protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_compoundProperties, _project);
// Adds an incorrect compound process selection
_snapshot.Processes = new List <CompoundProcessSelection>(_snapshot.Processes)
{
new CompoundProcessSelection()
}.ToArray();
_simulation = A.Fake <Simulation>();
_simulationSubject = A.Fake <ISimulationSubject>();
A.CallTo(() => _simulationSubject.MoleculeByName("CYP3A4")).Returns(new IndividualEnzyme {
Name = "CYP3A4"
});
A.CallTo(() => _simulation.BuildingBlock <ISimulationSubject>()).Returns(_simulationSubject);
var newModelCompoundProperties = new Model.CompoundProperties {
Compound = _compoundProperties.Compound
};
_compoundProperties.CompoundGroupSelections.Each(newModelCompoundProperties.AddCompoundGroupSelection);
A.CallTo(() => _simulation.CompoundPropertiesFor(_snapshot.Name)).Returns(newModelCompoundProperties);
_context = new CompoundPropertiesContext(_project, _simulation);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_compoundProperties, _project);
_simulation = A.Fake <Simulation>();
var newModelCompoundProperties = new Model.CompoundProperties {
Compound = _compoundProperties.Compound
};
_compoundProperties.CompoundGroupSelections.Each(newModelCompoundProperties.AddCompoundGroupSelection);
A.CallTo(() => _simulation.CompoundPropertiesFor(_snapshot.Name)).Returns(newModelCompoundProperties);
_context = new CompoundPropertiesContext(_project, _simulation);
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_compoundProperties, _project);
_simulation = A.Fake <Simulation>();
var newModelCompoundProperties = new Model.CompoundProperties {
Compound = _compoundProperties.Compound
};
_compoundProperties.CompoundGroupSelections.Each(newModelCompoundProperties.AddCompoundGroupSelection);
A.CallTo(() => _simulation.CompoundPropertiesFor(_snapshot.Name)).Returns(newModelCompoundProperties);
_context = new SnapshotContextWithSimulation(_simulation, _baseSnapshotContext);
_snapshot.Alternatives[0].AlternativeName = "UNKNOWN";
}
protected override async Task Context()
{
await base.Context();
_snapshot = await sut.MapToSnapshot(_compoundProperties, _project);
_simulation = A.Fake <Simulation>();
_simulationSubject = A.Fake <ISimulationSubject>();
A.CallTo(() => _simulationSubject.MoleculeByName("CYP3A4")).Returns(null);
A.CallTo(() => _simulation.BuildingBlock <ISimulationSubject>()).Returns(_simulationSubject);
var newModelCompoundProperties = new Model.CompoundProperties {
Compound = _compoundProperties.Compound
};
_compoundProperties.CompoundGroupSelections.Each(newModelCompoundProperties.AddCompoundGroupSelection);
A.CallTo(() => _simulation.CompoundPropertiesFor(_snapshot.Name)).Returns(newModelCompoundProperties);
_context = new SnapshotContextWithSimulation(_simulation, _baseSnapshotContext);
}
protected override Task Context()
{
_calculationMethodCacheMapper = A.Fake <CalculationMethodCacheMapper>();
_processMappingMapper = A.Fake <ProcessMappingMapper>();
_logger = A.Fake <ILogger>();
_project = new PKSimProject();
_calculationMethodSnapshot = new CalculationMethodCache();
sut = new CompoundPropertiesMapper(_calculationMethodCacheMapper, _processMappingMapper, _logger);
_compoundGroupSelectionOneAlternative = new CompoundGroupSelection
{
AlternativeName = "ALT1",
GroupName = "ALTERNATIVE_GROUP_1"
};
_compoundGroupSelectionTwoAlternatives = new CompoundGroupSelection
{
AlternativeName = "ALT2",
GroupName = "ALTERNATIVE_GROUP_2"
};
_compound = new Compound
{
Name = "COMP",
};
_protocol = new SimpleProtocol
{
Name = "PROTOCOL"
};
_parameterAlternativeGroupWithOneAlternative = new ParameterAlternativeGroup {
Name = _compoundGroupSelectionOneAlternative.GroupName
};
_parameterAlternativeGroupWithTwoAlternatives = new ParameterAlternativeGroup {
Name = _compoundGroupSelectionTwoAlternatives.GroupName
};
_parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative {
Name = "ALT1"
});
_parameterAlternativeGroupWithTwoAlternatives.AddAlternative(new ParameterAlternative {
Name = "ALT2"
});
_compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithOneAlternative);
_compound.AddParameterAlternativeGroup(_parameterAlternativeGroupWithTwoAlternatives);
_compoundProperties = new Model.CompoundProperties();
_compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionOneAlternative);
_compoundProperties.AddCompoundGroupSelection(_compoundGroupSelectionTwoAlternatives);
_compoundProperties.Compound = _compound;
_enzymaticProcess = new EnzymaticProcess {
Name = "EnzymaticProcess"
};
_anotherEnzymaticProcess = new EnzymaticProcess {
Name = "AnotherEnzymaticProcess", MoleculeName = "CYP3A4"
};
_specificBindingProcess = new SpecificBindingPartialProcess {
Name = "SpecificBinding"
};
_gfrTransportProcess = new SystemicProcess {
Name = "Transport", SystemicProcessType = SystemicProcessTypes.GFR
};
_hepaticEnzymaticProcess = new SystemicProcess {
Name = "Plasma Clearance", SystemicProcessType = SystemicProcessTypes.Hepatic
};
_compound.AddProcess(_enzymaticProcess);
_compound.AddProcess(_specificBindingProcess);
_compound.AddProcess(_gfrTransportProcess);
_compound.AddProcess(_hepaticEnzymaticProcess);
_enzymaticPartialProcessSelection = new EnzymaticProcessSelection {
ProcessName = _enzymaticProcess.Name
};
_noEnzymaticSystemicProcessSelection = new SystemicProcessSelection {
ProcessType = SystemicProcessTypes.Hepatic
};
_specificBindingPartialProcessSelection = new ProcessSelection {
ProcessName = _specificBindingProcess.Name
};
_transportSystemicProcessSelection = new SystemicProcessSelection {
ProcessName = _gfrTransportProcess.Name, ProcessType = _gfrTransportProcess.SystemicProcessType,
};
_noEnzymaticPartialProcessSelection = new EnzymaticProcessSelection {
MoleculeName = _anotherEnzymaticProcess.MoleculeName
};
_compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_enzymaticPartialProcessSelection);
_compoundProperties.Processes.MetabolizationSelection.AddPartialProcessSelection(_noEnzymaticPartialProcessSelection);
_compoundProperties.Processes.MetabolizationSelection.AddSystemicProcessSelection(_noEnzymaticSystemicProcessSelection);
_compoundProperties.Processes.SpecificBindingSelection.AddPartialProcessSelection(_specificBindingPartialProcessSelection);
_compoundProperties.Processes.TransportAndExcretionSelection.AddSystemicProcessSelection(_transportSystemicProcessSelection);
_snapshotProcess1 = new CompoundProcessSelection {
Name = _enzymaticPartialProcessSelection.ProcessName
};
_snapshotProcess2 = new CompoundProcessSelection {
Name = _specificBindingPartialProcessSelection.ProcessName
};
_snapshotProcess3 = new CompoundProcessSelection {
Name = _transportSystemicProcessSelection.ProcessName
};
_snapshotProcess4 = new CompoundProcessSelection {
SystemicProcessType = _noEnzymaticSystemicProcessSelection.ProcessType.SystemicProcessTypeId.ToString()
};
_snapshotProcess5 = new CompoundProcessSelection {
MoleculeName = _noEnzymaticPartialProcessSelection.MoleculeName
};
_formulation = new Formulation
{
Id = "123456"
};
_compoundProperties.ProtocolProperties.Protocol = _protocol;
_compoundProperties.ProtocolProperties.AddFormulationMapping(new FormulationMapping
{
FormulationKey = "F1",
TemplateFormulationId = _formulation.Id
});
_project.AddBuildingBlock(_formulation);
A.CallTo(() => _calculationMethodCacheMapper.MapToSnapshot(_compoundProperties.CalculationMethodCache)).Returns(_calculationMethodSnapshot);
A.CallTo(() => _processMappingMapper.MapToSnapshot(_enzymaticPartialProcessSelection)).Returns(_snapshotProcess1);
A.CallTo(() => _processMappingMapper.MapToSnapshot(_specificBindingPartialProcessSelection)).Returns(_snapshotProcess2);
A.CallTo(() => _processMappingMapper.MapToSnapshot(_transportSystemicProcessSelection)).Returns(_snapshotProcess3);
A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticSystemicProcessSelection)).Returns(_snapshotProcess4);
A.CallTo(() => _processMappingMapper.MapToSnapshot(_noEnzymaticPartialProcessSelection)).Returns(_snapshotProcess5);
A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess1, _enzymaticProcess)).Returns(_enzymaticPartialProcessSelection);
A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess2, _specificBindingProcess)).Returns(_specificBindingPartialProcessSelection);
A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess3, _gfrTransportProcess)).Returns(_transportSystemicProcessSelection);
A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess4, A <NotSelectedSystemicProcess> ._)).Returns(_noEnzymaticSystemicProcessSelection);
A.CallTo(() => _processMappingMapper.MapToModel(_snapshotProcess5, A <EnzymaticProcess> ._)).Returns(_noEnzymaticPartialProcessSelection);
return(_completed);
}
