)
{
var defaultDimension = _dimensionTask.DimensionForStandardPKParameter(standardPKParameter);
var userDefinedPKParameters = new UserDefinedPKParameter
{
Name = name,
DisplayName = displayName,
Dimension = defaultDimension,
DisplayUnit = displayUnit,
StandardPKParameter = standardPKParameter
};
//No display unit defined, we return the user defined pk parameter
if (string.IsNullOrEmpty(displayUnit))
{
return(userDefinedPKParameters);
}
var dimensionForDisplayUnit = _dimensionTask.DimensionForUnit(displayUnit);
//Display unit belongs to the dimension. We can use this
if (Equals(defaultDimension, dimensionForDisplayUnit))
{
return(userDefinedPKParameters);
}
//We have two dimensions. Do we have a converter between those dimensions?
if (_dimensionFactory.HasMergingInformation(defaultDimension, dimensionForDisplayUnit))
{
return(userDefinedPKParameters);
}
//There is no converter defined between those dimensions.
//We use the dimension defined for the display unit or create a user defined dimension otherwise
userDefinedPKParameters.Dimension = dimensionForDisplayUnit ?? _dimensionFactory.CreateUserDefinedDimension(name, displayUnit);
return(userDefinedPKParameters);
}
public double ValueFor(StandardPKParameter standardPKParameter, double?normalizationFactor)
{
Calculate();
var value = getPKParameterValue();
return(normalizationFactor.HasValue ? normalizedValue(value, normalizationFactor) : value);
double getPKParameterValue()
{
switch (standardPKParameter)
{
case StandardPKParameter.C_max:
return(Cmax);
case StandardPKParameter.C_max_norm:
return(doseNormalizedValue(Cmax));
case StandardPKParameter.t_max:
return(Tmax);
case StandardPKParameter.C_trough:
return(CTrough);
case StandardPKParameter.C_trough_norm:
return(doseNormalizedValue(CTrough));
case StandardPKParameter.AUC_tEnd:
return(AucTend);
case StandardPKParameter.AUC_tEnd_norm:
return(doseNormalizedValue(AucTend));
case StandardPKParameter.AUCM_tEnd:
return(AucmTend);
case StandardPKParameter.AUC_inf:
return(AucInf);
case StandardPKParameter.AUC_inf_norm:
return(doseNormalizedValue(AucInf));
case StandardPKParameter.AUC_tEnd_inf:
return(AucTendInf);
case StandardPKParameter.AUC_tEnd_inf_norm:
return(doseNormalizedValue(AucTendInf));
case StandardPKParameter.MRT:
return(Mrt);
case StandardPKParameter.CL:
return(CL);
case StandardPKParameter.FractionAucEndToInf:
return(FractionAucEndToInf);
case StandardPKParameter.Thalf:
return(Thalf);
case StandardPKParameter.Vss:
return(Vss);
case StandardPKParameter.Vd:
return(Vd);
case StandardPKParameter.Tthreshold:
return(Tthreshold);
case StandardPKParameter.C_min:
return(Cmin);
case StandardPKParameter.C_min_norm:
return(doseNormalizedValue(Cmin));
case StandardPKParameter.t_min:
return(Tmin);
case StandardPKParameter.Unknown:
return(NaN);
default:
throw new ArgumentOutOfRangeException(nameof(standardPKParameter), standardPKParameter, null);
}
}
}
