public ProtocolChartPresenter(IProtocolChartView view,
IProtocolToSchemaItemsMapper schemaItemsMapper,
ISchemaItemToSchemaItemDTOMapper schemaItemDTOMapper,
IDimensionRepository dimensionRepository) : base(view)
{
_schemaItemsMapper = schemaItemsMapper;
_schemaItemDTOMapper = schemaItemDTOMapper;
_dimensionRepository = dimensionRepository;
}
protected override void Context()
{
_simulation = new IndividualSimulation
{
Properties = new SimulationProperties(),
SimulationSettings = new SimulationSettings(),
ModelConfiguration = new ModelConfiguration()
};
_individual = new Individual().WithName("MyIndividual");
_speciesPopulation = new SpeciesPopulation();
_individual.OriginData = new OriginData {
SpeciesPopulation = _speciesPopulation
};
_compound = A.Fake <Compound>().WithName("MyCompound");
_protocol = A.Fake <SimpleProtocol>().WithName("MyProtocol");
_formulation = A.Fake <Formulation>().WithName("Formulation");
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Individual", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Compound", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Protocol", PKSimBuildingBlockType.Protocol)
{
BuildingBlock = _protocol
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("Formulation", PKSimBuildingBlockType.Formulation)
{
BuildingBlock = _formulation
});
_protocolToProtocolSchemaItemMapper = A.Fake <IProtocolToSchemaItemsMapper>();
sut = new SimulationConfigurationValidator(_protocolToProtocolSchemaItemMapper);
_speciesPopulation.IsHeightDependent = false;
_schemaItem = A.Fake <SchemaItem>();
_doseUnit = A.Fake <Unit>();
_schemaItem.Dose.DisplayUnit = _doseUnit;
_protocolProperties = new ProtocolProperties();
_formulationMapping = new FormulationMapping {
FormulationKey = "F1", Formulation = _formulation
};
_simulation.Properties.AddCompoundProperties(new CompoundProperties
{
Compound = _compound,
ProtocolProperties = _protocolProperties
});
A.CallTo(() => _protocolToProtocolSchemaItemMapper.MapFrom(_protocol)).Returns(new [] { _schemaItem });
}
public ProtocolChartPresenter(
IProtocolChartView view,
IProtocolToSchemaItemsMapper schemaItemsMapper,
ISchemaItemToSchemaItemDTOMapper schemaItemDTOMapper,
IDimensionRepository dimensionRepository,
IApplicationSettings applicationSettings) : base(view)
{
_schemaItemsMapper = schemaItemsMapper;
_schemaItemDTOMapper = schemaItemDTOMapper;
_dimensionRepository = dimensionRepository;
_applicationSettings = applicationSettings;
}
public GlobalPKAnalysisTask(IParameterFactory parameterFactory, IProtocolToSchemaItemsMapper protocolToSchemaItemsMapper,
IProtocolFactory protocolFactory, IGlobalPKAnalysisRunner globalPKAnalysisRunner, IPKAnalysisTask pkAnalysisTask,
IPKCalculationOptionsFactory pkCalculationOptionsFactory, IVSSCalculator vssCalculator, IInteractionTask interactionTask, ICloner cloner)
{
_parameterFactory = parameterFactory;
_protocolToSchemaItemsMapper = protocolToSchemaItemsMapper;
_protocolFactory = protocolFactory;
_globalPKAnalysisRunner = globalPKAnalysisRunner;
_pkAnalysisTask = pkAnalysisTask;
_pkCalculationOptionsFactory = pkCalculationOptionsFactory;
_vssCalculator = vssCalculator;
_interactionTask = interactionTask;
_cloner = cloner;
}
public EventBuildingBlockCreator(IObjectBaseFactory objectBaseFactory,
IProtocolToSchemaItemsMapper schemaItemsMapper,
IApplicationFactory applicationFactory,
IFormulationFromMappingRetriever formulationFromMappingRetriever,
ICloneManagerForBuildingBlock cloneManagerForBuildingBlock,
IParameterIdUpdater parameterIdUpdater,
IParameterSetUpdater parameterSetUpdater,
IEventGroupRepository eventGroupRepository)
{
_objectBaseFactory = objectBaseFactory;
_schemaItemsMapper = schemaItemsMapper;
_applicationFactory = applicationFactory;
_formulationFromMappingRetriever = formulationFromMappingRetriever;
_cloneManagerForBuildingBlock = cloneManagerForBuildingBlock;
_parameterIdUpdater = parameterIdUpdater;
_parameterSetUpdater = parameterSetUpdater;
_eventGroupRepository = eventGroupRepository;
}
protected override void Context()
{
_vssCalculator = A.Fake <IVSSCalculator>();
_parameterFactory = A.Fake <IParameterFactory>();
_protocolMapper = A.Fake <IProtocolToSchemaItemsMapper>();
_protocolFactory = A.Fake <IProtocolFactory>();
_globalPKAnalysisRunner = A.Fake <IGlobalPKAnalysisRunner>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkAnalysisTask = A.Fake <IPKAnalysesTask>();
_interactionTask = A.Fake <IInteractionTask>();
_cloner = A.Fake <ICloner>();
sut = new GlobalPKAnalysisTask(_parameterFactory, _protocolMapper, _protocolFactory, _globalPKAnalysisRunner,
_pkAnalysisTask, _pkCalculationOptionsFactory, _vssCalculator, _interactionTask, _cloner);
var baseGrid = new BaseGrid("time", A.Fake <IDimension>());
_peripheralVenousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.PeripheralVenousBlood, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, _compoundName);
_venousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.VenousBlood, CoreConstants.Compartment.Plasma, CoreConstants.Observer.CONCENTRATION_IN_CONTAINER, _compoundName);
_individual = A.Fake <Individual>();
_species = new Species();
A.CallTo(() => _individual.Species).Returns(_species);
_compound = new Compound().WithName(_compoundName);
_compoundProperties = new CompoundProperties {
Compound = _compound
};
_simulationSchemaItems = new List <SchemaItem>();
_protocol = new SimpleProtocol();
_compoundProperties.ProtocolProperties.Protocol = _protocol;
A.CallTo(() => _protocolMapper.MapFrom(_protocol)).Returns(_simulationSchemaItems);
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_simulation.Properties.AddCompoundProperties(_compoundProperties);
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompId", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndividualId", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.DataRepository = new DataRepository {
_venousBloodPlasma, _peripheralVenousBloodPlasma
};
_venousBloodPK = new PKValues();
_venousBloodPK.AddValue(Constants.PKParameters.Vss, 10);
_venousBloodPK.AddValue(Constants.PKParameters.Vd, 11);
_venousBloodPK.AddValue(Constants.PKParameters.CL, 12);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 13);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 14);
_peripheralVenousBloodPK = new PKValues();
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vss, 21);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vd, 22);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.CL, 23);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 24);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 25);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max, 26);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max_tDLast_tDEnd, 27);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_venousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_venousBloodPK);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_peripheralVenousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_peripheralVenousBloodPK);
A.CallTo(() => _parameterFactory.CreateFor(A <string> ._, A <double> ._, A <string> ._, PKSimBuildingBlockType.Simulation))
.ReturnsLazily(s => new PKSimParameter().WithName((string)s.Arguments[0])
.WithDimension(A.Fake <IDimension>())
.WithFormula(new ConstantFormula((double)s.Arguments[1])));
}
public SimulationConfigurationValidator(IProtocolToSchemaItemsMapper schemaItemsMapper)
{
_schemaItemsMapper = schemaItemsMapper;
}
protected override void Context()
{
_vssCalculator = A.Fake <IVSSCalculator>();
_parameterFactory = A.Fake <IParameterFactory>();
_protocolMapper = A.Fake <IProtocolToSchemaItemsMapper>();
_protocolFactory = A.Fake <IProtocolFactory>();
_globalPKAnalysisRunner = A.Fake <IGlobalPKAnalysisRunner>();
_pkCalculationOptionsFactory = A.Fake <IPKCalculationOptionsFactory>();
_pkAnalysisTask = A.Fake <IPKAnalysesTask>();
_interactionTask = A.Fake <IInteractionTask>();
_cloner = A.Fake <ICloner>();
sut = new GlobalPKAnalysisTask(_parameterFactory, _protocolMapper, _protocolFactory, _globalPKAnalysisRunner,
_pkAnalysisTask, _pkCalculationOptionsFactory, _vssCalculator, _interactionTask, _cloner);
var baseGrid = new BaseGrid("time", A.Fake <IDimension>());
_peripheralVenousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, CoreConstants.Observer.PLASMA_PERIPHERAL_VENOUS_BLOOD, _compoundName);
_venousBloodPlasma = CalculationColumnFor(baseGrid, CoreConstants.Organ.VENOUS_BLOOD, CoreConstants.Compartment.PLASMA, CoreConstants.Observer.CONCENTRATION_IN_CONTAINER, _compoundName);
_individual = A.Fake <Individual>();
_species = new Species();
A.CallTo(() => _individual.Species).Returns(_species);
_compound = new Compound().WithName(_compoundName);
_compoundProperties = new CompoundProperties {
Compound = _compound
};
_protocol = new SimpleProtocol();
_compoundProperties.ProtocolProperties.Protocol = _protocol;
_simulation = new IndividualSimulation {
Properties = new SimulationProperties()
};
_simulation.Properties.AddCompoundProperties(_compoundProperties);
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("CompId", PKSimBuildingBlockType.Compound)
{
BuildingBlock = _compound
});
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock("IndividualId", PKSimBuildingBlockType.Individual)
{
BuildingBlock = _individual
});
_simulation.DataRepository = new DataRepository {
_venousBloodPlasma, _peripheralVenousBloodPlasma
};
_simulation.SimulationSettings = new SimulationSettings();
_simulation.OutputSchema = new OutputSchema();
_simulation.OutputSchema.AddInterval(new OutputInterval {
DomainHelperForSpecs.ConstantParameterWithValue(100).WithName(Constants.Parameters.END_TIME)
});
_simulation.Model = new OSPSuite.Core.Domain.Model {
Root = new Container()
};
_eventGroup = new EventGroup();
_application1 = new Container().WithName("App1").WithContainerType(ContainerType.Application);
_application1.Add(new MoleculeAmount().WithName(_compoundName));
_application1.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2 = new Container().WithName("App2").WithContainerType(ContainerType.Application);
_application2.Add(DomainHelperForSpecs.ConstantParameterWithValue(10).WithName(Constants.Parameters.START_TIME));
_application2.Add(new MoleculeAmount().WithName(_compoundName));
_simulation.Model.Root.Add(_eventGroup);
_eventGroup.Add(_application1);
_venousBloodPK = new PKValues();
_venousBloodPK.AddValue(Constants.PKParameters.Vss, 10);
_venousBloodPK.AddValue(Constants.PKParameters.Vd, 11);
_venousBloodPK.AddValue(Constants.PKParameters.CL, 12);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 13);
_venousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 14);
_peripheralVenousBloodPK = new PKValues();
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vss, 21);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.Vd, 22);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.CL, 23);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf, 24);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.AUC_inf_tD1_norm, 25);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max, 26);
_peripheralVenousBloodPK.AddValue(Constants.PKParameters.C_max_tDLast_tDEnd, 27);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_venousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_venousBloodPK);
A.CallTo(() => _pkAnalysisTask.CalculatePK(_peripheralVenousBloodPlasma, A <PKCalculationOptions> ._)).Returns(_peripheralVenousBloodPK);
A.CallTo(() => _parameterFactory.CreateFor(A <string> ._, A <double> ._, A <string> ._, PKSimBuildingBlockType.Simulation))
.ReturnsLazily(s => new PKSimParameter().WithName((string)s.Arguments[0])
.WithDimension(A.Fake <IDimension>())
.WithFormula(new ConstantFormula((double)s.Arguments[1])));
}
