private void setSingleDosingPKValues(ICache <string, double> pk, PKInterval interval)
{
setCmaxAndTmax(pk, interval, Constants.PKParameters.C_max, Constants.PKParameters.Tmax);
setValue(pk, Constants.PKParameters.C_tEnd, interval, x => x.CTrough);
setValueAndNormalize(pk, Constants.PKParameters.AUC_tEnd, interval, x => x.AucTend);
setValueAndNormalize(pk, Constants.PKParameters.AUC_inf, interval, x => x.AucInf);
setValue(pk, Constants.PKParameters.Thalf, interval, x => x.Thalf);
setValue(pk, Constants.PKParameters.MRT, interval, x => x.Mrt);
setValue(pk, Constants.PKParameters.FractionAucEndToInf, interval, x => x.FractionAucEndToInf);
setValue(pk, Constants.PKParameters.CL, interval, x => x.CL);
setValue(pk, Constants.PKParameters.Vss, interval, x => x.Vss);
setValue(pk, Constants.PKParameters.Vd, interval, x => x.Vd);
}
private IReadOnlyList <PKInterval> allStandardIntervalsFor(List <float> time, List <float> concentration, PKCalculationOptions options)
{
var fullRange = new PKInterval(time, concentration, options, drugMassPerBodyWeight: options.TotalDrugMassPerBodyWeight);
//only one interval, return the full range
if (options.SingleDosing)
{
return new[] { fullRange }
}
;
//Two or more intervals
var intervals = new[]
{
pkIntervalFromDosingInterval(options.FirstInterval, time, concentration, options),
pkIntervalFromDosingInterval(options.LastMinusOneInterval, time, concentration, options),
pkIntervalFromDosingInterval(options.LastInterval, time, concentration, options),
fullRange
};
return(intervals.Where(x => x != null).ToList());
}
private void setValue(ICache <string, double> pk, string parameterName, PKInterval pkInterval, Func <PKInterval, double> valueFunc)
{
setValue(pk, parameterName, valueFunc(pkInterval));
}
private void setValueAndNormalize(ICache <string, double> pk, string parameterName, PKInterval pkInterval, Func <PKInterval, double> valueFunc)
{
setValue(pk, parameterName, pkInterval, valueFunc);
pk[Constants.PKParameters.NormalizedName(parameterName)] = pkInterval.NormalizeValue(valueFunc);
}
private void setCmaxAndTmax(ICache <string, double> pk, PKInterval interval, string cmaxName, string tMaxName)
{
setValueAndNormalize(pk, cmaxName, interval, x => x.Cmax);
setValue(pk, tMaxName, interval, x => x.Tmax);
}
