public DocumentSettingsDlg(IDocumentContainer documentContainer)
{
InitializeComponent();
Icon = Resources.Skyline;
DocumentContainer = documentContainer;
_annotationsListBoxDriver = new SettingsListBoxDriver<AnnotationDef>(
checkedListBoxAnnotations, Settings.Default.AnnotationDefList);
_annotationsListBoxDriver.LoadList(
DocumentContainer.Document.Settings.DataSettings.AnnotationDefs);
_groupComparisonsListBoxDriver = new SettingsListBoxDriver<GroupComparisonDef>(
checkedListBoxGroupComparisons, Settings.Default.GroupComparisonDefList);
_groupComparisonsListBoxDriver.LoadList(
DocumentContainer.Document.Settings.DataSettings.GroupComparisonDefs);
var dataSchema = new SkylineDataSchema(documentContainer, DataSchemaLocalizer.INVARIANT);
chooseViewsControl.ViewContext = new SkylineViewContext(dataSchema, new RowSourceInfo[0]);
chooseViewsControl.ShowCheckboxes = true;
chooseViewsControl.CheckedViews =
documentContainer.Document.Settings.DataSettings.ViewSpecList.ViewSpecs.Select(
viewSpec => PersistedViews.MainGroup.Id.ViewName(viewSpec.Name));
}
public ToolOptionsUI()
{
InitializeComponent();
checkBoxShowWizard.Checked = Settings.Default.ShowStartupForm;
powerOfTenCheckBox.Checked = Settings.Default.UsePowerOfTen;
Icon = Resources.Skyline;
_driverServers = new SettingsListBoxDriver <Server>(listboxServers, Settings.Default.ServerList);
_driverServers.LoadList();
_driverChorusAccounts = new SettingsListBoxDriver <RemoteAccount>(listBoxRemoteAccounts, Settings.Default.RemoteAccountList);
_driverChorusAccounts.LoadList();
_driverColorSchemes = new SettingsListComboDriver <ColorScheme>(comboColorScheme, Settings.Default.ColorSchemes, true);
_driverColorSchemes.LoadList(Settings.Default.CurrentColorScheme);
// Hide ability to turn off live reports
//tabControl.TabPages.Remove(tabMisc);
// Populate the languages list with the languages that Skyline has been localized to
string defaultDisplayName = string.Format(Resources.ToolOptionsUI_ToolOptionsUI_Default___0__,
CultureUtil.GetDisplayLanguage(CultureInfo.InstalledUICulture).DisplayName);
listBoxLanguages.Items.Add(new DisplayLanguageItem(string.Empty, defaultDisplayName));
foreach (var culture in CultureUtil.AvailableDisplayLanguages())
{
listBoxLanguages.Items.Add(new DisplayLanguageItem(culture.Name, culture.DisplayName));
}
for (int i = 0; i < listBoxLanguages.Items.Count; i++)
{
var displayLanguageItem = (DisplayLanguageItem)listBoxLanguages.Items[i];
if (Equals(displayLanguageItem.Key, Settings.Default.DisplayLanguage))
{
listBoxLanguages.SelectedIndex = i;
}
}
comboCompactFormatOption.Items.AddRange(CompactFormatOption.ALL_VALUES.ToArray());
comboCompactFormatOption.SelectedItem = CompactFormatOption.FromSettings();
}
public ToolOptionsUI()
{
InitializeComponent();
checkBoxShowWizard.Checked = Settings.Default.ShowStartupForm;
powerOfTenCheckBox.Checked = Settings.Default.UsePowerOfTen;
Icon = Resources.Skyline;
_driverServers = new SettingsListBoxDriver<Server>(listboxServers, Settings.Default.ServerList);
_driverServers.LoadList();
_driverChorusAccounts = new SettingsListBoxDriver<ChorusAccount>(listBoxChorusAccounts, Settings.Default.ChorusAccountList);
_driverChorusAccounts.LoadList();
// Hide ability to turn off live reports
//tabControl.TabPages.Remove(tabMisc);
// Populate the languages list with the languages that Skyline has been localized to
string defaultDisplayName = string.Format(Resources.ToolOptionsUI_ToolOptionsUI_Default___0__,
CultureUtil.GetDisplayLanguage(CultureInfo.InstalledUICulture).DisplayName);
listBoxLanguages.Items.Add(new DisplayLanguageItem(string.Empty, defaultDisplayName));
foreach (var culture in CultureUtil.AvailableDisplayLanguages())
{
listBoxLanguages.Items.Add(new DisplayLanguageItem(culture.Name, culture.DisplayName));
}
for (int i = 0; i < listBoxLanguages.Items.Count; i++)
{
var displayLanguageItem = (DisplayLanguageItem) listBoxLanguages.Items[i];
if (Equals(displayLanguageItem.Key, Settings.Default.DisplayLanguage))
{
listBoxLanguages.SelectedIndex = i;
}
}
if (!Settings.Default.EnableChorus)
{
tabControl.TabPages.Remove(tabChorus);
}
}
public ToolOptionsUI(SrmSettings settings)
{
InitializeComponent();
checkBoxShowWizard.Checked = Settings.Default.ShowStartupForm;
powerOfTenCheckBox.Checked = Settings.Default.UsePowerOfTen;
Icon = Resources.Skyline;
_driverServers = new SettingsListBoxDriver <Server>(listboxServers, Settings.Default.ServerList);
_driverServers.LoadList();
_driverRemoteAccounts = new SettingsListBoxDriver <RemoteAccount>(listBoxRemoteAccounts, Settings.Default.RemoteAccountList);
_driverRemoteAccounts.LoadList();
_driverColorSchemes = new SettingsListComboDriver <ColorScheme>(comboColorScheme, Settings.Default.ColorSchemes, true);
_driverColorSchemes.LoadList(Settings.Default.CurrentColorScheme);
var pingPep = new Peptide(@"PING");
var peptide = new PeptideDocNode(pingPep);
var precursor = new TransitionGroupDocNode(new TransitionGroup(pingPep, Adduct.SINGLY_PROTONATED, IsotopeLabelType.light),
new TransitionDocNode[0]);
_pingInput = new PrositIntensityModel.PeptidePrecursorNCE(peptide, precursor, IsotopeLabelType.light, 32);
_settingsNoMod = settings.ChangePeptideModifications(
pm => new PeptideModifications(new StaticMod[0], new TypedModifications[0]));
// Hide ability to turn off live reports
//tabControl.TabPages.Remove(tabMisc);
// Populate the languages list with the languages that Skyline has been localized to
string defaultDisplayName = string.Format(Resources.ToolOptionsUI_ToolOptionsUI_Default___0__,
CultureUtil.GetDisplayLanguage(CultureInfo.InstalledUICulture).DisplayName);
listBoxLanguages.Items.Add(new DisplayLanguageItem(string.Empty, defaultDisplayName));
foreach (var culture in CultureUtil.AvailableDisplayLanguages())
{
listBoxLanguages.Items.Add(new DisplayLanguageItem(culture.Name, culture.DisplayName));
}
for (int i = 0; i < listBoxLanguages.Items.Count; i++)
{
var displayLanguageItem = (DisplayLanguageItem)listBoxLanguages.Items[i];
if (Equals(displayLanguageItem.Key, Settings.Default.DisplayLanguage))
{
listBoxLanguages.SelectedIndex = i;
}
}
comboCompactFormatOption.Items.AddRange(CompactFormatOption.ALL_VALUES.ToArray());
comboCompactFormatOption.SelectedItem = CompactFormatOption.FromSettings();
var iModels = PrositIntensityModel.Models.ToList();
iModels.Insert(0, string.Empty);
var rtModels = PrositRetentionTimeModel.Models.ToList();
rtModels.Insert(0, string.Empty);
tbxPrositServer.Text = PrositConfig.GetPrositConfig().Server;
intensityModelCombo.Items.AddRange(iModels.ToArray());
iRTModelCombo.Items.AddRange(rtModels.ToArray());
prositServerStatusLabel.Text = string.Empty;
if (iModels.Contains(Settings.Default.PrositIntensityModel))
{
intensityModelCombo.SelectedItem = Settings.Default.PrositIntensityModel;
}
if (rtModels.Contains(Settings.Default.PrositRetentionTimeModel))
{
iRTModelCombo.SelectedItem = Settings.Default.PrositRetentionTimeModel;
}
ceCombo.Items.AddRange(
Enumerable.Range(PrositConstants.MIN_NCE, PrositConstants.MAX_NCE - PrositConstants.MIN_NCE + 1).Select(c => (object)c)
.ToArray());
ceCombo.SelectedItem = Settings.Default.PrositNCE;
}
public PeptideSettingsUI(SkylineWindow parent, LibraryManager libraryManager)
{
InitializeComponent();
btnUpdateIonMobilityLibraries.Visible = false; // TODO: ion mobility libraries are more complex than initially thought - put this off until after summer 2014 release
_parent = parent;
_libraryManager = libraryManager;
_peptideSettings = parent.DocumentUI.Settings.PeptideSettings;
// Initialize digestion settings
_driverEnzyme = new SettingsListComboDriver<Enzyme>(comboEnzyme, Settings.Default.EnzymeList);
_driverEnzyme.LoadList(_peptideSettings.Enzyme.GetKey());
for (int i = DigestSettings.MIN_MISSED_CLEAVAGES; i <= DigestSettings.MAX_MISSED_CLEAVAGES; i++)
comboMissedCleavages.Items.Add(i.ToString(CultureInfo.InvariantCulture));
comboMissedCleavages.SelectedItem = Digest.MaxMissedCleavages.ToString(LocalizationHelper.CurrentCulture);
if (comboMissedCleavages.SelectedIndex < 0)
comboMissedCleavages.SelectedIndex = 0;
cbRaggedEnds.Checked = Digest.ExcludeRaggedEnds;
// Initialize prediction settings
_driverRT = new SettingsListComboDriver<RetentionTimeRegression>(comboRetentionTime, Settings.Default.RetentionTimeList);
string sel = (Prediction.RetentionTime == null ? null : Prediction.RetentionTime.Name);
_driverRT.LoadList(sel);
cbUseMeasuredRT.Checked = textMeasureRTWindow.Enabled = Prediction.UseMeasuredRTs;
if (Prediction.MeasuredRTWindow.HasValue)
textMeasureRTWindow.Text = Prediction.MeasuredRTWindow.Value.ToString(LocalizationHelper.CurrentCulture);
_driverDT = new SettingsListComboDriver<DriftTimePredictor>(comboDriftTimePredictor, Settings.Default.DriftTimePredictorList);
string selDT = (Prediction.DriftTimePredictor == null ? null : Prediction.DriftTimePredictor.Name);
_driverDT.LoadList(selDT);
cbUseSpectralLibraryDriftTimes.Checked = textSpectralLibraryDriftTimesResolvingPower.Enabled = Prediction.UseLibraryDriftTimes;
if (Prediction.LibraryDriftTimesResolvingPower.HasValue)
textSpectralLibraryDriftTimesResolvingPower.Text = Prediction.LibraryDriftTimesResolvingPower.Value.ToString(LocalizationHelper.CurrentCulture);
// Initialize filter settings
_driverExclusion = new SettingsListBoxDriver<PeptideExcludeRegex>(listboxExclusions, Settings.Default.PeptideExcludeList);
_driverExclusion.LoadList(null, Filter.Exclusions);
textExcludeAAs.Text = Filter.ExcludeNTermAAs.ToString(LocalizationHelper.CurrentCulture);
textMaxLength.Text = Filter.MaxPeptideLength.ToString(LocalizationHelper.CurrentCulture);
textMinLength.Text = Filter.MinPeptideLength.ToString(LocalizationHelper.CurrentCulture);
cbAutoSelect.Checked = Filter.AutoSelect;
// Initialize spectral library settings
_driverLibrary = new SettingsListBoxDriver<LibrarySpec>(listLibraries, Settings.Default.SpectralLibraryList);
IList<LibrarySpec> listLibrarySpecs = Libraries.LibrarySpecs;
_driverLibrary.LoadList(null, listLibrarySpecs);
_driverBackgroundProteome = new SettingsListComboDriver<BackgroundProteomeSpec>(comboBackgroundProteome, Settings.Default.BackgroundProteomeList);
_driverBackgroundProteome.LoadList(_peptideSettings.BackgroundProteome.Name);
panelPick.Visible = listLibrarySpecs.Count > 0;
btnExplore.Enabled = listLibraries.Items.Count > 0;
comboMatching.SelectedIndex = (int) Libraries.Pick;
_lastRankId = Libraries.RankId;
_lastPeptideCount = Libraries.PeptideCount.HasValue
? Libraries.PeptideCount.Value.ToString(LocalizationHelper.CurrentCulture)
: null;
UpdateRanks(null);
// Initialize modification settings
_driverStaticMod = new SettingsListBoxDriver<StaticMod>(listStaticMods, Settings.Default.StaticModList);
_driverStaticMod.LoadList(null, Modifications.StaticModifications);
_driverHeavyMod = new SettingsListBoxDriver<StaticMod>(listHeavyMods, Settings.Default.HeavyModList);
_driverLabelType = new LabelTypeComboDriver(comboLabelType, Modifications, _driverHeavyMod,
labelStandardType, comboStandardType, listStandardTypes);
textMaxVariableMods.Text = Modifications.MaxVariableMods.ToString(LocalizationHelper.CurrentCulture);
textMaxNeutralLosses.Text = Modifications.MaxNeutralLosses.ToString(LocalizationHelper.CurrentCulture);
// Initialize peak scoring settings.
_driverPeakScoringModel = new SettingsListComboDriver<PeakScoringModelSpec>(comboPeakScoringModel, Settings.Default.PeakScoringModelList);
var peakScoringModel = _peptideSettings.Integration.PeakScoringModel;
_driverPeakScoringModel.LoadList(peakScoringModel != null ? peakScoringModel.Name : null);
IsShowLibraryExplorer = false;
tabControl1.TabPages.Remove(tabIntegration);
comboNormalizationMethod.Items.AddRange(
NormalizationMethod.ListNormalizationMethods(parent.DocumentUI).ToArray());
comboNormalizationMethod.SelectedItem = _peptideSettings.Quantification.NormalizationMethod;
comboWeighting.Items.AddRange(RegressionWeighting.All.Cast<object>().ToArray());
comboWeighting.SelectedItem = _peptideSettings.Quantification.RegressionWeighting;
comboRegressionFit.Items.AddRange(RegressionFit.All.Cast<object>().ToArray());
comboRegressionFit.SelectedItem = _peptideSettings.Quantification.RegressionFit;
comboQuantMsLevel.SelectedIndex = Math.Max(0, _quantMsLevels.IndexOf(_peptideSettings.Quantification.MsLevel));
tbxQuantUnits.Text = _peptideSettings.Quantification.Units;
}
public RefineDlg(IDocumentUIContainer documentContainer)
{
_document = documentContainer.DocumentUI;
_settings = documentContainer.DocumentUI.Settings;
DocumentContainer = documentContainer;
InitializeComponent();
Icon = Resources.Skyline;
// Save text for later use
_removeLabelText = labelLabelType.Text;
_removeTipText = helpTip.GetToolTip(comboRefineLabelType);
// Fill label type comb_o box
comboRefineLabelType.Items.Add(string.Empty);
comboRefineLabelType.Items.Add(IsotopeLabelType.LIGHT_NAME);
foreach (var typedMods in _settings.PeptideSettings.Modifications.GetHeavyModifications())
{
comboRefineLabelType.Items.Add(typedMods.LabelType.Name);
}
comboRefineLabelType.SelectedIndex = 0;
comboReplicateUse.SelectedIndex = 0;
if (!_settings.HasResults)
{
FormUtil.RemoveTabPage(tabResults, helpTip);
}
if (!_settings.HasResults || _settings.MeasuredResults.Chromatograms.Count < 2)
{
FormUtil.RemoveTabPage(tabConsistency, helpTip);
}
else
{
// Consistency tab
textQVal.Enabled = _settings.PeptideSettings.Integration.PeakScoringModel.IsTrained;
numericUpDownDetections.Enabled = textQVal.Enabled;
if (numericUpDownDetections.Enabled)
{
numericUpDownDetections.Minimum = 1;
numericUpDownDetections.Maximum = _document.MeasuredResults.Chromatograms.Count;
numericUpDownDetections.Value = 1;
}
_normalizationMethods.Clear();
_normalizationMethods.Add(NormalizeOption.DEFAULT);
_normalizationMethods.AddRange(NormalizeOption.AvailableNormalizeOptions(_document));
_normalizationMethods.Add(NormalizeOption.NONE);
comboNormalizeTo.Items.Clear();
comboNormalizeTo.Items.AddRange(_normalizationMethods.Select(option => option.Caption).ToArray());
comboNormalizeTo.SelectedIndex = comboNormalizeTo.Items.Count - 1;
comboTransitions.Items.Add(Resources.RefineDlg_RefineDlg_all);
comboTransitions.Items.Add(Resources.RefineDlg_RefineDlg_best);
comboTransitions.SelectedIndex = 0;
var maxTrans = _document.MoleculeTransitionGroups.Select(g => g.TransitionCount).DefaultIfEmpty().Max();
for (int i = 1; i <= maxTrans; i++)
{
comboTransitions.Items.Add(i);
}
if (_document.MoleculeTransitions.Any(t => t.IsMs1))
{
comboTransType.Items.Add(Resources.RefineDlg_RefineDlg_Precursors);
comboTransType.SelectedIndex = comboTransType.Items.Count - 1;
}
if (_document.MoleculeTransitions.Any(t => !t.IsMs1))
{
comboTransType.Items.Add(Resources.RefineDlg_RefineDlg_Products);
comboTransType.SelectedIndex = comboTransType.Items.Count - 1;
}
if (comboTransType.Items.Count == 1)
{
comboTransType.Enabled = false;
}
}
if (_settings.PeptideSettings.Libraries.HasLibraries)
{
labelMinDotProduct.Enabled = textMinDotProduct.Enabled = groupLibCorr.Enabled = true;
}
if (_settings.TransitionSettings.FullScan.IsHighResPrecursor)
{
labelMinIdotProduct.Enabled = textMinIdotProduct.Enabled = groupLibCorr.Enabled = true;
}
// Group Comparisons
_groupComparisonsListBoxDriver = new SettingsListBoxDriver <GroupComparisonDef>(
checkedListBoxGroupComparisons, Settings.Default.GroupComparisonDefList);
_groupComparisonsListBoxDriver.LoadList(
_document.Settings.DataSettings.GroupComparisonDefs);
if (_document.PeptideTransitions.Any(t => t.IsMs1))
{
comboMSGroupComparisons.Items.Add(Resources.RefineDlg_MSLevel_1);
comboMSGroupComparisons.SelectedIndex = comboMSGroupComparisons.Items.Count - 1;
}
if (_document.PeptideTransitions.Any(t => !t.IsMs1))
{
comboMSGroupComparisons.Items.Add(Resources.RefineDlg_MSLevel_2);
comboMSGroupComparisons.SelectedIndex = comboMSGroupComparisons.Items.Count - 1;
}
if (comboMSGroupComparisons.Items.Count == 1)
{
comboMSGroupComparisons.Enabled = false;
}
}
public TransitionSettingsUI(SkylineWindow parent)
{
InitializeComponent();
// Populate the fragment finder combo boxes
foreach (string item in TransitionFilter.GetStartFragmentFinderLabels())
comboRangeFrom.Items.Add(item);
foreach (string item in TransitionFilter.GetEndFragmentFinderLabels())
comboRangeTo.Items.Add(item);
_parent = parent;
_transitionSettings = _parent.DocumentUI.Settings.TransitionSettings;
// Initialize prediction settings
comboPrecursorMass.SelectedItem = Prediction.PrecursorMassType.GetLocalizedString();
comboIonMass.SelectedItem = Prediction.FragmentMassType.GetLocalizedString();
_driverCE = new SettingsListComboDriver<CollisionEnergyRegression>(comboCollisionEnergy,
Settings.Default.CollisionEnergyList);
string sel = (Prediction.CollisionEnergy == null ? null : Prediction.CollisionEnergy.Name);
_driverCE.LoadList(sel);
_driverDP = new SettingsListComboDriver<DeclusteringPotentialRegression>(comboDeclusterPotential,
Settings.Default.DeclusterPotentialList);
sel = (Prediction.DeclusteringPotential == null ? null : Prediction.DeclusteringPotential.Name);
_driverDP.LoadList(sel);
_driverCoV = new SettingsListComboDriver<CompensationVoltageParameters>(comboCompensationVoltage,
Settings.Default.CompensationVoltageList);
_driverCoV.LoadList(Prediction.CompensationVoltage == null ? null : Prediction.CompensationVoltage.Name);
_driverOptimizationLibrary = new SettingsListComboDriver<OptimizationLibrary>(comboOptimizationLibrary,
Settings.Default.OptimizationLibraryList);
_driverOptimizationLibrary.LoadList(Prediction.OptimizedLibrary == null ? null : Prediction.OptimizedLibrary.Name);
if (Prediction.OptimizedMethodType == OptimizedMethodType.None)
comboOptimizeType.SelectedIndex = 0;
else
{
cbUseOptimized.Checked = true;
comboOptimizeType.SelectedItem = Prediction.OptimizedMethodType.GetLocalizedString();
}
// Initialize filter settings
textPrecursorCharges.Text = Filter.PrecursorCharges.ToArray().ToString(", "); // Not L10N? Internationalization of comma?
textIonCharges.Text = Filter.ProductCharges.ToArray().ToString(", "); // Not L10N? Internationalization of comma?
textIonTypes.Text = TransitionFilter.ToStringIonTypes(Filter.IonTypes, true);
comboRangeFrom.SelectedItem = Filter.FragmentRangeFirst.Label;
comboRangeTo.SelectedItem = Filter.FragmentRangeLast.Label;
textExclusionWindow.Text = Filter.PrecursorMzWindow != 0
? Filter.PrecursorMzWindow.ToString(LocalizationHelper.CurrentCulture)
: string.Empty;
cbExclusionUseDIAWindow.Checked = Filter.ExclusionUseDIAWindow;
cbAutoSelect.Checked = Filter.AutoSelect;
_driverIons = new MeasuredIonListBoxDriver(listAlwaysAdd, Settings.Default.MeasuredIonList);
_driverIons.LoadList(Filter.MeasuredIons);
// Initialize library settings
cbLibraryPick.Checked = (Libraries.Pick != TransitionLibraryPick.none);
panelPick.Visible = cbLibraryPick.Checked;
textTolerance.Text = Libraries.IonMatchTolerance.ToString(LocalizationHelper.CurrentCulture);
textIonCount.Text = Libraries.IonCount.ToString(LocalizationHelper.CurrentCulture);
if (Libraries.Pick == TransitionLibraryPick.filter)
radioFiltered.Checked = true;
else if (Libraries.Pick == TransitionLibraryPick.all_plus)
radioAllAndFiltered.Checked = true;
// Initialize instrument settings
textMinMz.Text = Instrument.MinMz.ToString(LocalizationHelper.CurrentCulture);
textMaxMz.Text = Instrument.MaxMz.ToString(LocalizationHelper.CurrentCulture);
cbDynamicMinimum.Checked = Instrument.IsDynamicMin;
textMzMatchTolerance.Text = Instrument.MzMatchTolerance.ToString(LocalizationHelper.CurrentCulture);
if (Instrument.MaxTransitions.HasValue)
textMaxTrans.Text = Instrument.MaxTransitions.Value.ToString(LocalizationHelper.CurrentCulture);
if (Instrument.MaxInclusions.HasValue)
textMaxInclusions.Text = Instrument.MaxInclusions.Value.ToString(LocalizationHelper.CurrentCulture);
if (Instrument.MinTime.HasValue)
textMinTime.Text = Instrument.MinTime.Value.ToString(LocalizationHelper.CurrentCulture);
if (Instrument.MaxTime.HasValue)
textMaxTime.Text = Instrument.MaxTime.Value.ToString(LocalizationHelper.CurrentCulture);
// Initialize full-scan settings
FullScanSettingsControl = new FullScanSettingsControl(_parent)
{
Anchor = (AnchorStyles.Top | AnchorStyles.Left),
Location = new Point(0, 0),
Size = new Size(363, 491)
};
FullScanSettingsControl.IsolationSchemeChangedEvent += IsolationSchemeChanged;
tabFullScan.Controls.Add(FullScanSettingsControl);
// VISUAL:
// - Store the distance between the cbExclusionDIAWindow and the lower end of the box (to use as margin later)
// - Shift the cbExclusionDIAWindow down (it is only higher in the designer for better manipulation)
_lower_margin = groupBox1.Height - textExclusionWindow.Location.Y - textExclusionWindow.Height;
int pixelShift = cbExclusionUseDIAWindow.Location.Y - lbPrecursorMzWindow.Location.Y;
cbExclusionUseDIAWindow.Location = new Point(cbExclusionUseDIAWindow.Location.X, cbExclusionUseDIAWindow.Location.Y - pixelShift);
DoIsolationSchemeChanged();
}