// SAME FUNCTION FOR USE WITH SimulationManager3...
void signal(simulationManager3 mngr)
{
signalReleased = true;
mngr.totalSignal++;
//Debug.Log("Signal! Biotick: " + mngr.biotick + " Sum of signal: " + mngr.totalSignal);
// Report signal to cell output values
/*recA.cell.outputValues.reportSignal(recA.receptorId, recA.recPosition - recA.cell.transform.position);
* recB.cell.outputValues.reportSignal(recB.receptorId, recB.recPosition - recB.cell.transform.position);*/
//recA.cell.outputValues.aggregateBiotickSignal();
//recB.cell.outputValues.aggregateBiotickSignal();
if (bothRecsVisible())
{
lineObject.SetColors(Color.red, Color.red);
}
/* particleA.Emit(1);
* particleB.Emit(1);*/
// TRIGGER LOG?
}
//void signal (simulationManager2 mngr) {
// signalReleased = true;
// mngr.totalSignal++;
// //Debug.Log("Signal! Biotick: " + mngr.biotick + " Sum of signal: " + mngr.totalSignal);
// // Report signal to cell output values
// /*recA.cell.outputValues.reportSignal(recA.receptorId, recA.recPosition - recA.cell.transform.position);
// recB.cell.outputValues.reportSignal(recB.receptorId, recB.recPosition - recB.cell.transform.position);*/
// //recA.cell.outputValues.aggregateBiotickSignal();
// //recB.cell.outputValues.aggregateBiotickSignal();
// if (bothRecsVisible())
// lineObject.SetColors(Color.red, Color.red);
// /* particleA.Emit(1);
// particleB.Emit(1);*/
// // TRIGGER LOG?
//}
// returns true if we should remove the pair from the list of bound receptors, false otherwise.
//public bool runReceptorsForBiotick (simulationManager2 mngr, System.Random rand) {
// //Debug.DrawLine(recA.recPosition, recB.recPosition, Color.blue);
// // Should they unbind
// if (signalReleased) {
// if (rand.NextDouble () <= mngr.unbindingProbabilityAfterSignal) {
// unbind ();
// // Both receptors should endocytose (be removed from the array) after unbinding (if they released a signal)
// endocytoseReceptors();
// return true;
// }
// } else {
// if (rand.NextDouble () <= mngr.unbindingProbability) {
// unbind ();
// return true;
// }
// }
// // Should they release signal?
// if (rand.NextDouble () <= mngr.signalGenerationProbability) {
// signal (mngr);
// incBindingTime();
// return false;
// }
// incBindingTime ();
// return false;
//}
// SAME FUNCTION FOR USE WITH SimulationManager3
// returns true if we should remove the pair from the list of bound receptors, false otherwise.
public bool runReceptorsForBiotick(simulationManager3 mngr, System.Random rand)
{
//Debug.DrawLine(recA.recPosition, recB.recPosition, Color.blue);
// Should they unbind
if (signalReleased)
{
if (rand.NextDouble() <= mngr.unbindingProbabilityAfterSignal)
{
unbind();
// Both receptors should endocytose (be removed from the array) after unbinding (if they released a signal)
endocytoseReceptors();
return(true);
}
}
else
{
if (rand.NextDouble() <= mngr.unbindingProbability)
{
unbind();
return(true);
}
}
// Should they release signal?
if (rand.NextDouble() <= mngr.signalGenerationProbability)
{
signal(mngr);
incBindingTime();
return(false);
}
incBindingTime();
return(false);
}
Vector3 hardCodedCellCenter = new Vector3(-51.17f, 21.22f, 7.54f); // :_( It's the only way to find the cell body (without the filopodia) center.
// Constructor
public Receptor3(Cell2 icell, /*simulationManager2*/ simulationManager3 ismngr, System.Random rand, bool ivisible) //GameObject receptorMesh,
// saving the cell and the sim manager objets
{
cell = icell;
smngr = ismngr;
receptorId = smngr.generateUniqueId();
// Initializing variables.
nextV = -1;
totalMinisteps = 0;
currentMiniStep = 0;
// Assign position if set to random
//if (icell.randomStartingPosition) {
currentV = rand.Next(0, cell.globalMeshVerts.Length);
// COMMENTING OUT TO AVOID RUNNING THIS. PROBABLY NOT RELEVANT ANYWAY.
/*if (icell.exocytoseOutsideInteractionRadius) { // we have to check if the random position is outside the interactions radius
* while (isVertexInInteractionRadius(currentV)) { // run until you find a vertex that's outside the interaction radius
* currentV = rand.Next(0, cell.globalMeshVerts.Length);
* }
* }*/
/*if (icell.noExocytosisInFilopodia) { // we have to check if the random position is on the main body
* while (!isVertexInMainBody(currentV)) { // run until you find a vertex that's on the main body itself (not on filopodia)
* currentV = rand.Next(0, cell.globalMeshVerts.Length);
* }
* }*/
if (icell.exocytosisMainlyInFilopodia) // we have to check if the random position is on the filopodia
{
float chanceOfExocytosingInFilopodia = (float)rand.NextDouble();
if (chanceOfExocytosingInFilopodia <= icell.ratioOfExocytosingReceptorsInFilopodia)
{
// exocytose in filopodia
while (isVertexInMainBody(currentV)) // run until you find a vertex that's on the filopodia itself (not on the cell body)
{
currentV = rand.Next(0, cell.globalMeshVerts.Length);
}
}
else
{
// exocytose in cell body
while (!isVertexInMainBody(currentV)) // run until you find a vertex that's on the cell body.
{
currentV = rand.Next(0, cell.globalMeshVerts.Length);
}
}
}
recPosition = cell.globalMeshVerts[currentV];
// Create receptor mesh if visible
if (ivisible)
{
visible = true;
}
}
